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Protein

Transgelin

Gene

Tagln

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Actin cross-linking/gelling protein.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin
Alternative name(s):
Actin-associated protein p27
Smooth muscle protein 22-alpha
Short name:
SM22-alpha
Gene namesi
Name:Tagln
Synonyms:Sm22, Sm22a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:106012. Tagln.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002047822 – 201TransgelinAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineSequence analysisBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei172N6-acetyllysineCombined sources1
Modified residuei181PhosphoserineBy similarity1
Modified residuei183Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiP37804.
PaxDbiP37804.
PeptideAtlasiP37804.
PRIDEiP37804.

2D gel databases

REPRODUCTION-2DPAGEIPI00226515.

PTM databases

iPTMnetiP37804.
PhosphoSitePlusiP37804.
SwissPalmiP37804.

Expressioni

Inductioni

By growth factors.

Gene expression databases

BgeeiENSMUSG00000032085.
CleanExiMM_TAGLN.
GenevisibleiP37804. MM.

Interactioni

Protein-protein interaction databases

BioGridi203960. 1 interactor.
IntActiP37804. 3 interactors.
MINTiMINT-4136841.
STRINGi10090.ENSMUSP00000034590.

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 38Combined sources14
Beta strandi47 – 51Combined sources5
Helixi52 – 55Combined sources4
Helixi60 – 69Combined sources10
Turni72 – 74Combined sources3
Helixi87 – 104Combined sources18
Beta strandi108 – 110Combined sources3
Helixi114 – 118Combined sources5
Helixi123 – 140Combined sources18
Turni150 – 152Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UJONMR-A24-154[»]
ProteinModelPortaliP37804.
SMRiP37804.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37804.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 137CHPROSITE-ProRule annotationAdd BLAST114
Repeati175 – 200Calponin-likeAdd BLAST26

Sequence similaritiesi

Belongs to the calponin family.Curated
Contains 1 calponin-like repeat.PROSITE-ProRule annotation
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiP37804.
KOiK20526.
OMAiVEWIVVQ.
OrthoDBiEOG091G0LY2.
PhylomeDBiP37804.
TreeFamiTF313921.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIVVQCGP DVGRPDRGRL
60 70 80 90 100
GFQVWLKNGV ILSKLVNSLY PEGSKPVKVP ENPPSMVFKQ MEQVAQFLKA
110 120 130 140 150
AEDYGVIKTD MFQTVDLYEG KDMAAVQRTL MALGSLAVTK NDGNYRGDPN
160 170 180 190 200
WFMKKAQEHK RDFTDSQLQE GKHVIGLQMG SNRGASQAGM TGYGRPRQII

S
Length:201
Mass (Da):22,576
Last modified:January 23, 2007 - v3
Checksum:i465F732D706F760A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44R → A no nucleotide entry (PubMed:2924801).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41170, L41169 Genomic DNA. Translation: AAA79165.1.
L41154 mRNA. Translation: AAA79166.1.
Z68618 Genomic DNA. Translation: CAA92941.1.
U36588 mRNA. Translation: AAC52418.1.
AK002880 mRNA. Translation: BAB22427.1.
AK077235 mRNA. Translation: BAC36700.1.
BC003795 mRNA. Translation: AAH03795.1.
CCDSiCCDS23137.1.
PIRiA57015.
A60598.
RefSeqiNP_035656.1. NM_011526.5.
UniGeneiMm.283283.

Genome annotation databases

EnsembliENSMUST00000034590; ENSMUSP00000034590; ENSMUSG00000032085.
GeneIDi21345.
KEGGimmu:21345.
UCSCiuc009pgs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41170, L41169 Genomic DNA. Translation: AAA79165.1.
L41154 mRNA. Translation: AAA79166.1.
Z68618 Genomic DNA. Translation: CAA92941.1.
U36588 mRNA. Translation: AAC52418.1.
AK002880 mRNA. Translation: BAB22427.1.
AK077235 mRNA. Translation: BAC36700.1.
BC003795 mRNA. Translation: AAH03795.1.
CCDSiCCDS23137.1.
PIRiA57015.
A60598.
RefSeqiNP_035656.1. NM_011526.5.
UniGeneiMm.283283.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UJONMR-A24-154[»]
ProteinModelPortaliP37804.
SMRiP37804.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203960. 1 interactor.
IntActiP37804. 3 interactors.
MINTiMINT-4136841.
STRINGi10090.ENSMUSP00000034590.

PTM databases

iPTMnetiP37804.
PhosphoSitePlusiP37804.
SwissPalmiP37804.

2D gel databases

REPRODUCTION-2DPAGEIPI00226515.

Proteomic databases

MaxQBiP37804.
PaxDbiP37804.
PeptideAtlasiP37804.
PRIDEiP37804.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034590; ENSMUSP00000034590; ENSMUSG00000032085.
GeneIDi21345.
KEGGimmu:21345.
UCSCiuc009pgs.2. mouse.

Organism-specific databases

CTDi6876.
MGIiMGI:106012. Tagln.

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiP37804.
KOiK20526.
OMAiVEWIVVQ.
OrthoDBiEOG091G0LY2.
PhylomeDBiP37804.
TreeFamiTF313921.

Miscellaneous databases

EvolutionaryTraceiP37804.
PROiP37804.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032085.
CleanExiMM_TAGLN.
GenevisibleiP37804. MM.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAGL_MOUSE
AccessioniPrimary (citable) accession number: P37804
Secondary accession number(s): Q545W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.