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P37800 (L_TOSV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase L

Short name=Protein L
EC=2.7.7.48
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene names
Name:L
OrganismToscana virus (Tos)
Taxonomic identifier11590 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]
Phlebotomus perniciosus [TaxID: 13204]

Protein attributes

Sequence length2095 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sequence similarities

Belongs to the phlebovirus RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 20952095RNA-directed RNA polymerase L
PRO_0000222025

Regions

Domain976 – 1167192RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
P37800 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 22FF4DAD745583B7

FASTA2,095238,887
        10         20         30         40         50         60 
MERILKKQPA PVRALTIHPL RRYESSIYDT PIPAYVIKHS SDGVTIDIAT SELADGQSGS 

        70         80         90        100        110        120 
TIQPFESVPA QNLTLFKHDF TFGHLADTTD KKFVEVFGVL ENRADDSDFQ SPDMIIETET 

       130        140        150        160        170        180 
GHVYVVEFTT TMGDANSADL AARNKIAKYE IACLNRSAIK PISLYIIAVH FNGVISNLDL 

       190        200        210        220        230        240 
SDEEVNEIVF RFRLARDIFE ELREINPALF DSDETISRLE REVNSVMSAI QIDWDTTEKK 

       250        260        270        280        290        300 
FPSFRRELFE NFRSKEVDDE YISKIIKRCT DEALRGIERD SLYTEDITNK ERFELNSKRA 

       310        320        330        340        350        360 
ASDIKNKMAE MMSYEFLRDT EDHKSTVQFP PWVTRTGPAG KDLEPLKSVS VEGSHPMCKI 

       370        380        390        400        410        420 
WNKVCTNASI EKIERMHDDP VLELEYAMSG STERSVERNK YHRTVLTLSP EEREYAAVLG 

       430        440        450        460        470        480 
VCGKRNANLG AVKEARVRSK KGFSIGHNTE RVEEFLSDSC VEDLIPTEGL YNPLSEDKSL 

       490        500        510        520        530        540 
RLLAMGLHQP TLIHMDDETP ETLDCHLKFL SSPIGSWLQM VSIVGAELSA SVKQHVKPNQ 

       550        560        570        580        590        600 
FIVKRLLDSA IFLLIKPTTS KGHIFVSLAV NKKFLHGELS KSSVFKQSID AGDLLVTDFV 

       610        620        630        640        650        660 
SFKLSKITNL CKALCVLEAA SCFWAETYGF EPWKFVDQAS AVKFLDAWFM IKLSLLTMLE 

       670        680        690        700        710        720 
DKATTEELQT MQRYVIMEGF VSLPEIPKPH KMLSKIPKVL RSELQVFLTH RLFSTMQRIS 

       730        740        750        760        770        780 
ATPFQLHKVG GNIRWKGLFN PYSGNSIDEL QTLISCCYNG YFKNKEEDTE PSALSAMYKK 

       790        800        810        820        830        840 
IIELEHLRPP TDTYLGYEDP IDPKMHEFSR SYLKLLCNHA KTKLRKQYGR GVMNQIENSI 

       850        860        870        880        890        900 
VREVQSITLE RLATLKATSN FDDSWYTFKD VKDKNYTRDK LLVKMTQFAH RGKTLAIEVF 

       910        920        930        940        950        960 
EECMSRIEEK GCMEICLFKK QQHGGLREIY VMGADERIVQ SVIEAIARAI GRFFDSDTLC 

       970        980        990       1000       1010       1020 
NPSNKIRIPE THGQRAKRRC GRSVWTCATS DDARKWNQGH YVTKFALMLC EFTPQEWWPL 

      1030       1040       1050       1060       1070       1080 
IIRGCSMFTN KFMMMNLDFL RIIDSHKELQ IEDEFVSKLF KAYHGESVEP WISQGCTYLK 

      1090       1100       1110       1120       1130       1140 
TSTGMMQGIL HFTSSLLHSL HQEFVKTTAI QLFTLKLGSD ASSKVVCDMM QGSDDSSMII 

