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P37800

- L_TOSV

UniProt

P37800 - L_TOSV

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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Toscana virus (Tos)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleoside binding Source: InterPro
  2. nucleotide binding Source: UniProtKB-KW
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiToscana virus (Tos)
Taxonomic identifieri11590 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Phlebotomus perniciosus [TaxID: 13204]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20952095RNA-directed RNA polymerase LPRO_0000222025Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini976 – 1167192RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phlebovirus RNA polymerase family.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view]
PIRSFiPIRSF000826. L_PhleboV. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37800-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MERILKKQPA PVRALTIHPL RRYESSIYDT PIPAYVIKHS SDGVTIDIAT
60 70 80 90 100
SELADGQSGS TIQPFESVPA QNLTLFKHDF TFGHLADTTD KKFVEVFGVL
110 120 130 140 150
ENRADDSDFQ SPDMIIETET GHVYVVEFTT TMGDANSADL AARNKIAKYE
160 170 180 190 200
IACLNRSAIK PISLYIIAVH FNGVISNLDL SDEEVNEIVF RFRLARDIFE
210 220 230 240 250
ELREINPALF DSDETISRLE REVNSVMSAI QIDWDTTEKK FPSFRRELFE
260 270 280 290 300
NFRSKEVDDE YISKIIKRCT DEALRGIERD SLYTEDITNK ERFELNSKRA
310 320 330 340 350
ASDIKNKMAE MMSYEFLRDT EDHKSTVQFP PWVTRTGPAG KDLEPLKSVS
360 370 380 390 400
VEGSHPMCKI WNKVCTNASI EKIERMHDDP VLELEYAMSG STERSVERNK
410 420 430 440 450
YHRTVLTLSP EEREYAAVLG VCGKRNANLG AVKEARVRSK KGFSIGHNTE
460 470 480 490 500
RVEEFLSDSC VEDLIPTEGL YNPLSEDKSL RLLAMGLHQP TLIHMDDETP
510 520 530 540 550
ETLDCHLKFL SSPIGSWLQM VSIVGAELSA SVKQHVKPNQ FIVKRLLDSA
560 570 580 590 600
IFLLIKPTTS KGHIFVSLAV NKKFLHGELS KSSVFKQSID AGDLLVTDFV
610 620 630 640 650
SFKLSKITNL CKALCVLEAA SCFWAETYGF EPWKFVDQAS AVKFLDAWFM
660 670 680 690 700
IKLSLLTMLE DKATTEELQT MQRYVIMEGF VSLPEIPKPH KMLSKIPKVL
710 720 730 740 750
RSELQVFLTH RLFSTMQRIS ATPFQLHKVG GNIRWKGLFN PYSGNSIDEL
760 770 780 790 800
QTLISCCYNG YFKNKEEDTE PSALSAMYKK IIELEHLRPP TDTYLGYEDP
810 820 830 840 850
IDPKMHEFSR SYLKLLCNHA KTKLRKQYGR GVMNQIENSI VREVQSITLE
860 870 880 890 900
RLATLKATSN FDDSWYTFKD VKDKNYTRDK LLVKMTQFAH RGKTLAIEVF
910 920 930 940 950
EECMSRIEEK GCMEICLFKK QQHGGLREIY VMGADERIVQ SVIEAIARAI
960 970 980 990 1000
GRFFDSDTLC NPSNKIRIPE THGQRAKRRC GRSVWTCATS DDARKWNQGH
1010 1020 1030 1040 1050
YVTKFALMLC EFTPQEWWPL IIRGCSMFTN KFMMMNLDFL RIIDSHKELQ
1060 1070 1080 1090 1100
IEDEFVSKLF KAYHGESVEP WISQGCTYLK TSTGMMQGIL HFTSSLLHSL
1110 1120 1130 1140 1150
