Reviewed, UniProtKB/Swiss-Prot P37791 (UDG_SHIFL)

Names and origin

Protein names

Recommended name:
    Putative UDP-glucose 6-dehydrogenase
      Short name=UDP-Glc dehydrogenase
      Short name=UDP-GlcDH
      Short name=UDPGDH
    EC=1.1.1.22

Gene names

Name:	udg
Ordered Locus Names:	SF2090, S2211

Organism

Shigella flexneri [Complete proteome] [HAMAP]

Taxonomic identifier

623 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Uncertain.

General annotation (Comments)

Catalytic activity	UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.
Pathway	Nucleotide-sugar biosynthesis; UDP-glucuronate biosynthesis; UDP-glucuronate from UDP-glucose: step 1/1. Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
Sequence similarities	Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
Caution	Could be the product of a pseudogene.
Sequence caution	The sequence AE005674 differs from that shown. Reason: Frameshift at position 289. The sequence AE014073 differs from that shown. Reason: Frameshift at position 289.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro UDP-glucose 6-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	Putative UDP-glucose 6-dehydrogenase		PRO_0000074048
Regions
	Nucleotide binding	2 – 19	18	NAD Potential
Sites
	Active site	253	1	By similarity
Experimental info
	Sequence conflict	213	1	E → D Ref.2
	Sequence conflict	325	1	G → E Ref.2 Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P37791-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: DCF6ABB03362AD8D	FASTA	372	41,886
	10 20 30 40 50 60 MKITISGTGY VGLSNGLLIA QNHEVVALDI LPSRVAMLND RISPIVDKEI QQFLQSDKIH 70 80 90 100 110 120 FNATLDKNEA YRDADYVIIA TPTDYDPKTN YFNTSSVESV IKDVVEINPY AVMVIKSTVP 130 140 150 160 170 180 VGFTAAMHKK YRTENIIFSP EFLREGKALY DNLHPSRIVI GERSERAERF AALLQEGAIK 190 200 210 220 230 240 QNIPTLFTDS TEAEAIKLFA NTYLAMRVAY FNELDSYAES LGLNTRQIIE GVCLDPRIGN 250 260 270 280 290 300 HYNNPSFGYG GYCLPKDTKQ LLANYQSVPN NLISAIVDAN RKWWVFIVIM KSGSDNFRAS 310 320 330 340 350 360 SIQGIMKRIK AKGVEVIIYE PVMKGDSFFN SRLERDLATF KQQADVIISN RMAEELKDVA 370 DKVYTRDLFG SD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the rfc region of Shigella flexneri." Morona R., Mavris M., Fallarino A., Manning P.A. J. Bacteriol. 176:733-747(1994) [PubMed: 7507920] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: PE577 / Serotype 2a.
[2]	"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157." Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J. Nucleic Acids Res. 30:4432-4441(2002) [PubMed: 12384590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 301 / Serotype 2a.
[3]	"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T." Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R. Infect. Immun. 71:2775-2786(2003) [PubMed: 12704152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700930 / 2457T / Serotype 2a.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X71970 Genomic DNA. Translation: CAA50782.1. AE005674 Genomic DNA. No translation available. AE014073 Genomic DNA. No translation available.
3D structure databases
HSSP	HSSP built from PDB template 1DLJ based on UniProtKB Q07172.
ModBase	Search...
Genome annotation databases
GenomeReviews	Gene locus S2211 in contig AE014073_GR.
KEGG	sfx:S2211.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P37791.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DHase_C. IPR014026. UDP-Glc/GDP-Man_DHase_dimer. IPR014028. UDP-Glc/GDP-Man_DHase_dimer-bd. IPR001732. UDP-Glc/GDP-Man_DHase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:3.40.50.1870. UDP-Glc/GDP-Man_DH_C. 1 hit.
PANTHER	PTHR11374. UDPG_MGDP_DH_Creg. 1 hit.
Pfam	PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UDG_SHIFL

Accession

Primary (citable) accession number: P37791

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	November 25, 2008
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)