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Protein

Transgelin

Gene

Tagln

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Actin cross-linking/gelling protein.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin
Alternative name(s):
Actin-associated protein p27
Smooth muscle protein 22-alpha
Short name:
SM22-alpha
Gene namesi
Name:Tagln
Synonyms:Sm22, Sm22a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:106012. Tagln.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 201200TransgelinPRO_0000204782Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineSequence analysisBy similarity
Modified residuei166 – 1661PhosphoserineBy similarity
Modified residuei172 – 1721N6-acetyllysineCombined sources
Modified residuei181 – 1811PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP37804.
MaxQBiP37804.
PaxDbiP37804.
PeptideAtlasiP37804.
PRIDEiP37804.

2D gel databases

REPRODUCTION-2DPAGEIPI00226515.

PTM databases

iPTMnetiP37804.
PhosphoSiteiP37804.
SwissPalmiP37804.

Expressioni

Inductioni

By growth factors.

Gene expression databases

BgeeiP37804.
CleanExiMM_TAGLN.
GenevisibleiP37804. MM.

Interactioni

Protein-protein interaction databases

BioGridi203960. 1 interaction.
IntActiP37804. 3 interactions.
MINTiMINT-4136841.
STRINGi10090.ENSMUSP00000034590.

Structurei

Secondary structure

1
201
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi25 – 3814Combined sources
Beta strandi47 – 515Combined sources
Helixi52 – 554Combined sources
Helixi60 – 6910Combined sources
Turni72 – 743Combined sources
Helixi87 – 10418Combined sources
Beta strandi108 – 1103Combined sources
Helixi114 – 1185Combined sources
Helixi123 – 14018Combined sources
Turni150 – 1523Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UJONMR-A24-154[»]
ProteinModelPortaliP37804.
SMRiP37804. Positions 24-154.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37804.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 137114CHPROSITE-ProRule annotationAdd
BLAST
Repeati175 – 20026Calponin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the calponin family.Curated
Contains 1 calponin-like repeat.PROSITE-ProRule annotation
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiP37804.
OMAiVEWIVVQ.
OrthoDBiEOG718KD9.
PhylomeDBiP37804.
TreeFamiTF313921.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIVVQCGP DVGRPDRGRL
60 70 80 90 100
GFQVWLKNGV ILSKLVNSLY PEGSKPVKVP ENPPSMVFKQ MEQVAQFLKA
110 120 130 140 150
AEDYGVIKTD MFQTVDLYEG KDMAAVQRTL MALGSLAVTK NDGNYRGDPN
160 170 180 190 200
WFMKKAQEHK RDFTDSQLQE GKHVIGLQMG SNRGASQAGM TGYGRPRQII

S
Length:201
Mass (Da):22,576
Last modified:January 23, 2007 - v3
Checksum:i465F732D706F760A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441R → A no nucleotide entry (PubMed:2924801).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41170, L41169 Genomic DNA. Translation: AAA79165.1.
L41154 mRNA. Translation: AAA79166.1.
Z68618 Genomic DNA. Translation: CAA92941.1.
U36588 mRNA. Translation: AAC52418.1.
AK002880 mRNA. Translation: BAB22427.1.
AK077235 mRNA. Translation: BAC36700.1.
BC003795 mRNA. Translation: AAH03795.1.
CCDSiCCDS23137.1.
PIRiA57015.
A60598.
RefSeqiNP_035656.1. NM_011526.5.
UniGeneiMm.283283.

Genome annotation databases

EnsembliENSMUST00000034590; ENSMUSP00000034590; ENSMUSG00000032085.
GeneIDi21345.
KEGGimmu:21345.
UCSCiuc009pgs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41170, L41169 Genomic DNA. Translation: AAA79165.1.
L41154 mRNA. Translation: AAA79166.1.
Z68618 Genomic DNA. Translation: CAA92941.1.
U36588 mRNA. Translation: AAC52418.1.
AK002880 mRNA. Translation: BAB22427.1.
AK077235 mRNA. Translation: BAC36700.1.
BC003795 mRNA. Translation: AAH03795.1.
CCDSiCCDS23137.1.
PIRiA57015.
A60598.
RefSeqiNP_035656.1. NM_011526.5.
UniGeneiMm.283283.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UJONMR-A24-154[»]
ProteinModelPortaliP37804.
SMRiP37804. Positions 24-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203960. 1 interaction.
IntActiP37804. 3 interactions.
MINTiMINT-4136841.
STRINGi10090.ENSMUSP00000034590.

PTM databases

iPTMnetiP37804.
PhosphoSiteiP37804.
SwissPalmiP37804.

2D gel databases

REPRODUCTION-2DPAGEIPI00226515.

Proteomic databases

EPDiP37804.
MaxQBiP37804.
PaxDbiP37804.
PeptideAtlasiP37804.
PRIDEiP37804.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034590; ENSMUSP00000034590; ENSMUSG00000032085.
GeneIDi21345.
KEGGimmu:21345.
UCSCiuc009pgs.2. mouse.

Organism-specific databases

CTDi6876.
MGIiMGI:106012. Tagln.

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiP37804.
OMAiVEWIVVQ.
OrthoDBiEOG718KD9.
PhylomeDBiP37804.
TreeFamiTF313921.

Miscellaneous databases

EvolutionaryTraceiP37804.
PROiP37804.
SOURCEiSearch...

Gene expression databases

BgeeiP37804.
CleanExiMM_TAGLN.
GenevisibleiP37804. MM.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of a smooth muscle cell-specific gene, SM22 alpha."
    Solway J., Seltzer J., Samaha F.F., Kim S., Alger L.E., Niu Q., Morrisey E.E., Ip H.S., Parmacek M.S.
    J. Biol. Chem. 270:13460-13469(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv.
    Tissue: Liver.
  2. "Expression, cloning and cDNA sequence of a fibroblast serum-regulated gene encoding a putative actin-associated protein (p27)."
    Almendral J.M., Santaren J.F., Perera J., Zerial M., Bravo R.
    Exp. Cell Res. 181:518-530(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Moessler H., Mericskay M., Li Z., Nagl S., Small J.V., Paulin D.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  4. "SM22 alpha, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis."
    Li L., Miano J.M., Cserjesi P., Olson E.N.
    Circ. Res. 78:188-195(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: SWR/J.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney, Ovary and Uterus.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-172, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  9. "Solution structure of the CH domain from mouse transgelin."
    RIKEN structural genomics initiative (RSGI)
    Submitted (SEP-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 24-154.

Entry informationi

Entry nameiTAGL_MOUSE
AccessioniPrimary (citable) accession number: P37804
Secondary accession number(s): Q545W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.