HQEFVKTTAI QLFTLKLGSD ASSKVVCDMM QGSDDSSMII SFPSYNEKIK
1160 1170 1180 1190 1200
MRYKLVAAMC FRIKKSLGIY IGIYPSEKST PNTDFVMEYN SEFFFHSQHV
1210 1220 1230 1240 1250
RPTIRWIAAS CSLPEVETLV ASKEEAANLL TAITEGGGSF SLAAMIQHCQ
1260 1270 1280 1290 1300
SSIHYMLMGL GVSALFSEFS KAISKWLDPG LGFFLFDNPY SAGLSGFKYN
1310 1320 1330 1340 1350
LYRAIMNSSL KSIYSFFMKR VKGGSQRTDG IISESCSVSP GGAIVMSSTL
1360 1370 1380 1390 1400
RWGSVEKFKR LRNRLNIPET WKEMINESPE VLYRAPQTGT EIMLRIAEKV
1410 1420 1430 1440 1450
HSPGVVSSLS TGNAVCKVMA SSVYFLSACI FEDAGSQEYK VVNNDKYSLM
1460 1470 1480 1490 1500
QKIIAFDQIG CNDEISQEDL LFLFPNLAEF EAFDSIIYDK GRFNVIPRAS
1510 1520 1530 1540 1550
QREATQTRIV VFEHHSSARV APEKLVSDKW FGTRKSKIGS PGFRQEWDRL
1560 1570 1580 1590 1600
KAIVRWLRDT PEETLDSSPF SNHIQIRNFF ARMEGRPRVI KVTGAPVKRD
1610 1620 1630 1640 1650
LGMSKIAMAI RDNFCKTGFL QGLEDEVGHS RAMQVEKIKH YLFSVLMGPY
1660 1670 1680 1690 1700
SEEAKLEYVV KILKEEPQVI LNYNDKRSRA NIISLLQRFI KSEIGIATLI
1710 1720 1730 1740 1750
EDMKAGVFGA FVKAQQFSQS SVNNKYYGRG IWKGVMDGYQ VQIDIDGKEG
1760 1770 1780 1790 1800
MPSHLSGITI SNCSKTWILT QSLKAWCEDM QVYNNTDVSK ANPKANYWMY
1810 1820 1830 1840 1850
GFKMYGSSYP YGCPIYLVRH DITNLGLLHD DDIDIKVRRN TINLFVRSKD
1860 1870 1880 1890 1900
KRPRDLHILS YTPSDSDISS VSSKHIMEDE YFVYKGAFSV EPTRSWMLCQ
1910 1920 1930 1940 1950
PLPWSFVRPV LQVATGSRRS PRQLDLERLR EIIRLCTESS IRNKVGTVYG
1960 1970 1980 1990 2000
QNRPEKFIEA EPIDMSEMFD MMLDEGMDDA FEELADYLTV EEDPDYMDEV
2010 2020 2030 2040 2050
SFDDDSLNLF GPAHYKELQS LTVLAHPLMD DFVTRLVGKM GRPQIRRLLE
2060 2070 2080 2090
KNVTTRDLRE LSELLFMALD RDPSQIREEL ILGDSPTEVP DDLLG
Length:2,095
Mass (Da):238,887
Last modified:October 1, 1994 - v1
Checksum:i22FF4DAD745583B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68414 Genomic RNA. Translation: CAA48478.1.
PIRiS29529.
RefSeqiYP_089669.1. NC_006319.1.

Genome annotation databases

GeneIDi3077272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68414 Genomic RNA. Translation: CAA48478.1 .
PIRi S29529.
RefSeqi YP_089669.1. NC_006319.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3077272.

Family and domain databases

InterProi IPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view ]
PIRSFi PIRSF000826. L_PhleboV. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Toscana virus genomic L segment: molecular cloning, coding strategy and amino acid sequence in comparison with other negative strand RNA viruses."
    Accardi L., Gro M.C., di Bonito P., Giorgi C.
    Virus Res. 27:119-131(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: ISS.PHL.3.

Entry informationi

Entry nameiL_TOSV
AccessioniPrimary (citable) accession number: P37800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 1, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3