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P37830

- G6PD_SOLTU

UniProt

P37830 - G6PD_SOLTU

Protein

Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform

Gene

G6PDH

Organism
Solanum tuberosum (Potato)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to generate NADPH for reductive biosyntheses.

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Enzyme regulationi

    Regulated by metabolites.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei71 – 711NADPBy similarity
    Binding sitei178 – 1781NADP; via carbonyl oxygenBy similarity
    Binding sitei178 – 1781SubstrateBy similarity
    Binding sitei246 – 2461SubstrateBy similarity
    Binding sitei265 – 2651SubstrateBy similarity
    Active sitei270 – 2701Proton acceptorBy similarity
    Binding sitei356 – 3561SubstrateBy similarity
    Binding sitei361 – 3611SubstrateBy similarity
    Binding sitei392 – 3921SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi36 – 438NADPBy similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pentose-phosphate shunt, oxidative branch Source: EnsemblPlants/Gramene
    2. response to cadmium ion Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    SABIO-RKP37830.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform (EC:1.1.1.49)
    Short name:
    G6PD
    Gene namesi
    Name:G6PDH
    OrganismiSolanum tuberosum (Potato)
    Taxonomic identifieri4113 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
    ProteomesiUP000011115: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoformPRO_0000068101Add
    BLAST

    Proteomic databases

    PRIDEiP37830.

    Expressioni

    Tissue specificityi

    Found in tubers, stolons, roots, and flower buds.

    Interactioni

    Subunit structurei

    Homotetramer.

    Structurei

    3D structure databases

    ProteinModelPortaliP37830.
    SMRiP37830. Positions 31-507.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni208 – 2125Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37830-1 [UniParc]FASTAAdd to Basket

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    MAASWCIEKR GSIRNDSFRD NDNIPETGCL SIIVLGASGD LAKKKTFPAL    50
    FNLYRQGFLQ SNEVHIFGYA RTKISDDDLR SRIRGYLSQG KENEGEVSEF 100
    LQLIKYVSGS YDSAEGFTSL DKAISEHEFS KNSTEGSSRR LFYFALPPSV 150
    YPSVCRMIKS YCMNKSDLGG WTRTVVEKPF GKDLASSEQL SSQIGELFDE 200
    PQIYRIDHYL GKELVQNLLV LRFANRFFLP LWNRDNIDNI QIVFREDFGT 250
    EGRGGYFDEY GIIRDIIQNH LLQVLCLVAM EKPVSQKPEH IRDEKVKVLQ 300
    SMLPIEDEEV VLGQYEGYKD DPTVPNNSNT PTFATMVLRI HNERWEGVPF 350
    IMKAGKALNS RKAEIRVQFK DVPGDIFRCQ KQGRNEFVIR LQPSEAMYMK 400
    LTVKKPGLEM STVQSELDLS YGQRYQGVVI PEAYERLILD TIRGDQQHFV 450
    RRDELKAAWE IFTPLLHRID NGEVKPIPYK PGSRGPAEAD ELLQNAGYVQ 500
    THGYIWIPPT L 511
    Length:511
    Mass (Da):58,471
    Last modified:October 1, 1994 - v1
    Checksum:iBBD9E4891DA62671
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74421 mRNA. Translation: CAA52442.1.
    PIRiS60287.
    UniGeneiStu.18101.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74421 mRNA. Translation: CAA52442.1 .
    PIRi S60287.
    UniGenei Stu.18101.

    3D structure databases

    ProteinModelPortali P37830.
    SMRi P37830. Positions 31-507.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P37830.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    SABIO-RK P37830.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification, characterization, and cDNA sequence of glucose-6-phosphate dehydrogenase from potato (Solanum tuberosum L.)."
      Graeve K., von Schaewen A., Scheibe R.
      Plant J. 5:353-361(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Desiree.
      Tissue: Green leaf.

    Entry informationi

    Entry nameiG6PD_SOLTU
    AccessioniPrimary (citable) accession number: P37830
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3