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P37830

- G6PD_SOLTU

UniProt

P37830 - G6PD_SOLTU

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Protein

Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform

Gene

G6PDH

Organism
Solanum tuberosum (Potato)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to generate NADPH for reductive biosyntheses.

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Enzyme regulationi

Regulated by metabolites.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei71 – 711NADPBy similarity
Binding sitei178 – 1781NADP; via carbonyl oxygenBy similarity
Binding sitei178 – 1781SubstrateBy similarity
Binding sitei246 – 2461SubstrateBy similarity
Binding sitei265 – 2651SubstrateBy similarity
Active sitei270 – 2701Proton acceptorBy similarity
Binding sitei356 – 3561SubstrateBy similarity
Binding sitei361 – 3611SubstrateBy similarity
Binding sitei392 – 3921SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 438NADPBy similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

SABIO-RKP37830.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:G6PDH
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
ProteomesiUP000011115: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoformPRO_0000068101Add
BLAST

Proteomic databases

PRIDEiP37830.

Expressioni

Tissue specificityi

Found in tubers, stolons, roots, and flower buds.

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliP37830.
SMRiP37830. Positions 31-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni208 – 2125Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

InParanoidiP37830.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37830-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASWCIEKR GSIRNDSFRD NDNIPETGCL SIIVLGASGD LAKKKTFPAL
60 70 80 90 100
FNLYRQGFLQ SNEVHIFGYA RTKISDDDLR SRIRGYLSQG KENEGEVSEF
110 120 130 140 150
LQLIKYVSGS YDSAEGFTSL DKAISEHEFS KNSTEGSSRR LFYFALPPSV
160 170 180 190 200
YPSVCRMIKS YCMNKSDLGG WTRTVVEKPF GKDLASSEQL SSQIGELFDE
210 220 230 240 250
PQIYRIDHYL GKELVQNLLV LRFANRFFLP LWNRDNIDNI QIVFREDFGT
260 270 280 290 300
EGRGGYFDEY GIIRDIIQNH LLQVLCLVAM EKPVSQKPEH IRDEKVKVLQ
310 320 330 340 350
SMLPIEDEEV VLGQYEGYKD DPTVPNNSNT PTFATMVLRI HNERWEGVPF
360 370 380 390 400
IMKAGKALNS RKAEIRVQFK DVPGDIFRCQ KQGRNEFVIR LQPSEAMYMK
410 420 430 440 450
LTVKKPGLEM STVQSELDLS YGQRYQGVVI PEAYERLILD TIRGDQQHFV
460 470 480 490 500
RRDELKAAWE IFTPLLHRID NGEVKPIPYK PGSRGPAEAD ELLQNAGYVQ
510
THGYIWIPPT L
Length:511
Mass (Da):58,471
Last modified:October 1, 1994 - v1
Checksum:iBBD9E4891DA62671
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74421 mRNA. Translation: CAA52442.1.
PIRiS60287.
UniGeneiStu.18101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74421 mRNA. Translation: CAA52442.1 .
PIRi S60287.
UniGenei Stu.18101.

3D structure databases

ProteinModelPortali P37830.
SMRi P37830. Positions 31-507.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P37830.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

InParanoidi P37830.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
SABIO-RK P37830.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification, characterization, and cDNA sequence of glucose-6-phosphate dehydrogenase from potato (Solanum tuberosum L.)."
    Graeve K., von Schaewen A., Scheibe R.
    Plant J. 5:353-361(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Desiree.
    Tissue: Green leaf.

Entry informationi

Entry nameiG6PD_SOLTU
AccessioniPrimary (citable) accession number: P37830
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3