Reviewed,
UniProtKB/Swiss-Prot P37830 (G6PD_SOLTU)
Last modified
November 25, 2008.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform Short name=G6PD EC=1.1.1.49 | ||
| Gene names |
| ||
| Organism | Solanum tuberosum (Potato) | ||
| Taxonomic identifier | 4113 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum |
Protein attributes
| Sequence length | 511 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to generate NADPH for reductive biosyntheses. |
| Catalytic activity | D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH. |
| Enzyme regulation | Regulated by metabolites. |
| Pathway | |
| Subunit structure | Homotetramer. |
| Subcellular location | |
| Tissue specificity | Found in tubers, stolons, roots, and flower buds. |
| Sequence similarities | Belongs to the glucose-6-phosphate dehydrogenase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism Glucose metabolism |
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
Gene Ontology (GO) | |
| Biological process | glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 511 | 511 | Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform | PRO_0000068101 | |||||
Sites | |||||||||
| Active site | 270 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 38 | 1 | NADP By similarity | ||||||
| Binding site | 71 | 1 | NADP By similarity | ||||||
| Binding site | 208 | 1 | Substrate By similarity | ||||||
| Binding site | 212 | 1 | Substrate By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Purification, characterization, and cDNA sequence of glucose-6-phosphate dehydrogenase from potato (Solanum tuberosum L.)." Graeve K., von Schaewen A., Scheibe R. Plant J. 5:353-361(1994) [PubMed: 8180621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Desiree. Tissue: Green leaf. |
Cross-references
Sequence databases | |
|---|---|
| X74421 mRNA. Translation: CAA52442.1. | |
| PIR | S60287. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1QKI based on UniProtKB P11413. |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR23429. G6PDH. 1 hit. |
| Pfam | PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000110. G6PD. 1 hit. |
| PRINTS | PR00079. G6PDHDRGNASE. |
| ProDom | PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00871. zwf. 1 hit. |
| PROSITE | PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | G6PD_SOLTU | ||||||||
| Accession | Primary (citable) accession number: P37830 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


