Reviewed, UniProtKB/Swiss-Prot P37831 (LOX1_SOLTU)

Names and origin

Protein names

Recommended name:
    Lipoxygenase 1
    EC=1.13.11.12

Gene names

Name:	LOX1.1
Synonyms:	LOX1

Organism

Solanum tuberosum (Potato)

Taxonomic identifier

4113 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum

Protein attributes

Sequence length	861 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. It catalyzes the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure.
Catalytic activity	Linoleate + O(2) = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate.
Cofactor	Binds 1 iron ion per subunit. Iron is tightly bound By similarity.
Pathway	Lipid metabolism; oxylipin biosynthesis.
Subunit structure	Monomer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the lipoxygenase family. Contains 1 lipoxygenase domain. Contains 1 PLAT domain.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis Oxylipin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW oxylipin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro lipoxygenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 861	861	Lipoxygenase 1		PRO_0000220722
Regions
	Domain	29 – 160	132	PLAT
	Domain	163 – 861	699	Lipoxygenase
Sites
	Metal binding	522	1	Iron; catalytic By similarity
	Metal binding	527	1	Iron; catalytic By similarity
	Metal binding	713	1	Iron; catalytic By similarity
	Metal binding	717	1	Iron; catalytic By similarity
	Metal binding	861	1	Iron; via carboxylate; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P37831-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 09732A6751DEE20D	FASTA	861	96,967
	10 20 30 40 50 60 MIGQITSGLF GGHDDSKKVK GTVVMMNKNV LDFTDLAGSL TGKIFDVLGQ KVSFQLISSV 70 80 90 100 110 120 QGDPTNGLQG KHSNPAYLEN SLFTLTPLTA GSETAFGVTF DWNEEFGVPG AFIIKNMHIN 130 140 150 160 170 180 EFFLKSLTLE DVPNHGKVHF VCNSWVYPSL NYKSDRIFFA NQPYLPSETP ELLRKYRENE 190 200 210 220 230 240 LLTLRGDGTG KREAWDRIYD YDIYNDLGNP DQGKENVRTT LGGSAEYPYP RRGRTGRPPT 250 260 270 280 290 300 RTDPKSESRI PLILSLDIYV PRDERFGHLK MSDFLTYALK SIVQFILPEL HALFDGTPNE 310 320 330 340 350 360 FDSFEDVLRL YEGGIKLPQG PLFKALTAAI PLEMIRELLR TDGEGILRFP TPLVIKDSKT 370 380 390 400 410 420 AWRTDEEFAR EMLAGVNPVI ISRLQEFPPK SKLDPEAYGN QNSTITAEHI EDKLDGLTVD 430 440 450 460 470 480 EAMNNNKLFI LNHHDVIIPY LRRINTTITK AYASRTLLFL QDNGSLKPLA IELSFPHPDG 490 500 510 520 530 540 DQFGVTSKVY TPSDQGVESS IWQLAKAYVA VNDVGVHQLI SHWLNTHAVI EPFVIATNRQ 550 560 570 580 590 600 LSVLHPIHKL LYPHFRDTMN INASARQLLV NAGGVLESTV FQSKFAMEMS AVVYKDWVFP 610 620 630 640 650 660 DQALPADLVK RGVAVEDSSS PHGVRLLIED YPYAVDGLEI WSAIKSWVTD YCSFYYGSDE 670 680 690 700 710 720 EILKDNELQA WWKELREVGH GDKKNEPWWP EMETPQELID SCTTIIWIAS ALHAAVNFGQ 730 740 750 760 770 780 YPYAGYLPNR PTVSRRFMPE PGTPEYEELK RNPDKAFLKT ITAQLQTLLG VSLVEILSRH 790 800 810 820 830 840 TTDEIYLGQR ESPEWTKDKE PLAAFDRFGK KLTDIEKQII QRNGDNILTN RSGPVNAPYT 850 860 LLFPTSEGGL TGKGIPNSVS I

References

[1]	"Sequence of a cDNA clone encoding a potato (Solanum tuberosum) tuber lipoxygenase." Casey R. Plant Physiol. 107:265-266(1995) [PubMed: 7870815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Desiree. Tissue: Tuber.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X79107 mRNA. Translation: CAA55724.1.
PIR	S44940.
3D structure databases
HSSP	HSSP built from PDB template 1FGT based on UniProtKB P08170.
ModBase	Search...
Family and domain databases
InterPro	IPR000907. LipOase. IPR013819. LipOase_C. IPR001024. LipOase_LH2. IPR001246. LipOase_pln. [Graphical view]
Gene3D	G3DSA:2.60.60.20. Lipase_LipOase. 1 hit.
PANTHER	PTHR11771. LipOase. 1 hit.
Pfam	PF00305. Lipoxygenase. 1 hit. PF01477. PLAT. 1 hit. [Graphical view]
PRINTS	PR00087. LIPOXYGENASE. PR00468. PLTLPOXGNASE.
SMART	SM00308. LH2. 1 hit. [Graphical view]
PROSITE	PS00711. LIPOXYGENASE_1. 1 hit. PS00081. LIPOXYGENASE_2. 1 hit. PS51393. LIPOXYGENASE_3. 1 hit. PS50095. PLAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LOX1_SOLTU

Accession

Primary (citable) accession number: P37831

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	November 25, 2008
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)