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P37800

- L_TOSV

UniProt

P37800 - L_TOSV

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Protein
RNA-directed RNA polymerase L
Gene
L
Organism
Toscana virus (Tos)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  2. nucleoside binding Source: InterPro
  3. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiToscana virus (Tos)
Taxonomic identifieri11590 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Phlebotomus perniciosus [TaxID: 13204]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20952095RNA-directed RNA polymerase L
PRO_0000222025Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini976 – 1167192RdRp catalytic
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view]
PIRSFiPIRSF000826. L_PhleboV. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37800-1 [UniParc]FASTAAdd to Basket

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MERILKKQPA PVRALTIHPL RRYESSIYDT PIPAYVIKHS SDGVTIDIAT     50
SELADGQSGS TIQPFESVPA QNLTLFKHDF TFGHLADTTD KKFVEVFGVL 100
ENRADDSDFQ SPDMIIETET GHVYVVEFTT TMGDANSADL AARNKIAKYE 150
IACLNRSAIK PISLYIIAVH FNGVISNLDL SDEEVNEIVF RFRLARDIFE 200
ELREINPALF DSDETISRLE REVNSVMSAI QIDWDTTEKK FPSFRRELFE 250
NFRSKEVDDE YISKIIKRCT DEALRGIERD SLYTEDITNK ERFELNSKRA 300
ASDIKNKMAE MMSYEFLRDT EDHKSTVQFP PWVTRTGPAG KDLEPLKSVS 350
VEGSHPMCKI WNKVCTNASI EKIERMHDDP VLELEYAMSG STERSVERNK 400
YHRTVLTLSP EEREYAAVLG VCGKRNANLG AVKEARVRSK KGFSIGHNTE 450
RVEEFLSDSC VEDLIPTEGL YNPLSEDKSL RLLAMGLHQP TLIHMDDETP 500
ETLDCHLKFL SSPIGSWLQM VSIVGAELSA SVKQHVKPNQ FIVKRLLDSA 550
IFLLIKPTTS KGHIFVSLAV NKKFLHGELS KSSVFKQSID AGDLLVTDFV 600
SFKLSKITNL CKALCVLEAA SCFWAETYGF EPWKFVDQAS AVKFLDAWFM 650
IKLSLLTMLE DKATTEELQT MQRYVIMEGF VSLPEIPKPH KMLSKIPKVL 700
RSELQVFLTH RLFSTMQRIS ATPFQLHKVG GNIRWKGLFN PYSGNSIDEL 750
QTLISCCYNG YFKNKEEDTE PSALSAMYKK IIELEHLRPP TDTYLGYEDP 800
IDPKMHEFSR SYLKLLCNHA KTKLRKQYGR GVMNQIENSI VREVQSITLE 850
RLATLKATSN FDDSWYTFKD VKDKNYTRDK LLVKMTQFAH RGKTLAIEVF 900
EECMSRIEEK GCMEICLFKK QQHGGLREIY VMGADERIVQ SVIEAIARAI 950
GRFFDSDTLC NPSNKIRIPE THGQRAKRRC GRSVWTCATS DDARKWNQGH 1000
YVTKFALMLC EFTPQEWWPL IIRGCSMFTN KFMMMNLDFL RIIDSHKELQ 1050
IEDEFVSKLF KAYHGESVEP WISQGCTYLK TSTGMMQGIL HFTSSLLHSL 1100
HQEFVKTTAI QLFTLKLGSD ASSKVVCDMM QGSDDSSMII SFPSYNEKIK 1150
MRYKLVAAMC FRIKKSLGIY IGIYPSEKST PNTDFVMEYN SEFFFHSQHV 1200
RPTIRWIAAS CSLPEVETLV ASKEEAANLL TAITEGGGSF SLAAMIQHCQ 1250
SSIHYMLMGL GVSALFSEFS KAISKWLDPG LGFFLFDNPY SAGLSGFKYN 1300
LYRAIMNSSL KSIYSFFMKR VKGGSQRTDG IISESCSVSP GGAIVMSSTL 1350
RWGSVEKFKR LRNRLNIPET WKEMINESPE VLYRAPQTGT EIMLRIAEKV 1400
HSPGVVSSLS TGNAVCKVMA SSVYFLSACI FEDAGSQEYK VVNNDKYSLM 1450
QKIIAFDQIG CNDEISQEDL LFLFPNLAEF EAFDSIIYDK GRFNVIPRAS 1500
QREATQTRIV VFEHHSSARV APEKLVSDKW FGTRKSKIGS PGFRQEWDRL 1550
KAIVRWLRDT PEETLDSSPF SNHIQIRNFF ARMEGRPRVI KVTGAPVKRD 1600
LGMSKIAMAI RDNFCKTGFL QGLEDEVGHS RAMQVEKIKH YLFSVLMGPY 1650
SEEAKLEYVV KILKEEPQVI LNYNDKRSRA NIISLLQRFI KSEIGIATLI 1700
EDMKAGVFGA FVKAQQFSQS SVNNKYYGRG IWKGVMDGYQ VQIDIDGKEG 1750
MPSHLSGITI SNCSKTWILT QSLKAWCEDM QVYNNTDVSK ANPKANYWMY 1800
GFKMYGSSYP YGCPIYLVRH DITNLGLLHD DDIDIKVRRN TINLFVRSKD 1850
KRPRDLHILS YTPSDSDISS VSSKHIMEDE YFVYKGAFSV EPTRSWMLCQ 1900
PLPWSFVRPV LQVATGSRRS PRQLDLERLR EIIRLCTESS IRNKVGTVYG 1950
QNRPEKFIEA EPIDMSEMFD MMLDEGMDDA FEELADYLTV EEDPDYMDEV 2000
SFDDDSLNLF GPAHYKELQS LTVLAHPLMD DFVTRLVGKM GRPQIRRLLE 2050
KNVTTRDLRE LSELLFMALD RDPSQIREEL ILGDSPTEVP DDLLG 2095
Length:2,095
Mass (Da):238,887
Last modified:October 1, 1994 - v1
Checksum:i22FF4DAD745583B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68414 Genomic RNA. Translation: CAA48478.1.
PIRiS29529.
RefSeqiYP_089669.1. NC_006319.1.

Genome annotation databases

GeneIDi3077272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68414 Genomic RNA. Translation: CAA48478.1 .
PIRi S29529.
RefSeqi YP_089669.1. NC_006319.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3077272.

Family and domain databases

InterProi IPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view ]
PIRSFi PIRSF000826. L_PhleboV. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Toscana virus genomic L segment: molecular cloning, coding strategy and amino acid sequence in comparison with other negative strand RNA viruses."
    Accardi L., Gro M.C., di Bonito P., Giorgi C.
    Virus Res. 27:119-131(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: ISS.PHL.3.

Entry informationi

Entry nameiL_TOSV
AccessioniPrimary (citable) accession number: P37800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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