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P37798

- ACCC_PSEAE

UniProt

P37798 - ACCC_PSEAE

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Protein

Biotin carboxylase

Gene

accC

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.By similarity

Catalytic activityi

ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161ATPBy similarity
Binding sitei201 – 2011ATPBy similarity
Binding sitei236 – 2361ATPBy similarity
Active sitei292 – 2921Sequence Analysis

GO - Molecular functioni

  1. acetyl-CoA carboxylase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. biotin carboxylase activity Source: UniProtKB-EC
  4. metal ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
  2. malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Biotin, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxylase (EC:6.3.4.14)
Alternative name(s):
Acetyl-CoA carboxylase subunit A (EC:6.4.1.2)
Short name:
ACC
Gene namesi
Name:accC
Synonyms:fabG
Ordered Locus Names:PA4848
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Biotin carboxylasePRO_0000146794Add
BLAST

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.By similarity

Protein-protein interaction databases

STRINGi208964.PA4848.

Structurei

Secondary structure

1
449
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 75Combined sources
Helixi11 – 2313Combined sources
Beta strandi27 – 337Combined sources
Helixi34 – 363Combined sources
Helixi40 – 445Combined sources
Beta strandi45 – 528Combined sources
Helixi56 – 583Combined sources
Turni59 – 613Combined sources
Helixi63 – 7311Combined sources
Beta strandi76 – 794Combined sources
Turni84 – 874Combined sources
Helixi89 – 979Combined sources
Beta strandi101 – 1055Combined sources
Helixi107 – 1148Combined sources
Helixi116 – 12510Combined sources
Beta strandi135 – 1373Combined sources
Helixi142 – 15211Combined sources
Beta strandi154 – 1607Combined sources
Beta strandi168 – 1747Combined sources
Helixi175 – 1773Combined sources
Helixi178 – 19316Combined sources
Beta strandi198 – 2025Combined sources
Beta strandi208 – 22013Combined sources
Beta strandi222 – 2298Combined sources
Beta strandi240 – 2445Combined sources
Helixi250 – 26718Combined sources
Beta strandi270 – 28011Combined sources
Beta strandi283 – 2908Combined sources
Helixi297 – 3048Combined sources
Helixi308 – 3169Combined sources
Helixi325 – 3273Combined sources
Beta strandi332 – 34211Combined sources
Turni344 – 3463Combined sources
Beta strandi352 – 3587Combined sources
Beta strandi365 – 3695Combined sources
Beta strandi375 – 3773Combined sources
Beta strandi379 – 3813Combined sources
Beta strandi383 – 39412Combined sources
Helixi395 – 40814Combined sources
Beta strandi410 – 4123Combined sources
Helixi418 – 4247Combined sources
Helixi428 – 4325Combined sources
Helixi439 – 4446Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2C00X-ray2.50A/B1-449[»]
2VQDX-ray2.41A1-449[»]
ProteinModelPortaliP37798.
SMRiP37798. Positions 1-447.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37798.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 445445Biotin carboxylationAdd
BLAST
Domaini120 – 317198ATP-graspPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.PROSITE-ProRule annotation
Contains 1 biotin carboxylation domain.Curated

Phylogenomic databases

eggNOGiCOG0439.
HOGENOMiHOG000008988.
InParanoidiP37798.
KOiK01961.
OMAiNIRLMGD.
OrthoDBiEOG6CVV6Z.
PhylomeDBiP37798.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR004549. Acetyl_CoA_COase_biotin_COase.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02785. Biotin_carb_C. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR00514. accC. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37798-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEKVLIANR GEIALRILRA CKELGIKTVA VHSTADRELM HLSLADESVC
60 70 80 90 100
IGPAPATQSY LQIPAIIAAA EVTGATAIHP GYGFLAENAD FAEQIERSGF
110 120 130 140 150
TFVGPTAEVI RLMGDKVSAK DAMKRAGVPT VPGSDGPLPE DEETALAIAR
160 170 180 190 200
EVGYPVIIKA AGGGGGRGMR VVYDESELIK SAKLTRTEAG AAFGNPMVYL
210 220 230 240 250
EKFLTNPRHV EVQVLSDGQG NAIHLGDRDC SLQRRHQKVI EEAPAPGIDE
260 270 280 290 300
KARQEVFARC VQACIEIGYR GAGTFEFLYE NGRFYFIEMN TRVQVEHPVS
310 320 330 340 350
EMVTGVDIVK EMLRIASGEK LSIRQEDVVI RGHALECRIN AEDPKTFMPS
360 370 380 390 400
PGKVKHFHAP GGNGVRVDSH LYSGYSVPPN YDSLVGKVIT YGADRDEALA
410 420 430 440
RMRNALDELI VDGIKTNTEL HKDLVRDAAF CKGGVNIHYL EKKLGMDKH
Length:449
Mass (Da):48,888
Last modified:October 1, 1994 - v1
Checksum:i3B04C77785C73541
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14612 Unassigned DNA. Translation: AAA16041.1.
AE004091 Genomic DNA. Translation: AAG08233.1.
PIRiB49342.
RefSeqiNP_253535.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08233; AAG08233; PA4848.
GeneIDi879558.
KEGGipae:PA4848.
PATRICi19844497. VBIPseAer58763_5080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14612 Unassigned DNA. Translation: AAA16041.1 .
AE004091 Genomic DNA. Translation: AAG08233.1 .
PIRi B49342.
RefSeqi NP_253535.1. NC_002516.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2C00 X-ray 2.50 A/B 1-449 [» ]
2VQD X-ray 2.41 A 1-449 [» ]
ProteinModelPortali P37798.
SMRi P37798. Positions 1-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA4848.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08233 ; AAG08233 ; PA4848 .
GeneIDi 879558.
KEGGi pae:PA4848.
PATRICi 19844497. VBIPseAer58763_5080.

Organism-specific databases

PseudoCAPi PA4848.

Phylogenomic databases

eggNOGi COG0439.
HOGENOMi HOG000008988.
InParanoidi P37798.
KOi K01961.
OMAi NIRLMGD.
OrthoDBi EOG6CVV6Z.
PhylomeDBi P37798.

Enzyme and pathway databases

UniPathwayi UPA00655 ; UER00711 .

Miscellaneous databases

EvolutionaryTracei P37798.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR004549. Acetyl_CoA_COase_biotin_COase.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02785. Biotin_carb_C. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view ]
SMARTi SM00878. Biotin_carb_C. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR00514. accC. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Organization and nucleotide sequences of the genes encoding the biotin carboxyl carrier protein and biotin carboxylase protein of Pseudomonas aeruginosa acetyl coenzyme A carboxylase."
    Best E.A., Knauf V.C.
    J. Bacteriol. 175:6881-6889(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiACCC_PSEAE
AccessioniPrimary (citable) accession number: P37798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 26, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3