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Protein

Transaldolase

Gene

TALDO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase, Transaldolase (TALDO1), Transaldolase (TALDO1)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei142Schiff-base intermediate with substrate1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pentose shunt

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciZFISH:HS11132-MONOMER.
ReactomeiR-HSA-163754. Insulin effects increased synthesis of Xylulose-5-Phosphate.
R-HSA-71336. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Gene namesi
Name:TALDO1
Synonyms:TAL, TALDO, TALDOR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11559. TALDO1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Transaldolase deficiency (TALDOD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn inborn error of the pentose phosphate pathway resulting in early-onset multisystem disease. Clinical features include growth retardation, dysmorphic features, cutis laxa, congenital heart disease, hepatosplenomegaly, telangiectases of the skin, pancytopenia, and bleeding tendency.
See also OMIM:606003
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011511171Missing in TALDOD. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6888.
MalaCardsiTALDO1.
MIMi606003. phenotype.
OpenTargetsiENSG00000177156.
Orphaneti101028. Transaldolase deficiency.
PharmGKBiPA36328.

Protein family/group databases

Allergomei9551. Hom s Transaldolase.

Polymorphism and mutation databases

BioMutaiTALDO1.
DMDMi6648092.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735641 – 337TransaldolaseAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115N6-acetyllysineBy similarity1
Modified residuei219N6-acetyllysineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Modified residuei269N6-acetyllysineCombined sources1
Modified residuei286N6-acetyllysineCombined sources1
Modified residuei321N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP37837.
MaxQBiP37837.
PaxDbiP37837.
PeptideAtlasiP37837.
PRIDEiP37837.
TopDownProteomicsiP37837.

2D gel databases

OGPiP37837.
REPRODUCTION-2DPAGEIPI00744692.

PTM databases

iPTMnetiP37837.
PhosphoSitePlusiP37837.
SwissPalmiP37837.

Expressioni

Gene expression databases

BgeeiENSG00000177156.
CleanExiHS_TALDO1.
ExpressionAtlasiP37837. baseline and differential.
GenevisibleiP37837. HS.

Organism-specific databases

HPAiHPA040373.
HPA048089.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-1056712,EBI-750109

Protein-protein interaction databases

BioGridi112751. 74 interactors.
IntActiP37837. 10 interactors.
MINTiMINT-4999914.
STRINGi9606.ENSP00000321259.

Structurei

Secondary structure

1337
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 21Combined sources8
Beta strandi22 – 27Combined sources6
Turni31 – 34Combined sources4
Helixi35 – 37Combined sources3
Beta strandi40 – 43Combined sources4
Helixi46 – 53Combined sources8
Helixi56 – 58Combined sources3
Helixi59 – 72Combined sources14
Helixi76 – 98Combined sources23
Beta strandi103 – 106Combined sources4
Helixi109 – 111Combined sources3
Helixi115 – 131Combined sources17
Helixi136 – 138Combined sources3
Beta strandi139 – 144Combined sources6
Helixi147 – 160Combined sources14
Beta strandi164 – 169Combined sources6
Helixi172 – 180Combined sources9
Beta strandi184 – 190Combined sources7
Helixi191 – 200Combined sources10
Helixi208 – 210Combined sources3
Helixi212 – 226Combined sources15
Beta strandi232 – 236Combined sources5
Helixi241 – 245Combined sources5
Turni246 – 249Combined sources4
Beta strandi250 – 255Combined sources6
Helixi257 – 265Combined sources9
Helixi276 – 281Combined sources6
Helixi291 – 299Combined sources9
Helixi302 – 330Combined sources29

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F05X-ray2.45A/B1-337[»]
ProteinModelPortaliP37837.
SMRiP37837.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37837.

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2772. Eukaryota.
COG0176. LUCA.
GeneTreeiENSGT00390000017361.
HOGENOMiHOG000281234.
HOVERGENiHBG054014.
InParanoidiP37837.
KOiK00616.
OMAiMLNEDQM.
OrthoDBiEOG091G0FTU.
PhylomeDBiP37837.
TreeFamiTF300757.

