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Protein

Transgelin-2

Gene

TAGLN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

GO - Biological processi

  • epithelial cell differentiation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin-2
Alternative name(s):
Epididymis tissue protein Li 7e
SM22-alpha homolog
Gene namesi
Name:TAGLN2
Synonyms:KIAA0120
ORF Names:CDABP0035
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11554. TAGLN2.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • vesicle Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi8407.
OpenTargetsiENSG00000158710.
PharmGKBiPA36325.

Polymorphism and mutation databases

DMDMi586000.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002047862 – 199Transgelin-2Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei11PhosphoserineCombined sources1
Modified residuei17N6-acetyllysineCombined sources1
Modified residuei20N6-acetyllysineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei180PhosphothreonineCombined sources1
Modified residuei182Omega-N-methylarginineCombined sources1
Modified residuei196Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP37802.
MaxQBiP37802.
PaxDbiP37802.
PeptideAtlasiP37802.
PRIDEiP37802.
TopDownProteomicsiP37802-1. [P37802-1]

2D gel databases

DOSAC-COBS-2DPAGEP37802.
OGPiP37802.
REPRODUCTION-2DPAGEP37802.

PTM databases

iPTMnetiP37802.
PhosphoSitePlusiP37802.
SwissPalmiP37802.

Expressioni

Tissue specificityi

Expressed in epididymis (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000158710.
CleanExiHS_TAGLN2.
ExpressionAtlasiP37802. baseline and differential.
GenevisibleiP37802. HS.

Organism-specific databases

HPAiHPA001925.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTBP607093EBI-1056740,EBI-353944

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi113995. 118 interactors.
IntActiP37802. 19 interactors.
MINTiMINT-5001664.
STRINGi9606.ENSP00000357075.

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 37Combined sources14
Beta strandi38 – 40Combined sources3
Helixi49 – 57Combined sources9
Helixi60 – 69Combined sources10
Turni72 – 74Combined sources3
Helixi86 – 103Combined sources18
Turni107 – 109Combined sources3
Helixi113 – 117Combined sources5
Helixi122 – 136Combined sources15
Beta strandi140 – 142Combined sources3
Beta strandi148 – 151Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WYMNMR-A16-157[»]
ProteinModelPortaliP37802.
SMRiP37802.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37802.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 136CHPROSITE-ProRule annotationAdd BLAST113
Repeati174 – 199Calponin-likeAdd BLAST26

Sequence similaritiesi

Belongs to the calponin family.Curated
Contains 1 calponin-like repeat.PROSITE-ProRule annotation
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiP37802.
KOiK20526.
OMAiFRMANRG.
OrthoDBiEOG091G0LY2.
PhylomeDBiP37802.
TreeFamiTF313921.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P37802-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANRGPAYGL SREVQQKIEK QYDADLEQIL IQWITTQCRK DVGRPQPGRE
60 70 80 90 100
NFQNWLKDGT VLCELINALY PEGQAPVKKI QASTMAFKQM EQISQFLQAA
110 120 130 140 150
ERYGINTTDI FQTVDLWEGK NMACVQRTLM NLGGLAVARD DGLFSGDPNW
160 170 180 190
FPKKSKENPR NFSDNQLQEG KNVIGLQMGT NRGASQAGMT GYGMPRQIL
Length:199
Mass (Da):22,391
Last modified:January 23, 2007 - v3
Checksum:i07DFC1652CE2383D
GO
Isoform 2 (identifier: P37802-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSAFSLALALVSSPQPPPPIGM

Note: No experimental confirmation available.
Show »
Length:220
Mass (Da):24,454
Checksum:iDD4502C038B8D6F6
GO

Sequence cautioni

The sequence BAA04802 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI14604 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04790369L → Q.1 PublicationCorresponds to variant rs17849636dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0553111M → MSAFSLALALVSSPQPPPPI GM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007127 mRNA. Translation: AAG01993.1.
D21261 mRNA. Translation: BAA04802.2. Different initiation.
GU727636 mRNA. Translation: ADU87638.1.
AK291562 mRNA. Translation: BAF84251.1.
CR542126 mRNA. Translation: CAG46923.1.
CR542136 mRNA. Translation: CAG46933.1.
AL513485 Genomic DNA. Translation: CAI14603.1.
AL513485 Genomic DNA. Translation: CAI14604.1. Different initiation.
AL513485 Genomic DNA. Translation: CAI14602.1.
CH471121 Genomic DNA. Translation: EAW52760.1.
BC002616 mRNA. Translation: AAH02616.1.
BC009357 mRNA. Translation: AAH09357.1.
CCDSiCCDS1189.1. [P37802-1]
CCDS60314.1. [P37802-2]
RefSeqiNP_001264152.1. NM_001277223.1. [P37802-1]
NP_001264153.1. NM_001277224.1. [P37802-2]
NP_003555.1. NM_003564.2. [P37802-1]
UniGeneiHs.517168.

