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Protein

Putative UDP-glucose 6-dehydrogenase

Gene

udg

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.
Proteins known to be involved in this subpathway in this organism are:
  1. Putative UDP-glucose 6-dehydrogenase (udg)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei253By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi2 – 19NADSequence analysisAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:udg
Ordered Locus Names:SF2090, S2211
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740481 – 372Putative UDP-glucose 6-dehydrogenaseAdd BLAST372

Structurei

3D structure databases

ProteinModelPortaliP37791.
SMRiP37791.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.100. 1 hit.
InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR021157. Cyt_c1_TM_anchor_C.
IPR036291. NAD(P)-bd_dom_sf.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR036220. UDP-Glc/GDP-Man_DH_C_sf.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
PfamiView protein in Pfam
PF00984. UDPG_MGDP_dh. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiView protein in SMART
SM00984. UDPG_MGDP_dh_C. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

P37791-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITISGTGY VGLSNGLLIA QNHEVVALDI LPSRVAMLND RISPIVDKEI
60 70 80 90 100
QQFLQSDKIH FNATLDKNEA YRDADYVIIA TPTDYDPKTN YFNTSSVESV
110 120 130 140 150
IKDVVEINPY AVMVIKSTVP VGFTAAMHKK YRTENIIFSP EFLREGKALY
160 170 180 190 200
DNLHPSRIVI GERSERAERF AALLQEGAIK QNIPTLFTDS TEAEAIKLFA
210 220 230 240 250
NTYLAMRVAY FNELDSYAES LGLNTRQIIE GVCLDPRIGN HYNNPSFGYG
260 270 280 290 300
GYCLPKDTKQ LLANYQSVPN NLISAIVDAN RKWWVFIVIM KSGSDNFRAS
310 320 330 340 350
SIQGIMKRIK AKGVEVIIYE PVMKGDSFFN SRLERDLATF KQQADVIISN
360 370
RMAEELKDVA DKVYTRDLFG SD
Length:372
Mass (Da):41,886
Last modified:October 1, 1994 - v1
Checksum:iDCF6ABB03362AD8D
GO

Sequence cautioni

P37791: The sequence AE005674 differs from that shown. Reason: Frameshift at position 289.Curated
P37791: The sequence AE014073 differs from that shown. Reason: Frameshift at position 289.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti213E → D (PubMed:12384590).Curated1
Sequence conflicti325G → E (PubMed:12384590).Curated1
Sequence conflicti325G → E (PubMed:12704152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71970 Genomic DNA. Translation: CAA50782.1.
AE005674 Genomic DNA. No translation available.
AE014073 Genomic DNA. No translation available.

Similar proteinsi

Entry informationi

Entry nameiUDG_SHIFL
AccessioniPrimary (citable) accession number: P37791
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 25, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families