Family and domain databases

CDDicd00957. Transaldolase_TalAB. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. TAL_FSA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSPVKRQR MESALDQLKQ FTTVVADTGD FHAIDEYKPQ DATTNPSLIL
60 70 80 90 100
AAAQMPAYQE LVEEAIAYGR KLGGSQEDQI KNAIDKLFVL FGAEILKKIP
110 120 130 140 150
GRVSTEVDAR LSFDKDAMVA RARRLIELYK EAGISKDRIL IKLSSTWEGI
160 170 180 190 200
QAGKELEEQH GIHCNMTLLF SFAQAVACAE AGVTLISPFV GRILDWHVAN
210 220 230 240 250
TDKKSYEPLE DPGVKSVTKI YNYYKKFSYK TIVMGASFRN TGEIKALAGC
260 270 280 290 300
DFLTISPKLL GELLQDNAKL VPVLSAKAAQ ASDLEKIHLD EKSFRWLHNE
310 320 330
DQMAVEKLSD GIRKFAADAV KLERMLTERM FNAENGK
Length:337
Mass (Da):37,540
Last modified:May 30, 2000 - v2
Checksum:i8CB4992AEF364E64
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011511171Missing in TALDOD. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19437 mRNA. Translation: AAB53943.1.
AF010400, AF010398, AF010399 Genomic DNA. Translation: AAC52068.1.
AF058913 Genomic DNA. Translation: AAF40478.1.
AK313427 mRNA. Translation: BAG36219.1.
BC010103 mRNA. Translation: AAH10103.1.
BC018847 mRNA. Translation: AAH18847.2.
L27346 Genomic DNA. Translation: AAL31313.1.
CCDSiCCDS7712.1.
PIRiA49985.
RefSeqiNP_006746.1. NM_006755.1.
UniGeneiHs.438678.

Genome annotation databases

EnsembliENST00000319006; ENSP00000321259; ENSG00000177156.
GeneIDi6888.
KEGGihsa:6888.
UCSCiuc001lqz.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19437 mRNA. Translation: AAB53943.1.
AF010400, AF010398, AF010399 Genomic DNA. Translation: AAC52068.1.
AF058913 Genomic DNA. Translation: AAF40478.1.
AK313427 mRNA. Translation: BAG36219.1.
BC010103 mRNA. Translation: AAH10103.1.
BC018847 mRNA. Translation: AAH18847.2.
L27346 Genomic DNA. Translation: AAL31313.1.
CCDSiCCDS7712.1.
PIRiA49985.
RefSeqiNP_006746.1. NM_006755.1.
UniGeneiHs.438678.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F05X-ray2.45A/B1-337[»]
ProteinModelPortaliP37837.
SMRiP37837.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112751. 74 interactors.
IntActiP37837. 10 interactors.
MINTiMINT-4999914.
STRINGi9606.ENSP00000321259.

Protein family/group databases

Allergomei9551. Hom s Transaldolase.

PTM databases

iPTMnetiP37837.
PhosphoSitePlusiP37837.
SwissPalmiP37837.

Polymorphism and mutation databases

BioMutaiTALDO1.
DMDMi6648092.

2D gel databases

OGPiP37837.
REPRODUCTION-2DPAGEIPI00744692.

Proteomic databases

EPDiP37837.
MaxQBiP37837.
PaxDbiP37837.
PeptideAtlasiP37837.
PRIDEiP37837.
TopDownProteomicsiP37837.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319006; ENSP00000321259; ENSG00000177156.
GeneIDi6888.
KEGGihsa:6888.
UCSCiuc001lqz.4. human.

Organism-specific databases

CTDi6888.
DisGeNETi6888.
GeneCardsiTALDO1.
HGNCiHGNC:11559. TALDO1.
HPAiHPA040373.
HPA048089.
MalaCardsiTALDO1.
MIMi602063. gene.
606003. phenotype.
neXtProtiNX_P37837.
OpenTargetsiENSG00000177156.
Orphaneti101028. Transaldolase deficiency.
PharmGKBiPA36328.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2772. Eukaryota.
COG0176. LUCA.
GeneTreeiENSGT00390000017361.
HOGENOMiHOG000281234.
HOVERGENiHBG054014.
InParanoidiP37837.
KOiK00616.
OMAiMLNEDQM.
OrthoDBiEOG091G0FTU.
PhylomeDBiP37837.
TreeFamiTF300757.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.
BioCyciZFISH:HS11132-MONOMER.
ReactomeiR-HSA-163754. Insulin effects increased synthesis of Xylulose-5-Phosphate.
R-HSA-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

ChiTaRSiTALDO1. human.
EvolutionaryTraceiP37837.
GenomeRNAii6888.
PROiP37837.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177156.
CleanExiHS_TALDO1.
ExpressionAtlasiP37837. baseline and differential.
GenevisibleiP37837. HS.

Family and domain databases

CDDicd00957. Transaldolase_TalAB. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. TAL_FSA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTALDO_HUMAN
AccessioniPrimary (citable) accession number: P37837
Secondary accession number(s): B2R8M2
, O00751, Q8WV32, Q8WZ45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 184 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.