ID GALF_SHIFL Reviewed; 297 AA. AC P37776; Q54161; DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot. DT 10-JAN-2003, sequence version 2. DT 27-MAR-2024, entry version 140. DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase; DE EC=2.7.7.9; DE AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase; DE AltName: Full=UDP-glucose pyrophosphorylase; DE Short=UDPGP; DE AltName: Full=Uridine diphosphoglucose pyrophosphorylase; GN Name=galF; OrderedLocusNames=SF2105, S2228; OS Shigella flexneri. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Shigella. OX NCBI_TaxID=623; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=PE577 / Serotype 2a; RX PubMed=8170390; DOI=10.1111/j.1365-2958.1994.tb00308.x; RA Macpherson D.F., Manning P.A., Morona R.; RT "Characterization of the dTDP-rhamnose biosynthetic genes encoded in the RT rfb locus of Shigella flexneri."; RL Mol. Microbiol. 11:281-292(1994). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=301 / Serotype 2a; RX PubMed=12384590; DOI=10.1093/nar/gkf566; RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.; RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity RT through comparison with genomes of Escherichia coli K12 and O157."; RL Nucleic Acids Res. 30:4432-4441(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700930 / 2457T / Serotype 2a; RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003; RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.; RT "Complete genome sequence and comparative genomics of Shigella flexneri RT serotype 2a strain 2457T."; RL Infect. Immun. 71:2775-2786(2003). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 169-297. RC STRAIN=YSH6200 / Serotype 2a; RX PubMed=8157605; DOI=10.1128/jb.176.8.2362-2373.1994; RA Rajakumar K., Jost B.H., Sasakawa C., Okada N., Yoshikawa M., Adler B.; RT "Nucleotide sequence of the rhamnose biosynthetic operon of Shigella RT flexneri 2a and role of lipopolysaccharide in virulence."; RL J. Bacteriol. 176:2362-2373(1994). CC -!- CATALYTIC ACTIVITY: CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP- CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601, CC ChEBI:CHEBI:58885; EC=2.7.7.9; CC -!- PATHWAY: Carbohydrate metabolism; nucleotide-sugar metabolism. CC -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide CC biosynthesis. CC -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X71970; CAA50766.1; -; Genomic_DNA. DR EMBL; AE005674; AAN43644.2; -; Genomic_DNA. DR EMBL; AE014073; AAP17473.1; -; Genomic_DNA. DR EMBL; L14842; AAA53678.1; -; Genomic_DNA. DR PIR; S41533; S41533. DR RefSeq; NP_707937.2; NC_004337.2. DR RefSeq; WP_000183041.1; NZ_WPGW01000076.1. DR AlphaFoldDB; P37776; -. DR SMR; P37776; -. DR STRING; 198214.SF2105; -. DR PaxDb; 198214-SF2105; -. DR GeneID; 1025313; -. DR KEGG; sfl:SF2105; -. DR KEGG; sfx:S2228; -. DR PATRIC; fig|198214.7.peg.2513; -. DR HOGENOM; CLU_029499_1_2_6; -. DR UniPathway; UPA00030; -. DR UniPathway; UPA00215; -. DR Proteomes; UP000001006; Chromosome. DR Proteomes; UP000002673; Chromosome. DR GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro. DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro. DR CDD; cd02541; UGPase_prokaryotic; 1. DR InterPro; IPR005774; GalF. DR InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc. DR InterPro; IPR005835; NTP_transferase_dom. DR InterPro; IPR029044; Nucleotide-diphossugar_trans. DR NCBIfam; TIGR01105; galF; 1. DR PANTHER; PTHR43197; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1. DR PANTHER; PTHR43197:SF2; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1. DR Pfam; PF00483; NTP_transferase; 1. DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1. PE 3: Inferred from homology; KW Lipopolysaccharide biosynthesis; Nucleotidyltransferase; KW Reference proteome; Transferase. FT CHAIN 1..297 FT /note="UTP--glucose-1-phosphate uridylyltransferase" FT /id="PRO_0000201353" FT CONFLICT 31..32 FT /note="IV -> TA (in Ref. 1; CAA50766)" FT /evidence="ECO:0000305" FT CONFLICT 285 FT /note="A -> S (in Ref. 1; CAA50766)" FT /evidence="ECO:0000305" SQ SEQUENCE 297 AA; 32841 MW; D693305ECBD9DF8A CRC64; MTNLKAVIPV AGLGMHMLPA TKAIPKEMLP IVDKPMIQYI VDEIVAAGIK EILLVTHASK NAVENHFDTS YELESLLEQR VKRQLLAEVQ SICPPGVIIM NVRQGEPLGL GHSILCARPA IGDNPFVVVL PDVVIDDASA DPLRYNLAAM IARFNETGRS QVLAKRMPGD LSEYSVIQTK EPLDREGKVS RIVEFIEKPD QPQTLDSDIM AVGRYVLSAD IWPELERTQP GAWGRIQLTD AIAELAKKQS VDAMLMTGDS YDCGKKMGYM QAFVKYGLRN LKEGAKFRKG IEKLLSE //