Genome annotation databases

EnsembliENST00000320307; ENSP00000357075; ENSG00000158710. [P37802-1]
ENST00000368096; ENSP00000357076; ENSG00000158710. [P37802-2]
ENST00000368097; ENSP00000357077; ENSG00000158710. [P37802-1]
GeneIDi8407.
KEGGihsa:8407.
UCSCiuc001fun.3. human. [P37802-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007127 mRNA. Translation: AAG01993.1.
D21261 mRNA. Translation: BAA04802.2. Different initiation.
GU727636 mRNA. Translation: ADU87638.1.
AK291562 mRNA. Translation: BAF84251.1.
CR542126 mRNA. Translation: CAG46923.1.
CR542136 mRNA. Translation: CAG46933.1.
AL513485 Genomic DNA. Translation: CAI14603.1.
AL513485 Genomic DNA. Translation: CAI14604.1. Different initiation.
AL513485 Genomic DNA. Translation: CAI14602.1.
CH471121 Genomic DNA. Translation: EAW52760.1.
BC002616 mRNA. Translation: AAH02616.1.
BC009357 mRNA. Translation: AAH09357.1.
CCDSiCCDS1189.1. [P37802-1]
CCDS60314.1. [P37802-2]
RefSeqiNP_001264152.1. NM_001277223.1. [P37802-1]
NP_001264153.1. NM_001277224.1. [P37802-2]
NP_003555.1. NM_003564.2. [P37802-1]
UniGeneiHs.517168.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WYMNMR-A16-157[»]
ProteinModelPortaliP37802.
SMRiP37802.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113995. 118 interactors.
IntActiP37802. 19 interactors.
MINTiMINT-5001664.
STRINGi9606.ENSP00000357075.

PTM databases

iPTMnetiP37802.
PhosphoSitePlusiP37802.
SwissPalmiP37802.

Polymorphism and mutation databases

DMDMi586000.

2D gel databases

DOSAC-COBS-2DPAGEP37802.
OGPiP37802.
REPRODUCTION-2DPAGEP37802.

Proteomic databases

EPDiP37802.
MaxQBiP37802.
PaxDbiP37802.
PeptideAtlasiP37802.
PRIDEiP37802.
TopDownProteomicsiP37802-1. [P37802-1]

Protocols and materials databases

DNASUi8407.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320307; ENSP00000357075; ENSG00000158710. [P37802-1]
ENST00000368096; ENSP00000357076; ENSG00000158710. [P37802-2]
ENST00000368097; ENSP00000357077; ENSG00000158710. [P37802-1]
GeneIDi8407.
KEGGihsa:8407.
UCSCiuc001fun.3. human. [P37802-1]

Organism-specific databases

CTDi8407.
DisGeNETi8407.
GeneCardsiTAGLN2.
HGNCiHGNC:11554. TAGLN2.
HPAiHPA001925.
MIMi604634. gene.
neXtProtiNX_P37802.
OpenTargetsiENSG00000158710.
PharmGKBiPA36325.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiP37802.
KOiK20526.
OMAiFRMANRG.
OrthoDBiEOG091G0LY2.
PhylomeDBiP37802.
TreeFamiTF313921.

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiTAGLN2. human.
EvolutionaryTraceiP37802.
GeneWikiiTAGLN2.
GenomeRNAii8407.
PROiP37802.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158710.
CleanExiHS_TAGLN2.
ExpressionAtlasiP37802. baseline and differential.
GenevisibleiP37802. HS.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAGL2_HUMAN
AccessioniPrimary (citable) accession number: P37802
Secondary accession number(s): E9KL39
, Q5JRQ6, Q5JRQ7, Q6FGI1, Q9BUH5, Q9H4P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 173 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.