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P37800

- L_TOSV

UniProt

P37800 - L_TOSV

Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Toscana virus (Tos)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleoside binding Source: InterPro
    2. nucleotide binding Source: UniProtKB-KW
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro
    2. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase L (EC:2.7.7.48)
    Short name:
    Protein L
    Alternative name(s):
    Large structural protein
    Replicase
    Transcriptase
    Gene namesi
    Name:L
    OrganismiToscana virus (Tos)
    Taxonomic identifieri11590 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Phlebotomus perniciosus [TaxID: 13204]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20952095RNA-directed RNA polymerase LPRO_0000222025Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini976 – 1167192RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the phlebovirus RNA polymerase family.Curated
    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR022531. DUF3770.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR014385. RNA-dir_pol_phlebovirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view]
    PfamiPF04196. Bunya_RdRp. 1 hit.
    PF12603. DUF3770. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000826. L_PhleboV. 1 hit.
    PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37800-1 [UniParc]FASTAAdd to Basket

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    MERILKKQPA PVRALTIHPL RRYESSIYDT PIPAYVIKHS SDGVTIDIAT     50
    SELADGQSGS TIQPFESVPA QNLTLFKHDF TFGHLADTTD KKFVEVFGVL 100
    ENRADDSDFQ SPDMIIETET GHVYVVEFTT TMGDANSADL AARNKIAKYE 150
    IACLNRSAIK PISLYIIAVH FNGVISNLDL SDEEVNEIVF RFRLARDIFE 200
    ELREINPALF DSDETISRLE REVNSVMSAI QIDWDTTEKK FPSFRRELFE 250
    NFRSKEVDDE YISKIIKRCT DEALRGIERD SLYTEDITNK ERFELNSKRA 300
    ASDIKNKMAE MMSYEFLRDT EDHKSTVQFP PWVTRTGPAG KDLEPLKSVS 350
    VEGSHPMCKI WNKVCTNASI EKIERMHDDP VLELEYAMSG STERSVERNK 400
    YHRTVLTLSP EEREYAAVLG VCGKRNANLG AVKEARVRSK KGFSIGHNTE 450
    RVEEFLSDSC VEDLIPTEGL YNPLSEDKSL RLLAMGLHQP TLIHMDDETP 500
    ETLDCHLKFL SSPIGSWLQM VSIVGAELSA SVKQHVKPNQ FIVKRLLDSA 550
    IFLLIKPTTS KGHIFVSLAV NKKFLHGELS KSSVFKQSID AGDLLVTDFV 600
    SFKLSKITNL CKALCVLEAA SCFWAETYGF EPWKFVDQAS AVKFLDAWFM 650
    IKLSLLTMLE DKATTEELQT MQRYVIMEGF VSLPEIPKPH KMLSKIPKVL 700
    RSELQVFLTH RLFSTMQRIS ATPFQLHKVG GNIRWKGLFN PYSGNSIDEL 750
    QTLISCCYNG YFKNKEEDTE PSALSAMYKK IIELEHLRPP TDTYLGYEDP 800
    IDPKMHEFSR SYLKLLCNHA KTKLRKQYGR GVMNQIENSI VREVQSITLE 850
    RLATLKATSN FDDSWYTFKD VKDKNYTRDK LLVKMTQFAH RGKTLAIEVF 900
    EECMSRIEEK GCMEICLFKK QQHGGLREIY VMGADERIVQ SVIEAIARAI 950
    GRFFDSDTLC NPSNKIRIPE THGQRAKRRC GRSVWTCATS DDARKWNQGH 1000
    YVTKFALMLC EFTPQEWWPL IIRGCSMFTN KFMMMNLDFL RIIDSHKELQ 1050
    IEDEFVSKLF KAYHGESVEP WISQGCTYLK TSTGMMQGIL HFTSSLLHSL 1100
    HQEFVKTTAI QLFTLKLGSD ASSKVVCDMM QGSDDSSMII SFPSYNEKIK 1150
    MRYKLVAAMC FRIKKSLGIY IGIYPSEKST PNTDFVMEYN SEFFFHSQHV 1200
    RPTIRWIAAS CSLPEVETLV ASKEEAANLL TAITEGGGSF SLAAMIQHCQ 1250
    SSIHYMLMGL GVSALFSEFS KAISKWLDPG LGFFLFDNPY SAGLSGFKYN 1300
    LYRAIMNSSL KSIYSFFMKR VKGGSQRTDG IISESCSVSP GGAIVMSSTL 1350
    RWGSVEKFKR LRNRLNIPET WKEMINESPE VLYRAPQTGT EIMLRIAEKV 1400
    HSPGVVSSLS TGNAVCKVMA SSVYFLSACI FEDAGSQEYK VVNNDKYSLM 1450
    QKIIAFDQIG CNDEISQEDL LFLFPNLAEF EAFDSIIYDK GRFNVIPRAS 1500
    QREATQTRIV VFEHHSSARV APEKLVSDKW FGTRKSKIGS PGFRQEWDRL 1550
    KAIVRWLRDT PEETLDSSPF SNHIQIRNFF ARMEGRPRVI KVTGAPVKRD 1600
    LGMSKIAMAI RDNFCKTGFL QGLEDEVGHS RAMQVEKIKH YLFSVLMGPY 1650
    SEEAKLEYVV KILKEEPQVI LNYNDKRSRA NIISLLQRFI KSEIGIATLI 1700
    EDMKAGVFGA FVKAQQFSQS SVNNKYYGRG IWKGVMDGYQ VQIDIDGKEG 1750
    MPSHLSGITI SNCSKTWILT QSLKAWCEDM QVYNNTDVSK ANPKANYWMY 1800
    GFKMYGSSYP YGCPIYLVRH DITNLGLLHD DDIDIKVRRN TINLFVRSKD 1850
    KRPRDLHILS YTPSDSDISS VSSKHIMEDE YFVYKGAFSV EPTRSWMLCQ 1900
    PLPWSFVRPV LQVATGSRRS PRQLDLERLR EIIRLCTESS IRNKVGTVYG 1950
    QNRPEKFIEA EPIDMSEMFD MMLDEGMDDA FEELADYLTV EEDPDYMDEV 2000
    SFDDDSLNLF GPAHYKELQS LTVLAHPLMD DFVTRLVGKM GRPQIRRLLE 2050
    KNVTTRDLRE LSELLFMALD RDPSQIREEL ILGDSPTEVP DDLLG 2095
    Length:2,095
    Mass (Da):238,887
    Last modified:October 1, 1994 - v1
    Checksum:i22FF4DAD745583B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68414 Genomic RNA. Translation: CAA48478.1.
    PIRiS29529.
    RefSeqiYP_089669.1. NC_006319.1.

    Genome annotation databases

    GeneIDi3077272.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68414 Genomic RNA. Translation: CAA48478.1 .
    PIRi S29529.
    RefSeqi YP_089669.1. NC_006319.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3077272.

    Family and domain databases

    InterProi IPR022531. DUF3770.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR014385. RNA-dir_pol_phlebovirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view ]
    Pfami PF04196. Bunya_RdRp. 1 hit.
    PF12603. DUF3770. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000826. L_PhleboV. 1 hit.
    PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Toscana virus genomic L segment: molecular cloning, coding strategy and amino acid sequence in comparison with other negative strand RNA viruses."
      Accardi L., Gro M.C., di Bonito P., Giorgi C.
      Virus Res. 27:119-131(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: ISS.PHL.3.

    Entry informationi

    Entry nameiL_TOSV
    AccessioniPrimary (citable) accession number: P37800
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3