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P37798

- ACCC_PSEAE

UniProt

P37798 - ACCC_PSEAE

Protein

Biotin carboxylase

Gene

accC

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.By similarity

    Catalytic activityi

    ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].
    ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei116 – 1161ATPBy similarity
    Binding sitei201 – 2011ATPBy similarity
    Binding sitei236 – 2361ATPBy similarity
    Active sitei292 – 2921Sequence Analysis

    GO - Molecular functioni

    1. acetyl-CoA carboxylase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. biotin carboxylase activity Source: UniProtKB-EC
    4. metal ion binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW
    2. malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Biotin, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00655; UER00711.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biotin carboxylase (EC:6.3.4.14)
    Alternative name(s):
    Acetyl-CoA carboxylase subunit A (EC:6.4.1.2)
    Short name:
    ACC
    Gene namesi
    Name:accC
    Synonyms:fabG
    Ordered Locus Names:PA4848
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA4848.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Biotin carboxylasePRO_0000146794Add
    BLAST

    Interactioni

    Subunit structurei

    Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.By similarity

    Protein-protein interaction databases

    STRINGi208964.PA4848.

    Structurei

    Secondary structure

    1
    449
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 75
    Helixi11 – 2313
    Beta strandi27 – 337
    Helixi34 – 363
    Helixi40 – 445
    Beta strandi45 – 528
    Helixi56 – 583
    Turni59 – 613
    Helixi63 – 7311
    Beta strandi76 – 794
    Turni84 – 874
    Helixi89 – 979
    Beta strandi101 – 1055
    Helixi107 – 1148
    Helixi116 – 12510
    Beta strandi135 – 1373
    Helixi142 – 15211
    Beta strandi154 – 1607
    Beta strandi168 – 1747
    Helixi175 – 1773
    Helixi178 – 19316
    Beta strandi198 – 2025
    Beta strandi208 – 22013
    Beta strandi222 – 2298
    Beta strandi240 – 2445
    Helixi250 – 26718
    Beta strandi270 – 28011
    Beta strandi283 – 2908
    Helixi297 – 3048
    Helixi308 – 3169
    Helixi325 – 3273
    Beta strandi332 – 34211
    Turni344 – 3463
    Beta strandi352 – 3587
    Beta strandi365 – 3695
    Beta strandi375 – 3773
    Beta strandi379 – 3813
    Beta strandi383 – 39412
    Helixi395 – 40814
    Beta strandi410 – 4123
    Helixi418 – 4247
    Helixi428 – 4325
    Helixi439 – 4446

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2C00X-ray2.50A/B1-449[»]
    2VQDX-ray2.41A1-449[»]
    ProteinModelPortaliP37798.
    SMRiP37798. Positions 1-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP37798.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 445445Biotin carboxylationAdd
    BLAST
    Domaini120 – 317198ATP-graspPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ATP-grasp domain.PROSITE-ProRule annotation
    Contains 1 biotin carboxylation domain.Curated

    Phylogenomic databases

    eggNOGiCOG0439.
    HOGENOMiHOG000008988.
    KOiK01961.
    OMAiNIRLMGD.
    OrthoDBiEOG6CVV6Z.
    PhylomeDBiP37798.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProiIPR004549. Acetyl_CoA_COase_biotin_COase.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view]
    PfamiPF02785. Biotin_carb_C. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    [Graphical view]
    SMARTiSM00878. Biotin_carb_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR00514. accC. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS00866. CPSASE_1. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37798-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLEKVLIANR GEIALRILRA CKELGIKTVA VHSTADRELM HLSLADESVC    50
    IGPAPATQSY LQIPAIIAAA EVTGATAIHP GYGFLAENAD FAEQIERSGF 100
    TFVGPTAEVI RLMGDKVSAK DAMKRAGVPT VPGSDGPLPE DEETALAIAR 150
    EVGYPVIIKA AGGGGGRGMR VVYDESELIK SAKLTRTEAG AAFGNPMVYL 200
    EKFLTNPRHV EVQVLSDGQG NAIHLGDRDC SLQRRHQKVI EEAPAPGIDE 250
    KARQEVFARC VQACIEIGYR GAGTFEFLYE NGRFYFIEMN TRVQVEHPVS 300
    EMVTGVDIVK EMLRIASGEK LSIRQEDVVI RGHALECRIN AEDPKTFMPS 350
    PGKVKHFHAP GGNGVRVDSH LYSGYSVPPN YDSLVGKVIT YGADRDEALA 400
    RMRNALDELI VDGIKTNTEL HKDLVRDAAF CKGGVNIHYL EKKLGMDKH 449
    Length:449
    Mass (Da):48,888
    Last modified:October 1, 1994 - v1
    Checksum:i3B04C77785C73541
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14612 Unassigned DNA. Translation: AAA16041.1.
    AE004091 Genomic DNA. Translation: AAG08233.1.
    PIRiB49342.
    RefSeqiNP_253535.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG08233; AAG08233; PA4848.
    GeneIDi879558.
    KEGGipae:PA4848.
    PATRICi19844497. VBIPseAer58763_5080.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14612 Unassigned DNA. Translation: AAA16041.1 .
    AE004091 Genomic DNA. Translation: AAG08233.1 .
    PIRi B49342.
    RefSeqi NP_253535.1. NC_002516.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2C00 X-ray 2.50 A/B 1-449 [» ]
    2VQD X-ray 2.41 A 1-449 [» ]
    ProteinModelPortali P37798.
    SMRi P37798. Positions 1-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA4848.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG08233 ; AAG08233 ; PA4848 .
    GeneIDi 879558.
    KEGGi pae:PA4848.
    PATRICi 19844497. VBIPseAer58763_5080.

    Organism-specific databases

    PseudoCAPi PA4848.

    Phylogenomic databases

    eggNOGi COG0439.
    HOGENOMi HOG000008988.
    KOi K01961.
    OMAi NIRLMGD.
    OrthoDBi EOG6CVV6Z.
    PhylomeDBi P37798.

    Enzyme and pathway databases

    UniPathwayi UPA00655 ; UER00711 .

    Miscellaneous databases

    EvolutionaryTracei P37798.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProi IPR004549. Acetyl_CoA_COase_biotin_COase.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view ]
    Pfami PF02785. Biotin_carb_C. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    [Graphical view ]
    SMARTi SM00878. Biotin_carb_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR00514. accC. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS00866. CPSASE_1. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Organization and nucleotide sequences of the genes encoding the biotin carboxyl carrier protein and biotin carboxylase protein of Pseudomonas aeruginosa acetyl coenzyme A carboxylase."
      Best E.A., Knauf V.C.
      J. Bacteriol. 175:6881-6889(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiACCC_PSEAE
    AccessioniPrimary (citable) accession number: P37798
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3