Reviewed,
UniProtKB/Swiss-Prot P37793 (HIS2_SHIFL)
Last modified
June 16, 2009.
Version 70.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histidine biosynthesis bifunctional protein hisIE Including the following 2 domains: 1- Recommended name: Phosphoribosyl-AMP cyclohydrolase Short name=PRA-CH EC=3.5.4.19 2- Recommended name: Phosphoribosyl-ATP pyrophosphatase Short name=PRA-PH EC=3.6.1.31 | ||||||
| Gene names |
| ||||||
| Organism | Shigella flexneri [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 623 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella |
Protein attributes
| Sequence length | 203 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01019 1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01019 |
| Pathway | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01019 |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | In the N-terminal section; belongs to the PRA-CH family. In the C-terminal section; belongs to the PRA-PH family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Histidine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-AMP cyclohydrolase activityInferred from electronic annotation. Source: HAMAP phosphoribosyl-ATP diphosphatase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 203 | 203 | Histidine biosynthesis bifunctional protein hisIE HAMAP MF_01019 | PRO_0000136429 | ||||
Regions | ||||||||
| Region | 1 – 114 | 114 | Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01019 | |||||
| Region | 115 – 203 | 89 | Phosphoribosyl-ATP pyrophosphohydrolase HAMAP MF_01019 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of the rfc region of Shigella flexneri." Morona R., Mavris M., Fallarino A., Manning P.A. J. Bacteriol. 176:733-747(1994) [PubMed: 7507920] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: PE577 / Serotype 2a. |
| [2] | "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157." Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. Yu J.Nucleic Acids Res. 30:4432-4441(2002) [PubMed: 12384590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 301 / Serotype 2a. |
| [3] | "Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T." Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R. Infect. Immun. 71:2775-2786(2003) [PubMed: 12704152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700930 / 2457T / Serotype 2a. |
Cross-references
Sequence databases | |
|---|---|
| X71970 Genomic DNA. Translation: CAA50784.1. AE005674 Genomic DNA. Translation: AAN43628.1. AE014073 Genomic DNA. Translation: AAP17456.1. | |
| RefSeq | NP_707921.1. NP_837647.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1025295. 1078510. |
| GenomeReviews | Gene locus SF2088 in contig AE005674_GR. Gene locus S2209 in contig AE014073_GR. |
| KEGG | sfl:SF2088. sfx:S2209. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P37793. |
| OMA | P37793. VHYWSRS. |
Enzyme and pathway databases | |
| BioCyc | SFLE198214:AAN43628.1-MON. |
| BRENDA | 3.5.4.19. 189495. 3.6.1.31. 189495. |
Family and domain databases | |
| HAMAP | MF_01019. [Tree] |
| InterPro | IPR002496. PRA_CycHdrlase. IPR008179. PRib-ATP_pyrophosphohydrolase. [Graphical view] |
| Pfam | PF01502. PRA-CH. 1 hit. PF01503. PRA-PH. 1 hit. [Graphical view] |
| ProDom | PD002610. PRA_cyclohydro. 1 hit. PD002611. Pra_PH/CH. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR03188. histidine_hisI. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HIS2_SHIFL | ||||||||
| Accession | Primary (citable) accession number: P37793 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


