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P37830

- G6PD_SOLTU

UniProt

P37830 - G6PD_SOLTU

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Protein

Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform

Gene
G6PDH
Organism
Solanum tuberosum (Potato)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to generate NADPH for reductive biosyntheses.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Enzyme regulationi

Regulated by metabolites.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei71 – 711NADP By similarity
Binding sitei178 – 1781NADP; via carbonyl oxygen By similarity
Binding sitei178 – 1781Substrate By similarity
Binding sitei246 – 2461Substrate By similarity
Binding sitei265 – 2651Substrate By similarity
Active sitei270 – 2701Proton acceptor By similarity
Binding sitei356 – 3561Substrate By similarity
Binding sitei361 – 3611Substrate By similarity
Binding sitei392 – 3921Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 438NADP By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pentose-phosphate shunt, oxidative branch Source: EnsemblPlants/Gramene
  2. response to cadmium ion Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

SABIO-RKP37830.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:G6PDH
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
ProteomesiUP000011115: Unplaced

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. chloroplast Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoformUniRule annotationPRO_0000068101Add
BLAST

Proteomic databases

PRIDEiP37830.

Expressioni

Tissue specificityi

Found in tubers, stolons, roots, and flower buds.

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliP37830.
SMRiP37830. Positions 31-507.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni208 – 2125Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37830-1 [UniParc]FASTAAdd to Basket

« Hide

MAASWCIEKR GSIRNDSFRD NDNIPETGCL SIIVLGASGD LAKKKTFPAL    50
FNLYRQGFLQ SNEVHIFGYA RTKISDDDLR SRIRGYLSQG KENEGEVSEF 100
LQLIKYVSGS YDSAEGFTSL DKAISEHEFS KNSTEGSSRR LFYFALPPSV 150
YPSVCRMIKS YCMNKSDLGG WTRTVVEKPF GKDLASSEQL SSQIGELFDE 200
PQIYRIDHYL GKELVQNLLV LRFANRFFLP LWNRDNIDNI QIVFREDFGT 250
EGRGGYFDEY GIIRDIIQNH LLQVLCLVAM EKPVSQKPEH IRDEKVKVLQ 300
SMLPIEDEEV VLGQYEGYKD DPTVPNNSNT PTFATMVLRI HNERWEGVPF 350
IMKAGKALNS RKAEIRVQFK DVPGDIFRCQ KQGRNEFVIR LQPSEAMYMK 400
LTVKKPGLEM STVQSELDLS YGQRYQGVVI PEAYERLILD TIRGDQQHFV 450
RRDELKAAWE IFTPLLHRID NGEVKPIPYK PGSRGPAEAD ELLQNAGYVQ 500
THGYIWIPPT L 511
Length:511
Mass (Da):58,471
Last modified:October 1, 1994 - v1
Checksum:iBBD9E4891DA62671
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74421 mRNA. Translation: CAA52442.1.
PIRiS60287.
UniGeneiStu.18101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74421 mRNA. Translation: CAA52442.1 .
PIRi S60287.
UniGenei Stu.18101.

3D structure databases

ProteinModelPortali P37830.
SMRi P37830. Positions 31-507.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P37830.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
SABIO-RK P37830.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification, characterization, and cDNA sequence of glucose-6-phosphate dehydrogenase from potato (Solanum tuberosum L.)."
    Graeve K., von Schaewen A., Scheibe R.
    Plant J. 5:353-361(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Desiree.
    Tissue: Green leaf.

Entry informationi

Entry nameiG6PD_SOLTU
AccessioniPrimary (citable) accession number: P37830
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 19, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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