      1150       1160       1170       1180       1190       1200 
SFPSYNEKIK MRYKLVAAMC FRIKKSLGIY IGIYPSEKST PNTDFVMEYN SEFFFHSQHV 

      1210       1220       1230       1240       1250       1260 
RPTIRWIAAS CSLPEVETLV ASKEEAANLL TAITEGGGSF SLAAMIQHCQ SSIHYMLMGL 

      1270       1280       1290       1300       1310       1320 
GVSALFSEFS KAISKWLDPG LGFFLFDNPY SAGLSGFKYN LYRAIMNSSL KSIYSFFMKR 

      1330       1340       1350       1360       1370       1380 
VKGGSQRTDG IISESCSVSP GGAIVMSSTL RWGSVEKFKR LRNRLNIPET WKEMINESPE 

      1390       1400       1410       1420       1430       1440 
VLYRAPQTGT EIMLRIAEKV HSPGVVSSLS TGNAVCKVMA SSVYFLSACI FEDAGSQEYK 

      1450       1460       1470       1480       1490       1500 
VVNNDKYSLM QKIIAFDQIG CNDEISQEDL LFLFPNLAEF EAFDSIIYDK GRFNVIPRAS 

      1510       1520       1530       1540       1550       1560 
QREATQTRIV VFEHHSSARV APEKLVSDKW FGTRKSKIGS PGFRQEWDRL KAIVRWLRDT 

      1570       1580       1590       1600       1610       1620 
PEETLDSSPF SNHIQIRNFF ARMEGRPRVI KVTGAPVKRD LGMSKIAMAI RDNFCKTGFL 

      1630       1640       1650       1660       1670       1680 
QGLEDEVGHS RAMQVEKIKH YLFSVLMGPY SEEAKLEYVV KILKEEPQVI LNYNDKRSRA 

      1690       1700       1710       1720       1730       1740 
NIISLLQRFI KSEIGIATLI EDMKAGVFGA FVKAQQFSQS SVNNKYYGRG IWKGVMDGYQ 

      1750       1760       1770       1780       1790       1800 
VQIDIDGKEG MPSHLSGITI SNCSKTWILT QSLKAWCEDM QVYNNTDVSK ANPKANYWMY 

      1810       1820       1830       1840       1850       1860 
GFKMYGSSYP YGCPIYLVRH DITNLGLLHD DDIDIKVRRN TINLFVRSKD KRPRDLHILS 

      1870       1880       1890       1900       1910       1920 
YTPSDSDISS VSSKHIMEDE YFVYKGAFSV EPTRSWMLCQ PLPWSFVRPV LQVATGSRRS 

      1930       1940       1950       1960       1970       1980 
PRQLDLERLR EIIRLCTESS IRNKVGTVYG QNRPEKFIEA EPIDMSEMFD MMLDEGMDDA 

      1990       2000       2010       2020       2030       2040 
FEELADYLTV EEDPDYMDEV SFDDDSLNLF GPAHYKELQS LTVLAHPLMD DFVTRLVGKM 

      2050       2060       2070       2080       2090 
GRPQIRRLLE KNVTTRDLRE LSELLFMALD RDPSQIREEL ILGDSPTEVP DDLLG 

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References

[1]"Toscana virus genomic L segment: molecular cloning, coding strategy and amino acid sequence in comparison with other negative strand RNA viruses."
Accardi L., Gro M.C., di Bonito P., Giorgi C.
Virus Res. 27:119-131(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: ISS.PHL.3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68414 Genomic RNA. Translation: CAA48478.1.
PIRS29529.
RefSeqYP_089669.1. NC_006319.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3077272.

Family and domain databases

InterProIPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamPF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view]
PIRSFPIRSF000826. L_PhleboV. 1 hit.
PROSITEPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameL_TOSV
AccessionPrimary (citable) accession number: P37800
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families