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P37776

- GALF_SHIFL

UniProt

P37776 - GALF_SHIFL

Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

galF

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (10 Jan 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

    Pathwayi

    GO - Molecular functioni

    1. enzyme regulator activity Source: InterPro
    2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
    2. UDP-glucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00030.
    UPA00215.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
    Alternative name(s):
    Alpha-D-glucosyl-1-phosphate uridylyltransferase
    UDP-glucose pyrophosphorylase
    Short name:
    UDPGP
    Uridine diphosphoglucose pyrophosphorylase
    Gene namesi
    Name:galF
    Ordered Locus Names:SF2105, S2228
    OrganismiShigella flexneri
    Taxonomic identifieri623 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297UTP--glucose-1-phosphate uridylyltransferasePRO_0000201353Add
    BLAST

    Proteomic databases

    PaxDbiP37776.
    PRIDEiP37776.

    Interactioni

    Protein-protein interaction databases

    STRINGi198214.SF2105.

    Structurei

    3D structure databases

    ProteinModelPortaliP37776.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDPGP type 2 family.Curated

    Phylogenomic databases

    eggNOGiCOG1210.
    HOGENOMiHOG000283477.
    KOiK00963.
    OrthoDBiEOG6Z9B3V.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR005774. GalF.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR01105. galF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P37776-1 [UniParc]FASTAAdd to Basket

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    MTNLKAVIPV AGLGMHMLPA TKAIPKEMLP IVDKPMIQYI VDEIVAAGIK    50
    EILLVTHASK NAVENHFDTS YELESLLEQR VKRQLLAEVQ SICPPGVIIM 100
    NVRQGEPLGL GHSILCARPA IGDNPFVVVL PDVVIDDASA DPLRYNLAAM 150
    IARFNETGRS QVLAKRMPGD LSEYSVIQTK EPLDREGKVS RIVEFIEKPD 200
    QPQTLDSDIM AVGRYVLSAD IWPELERTQP GAWGRIQLTD AIAELAKKQS 250
    VDAMLMTGDS YDCGKKMGYM QAFVKYGLRN LKEGAKFRKG IEKLLSE 297
    Length:297
    Mass (Da):32,841
    Last modified:January 10, 2003 - v2
    Checksum:iD693305ECBD9DF8A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 322IV → TA in CAA50766. (PubMed:8170390)Curated
    Sequence conflicti285 – 2851A → S in CAA50766. (PubMed:8170390)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71970 Genomic DNA. Translation: CAA50766.1.
    AE005674 Genomic DNA. Translation: AAN43644.2.
    AE014073 Genomic DNA. Translation: AAP17473.1.
    L14842 Genomic DNA. Translation: AAA53678.1.
    PIRiS41533.
    RefSeqiNP_707937.2. NC_004337.2.
    NP_837664.1. NC_004741.1.

    Genome annotation databases

    EnsemblBacteriaiAAN43644; AAN43644; SF2105.
    AAP17473; AAP17473; S2228.
    GeneIDi1025313.
    1078506.
    KEGGisfl:SF2105.
    sfx:S2228.
    PATRICi18705963. VBIShiFle31049_2460.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71970 Genomic DNA. Translation: CAA50766.1 .
    AE005674 Genomic DNA. Translation: AAN43644.2 .
    AE014073 Genomic DNA. Translation: AAP17473.1 .
    L14842 Genomic DNA. Translation: AAA53678.1 .
    PIRi S41533.
    RefSeqi NP_707937.2. NC_004337.2.
    NP_837664.1. NC_004741.1.

    3D structure databases

    ProteinModelPortali P37776.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198214.SF2105.

    Proteomic databases

    PaxDbi P37776.
    PRIDEi P37776.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN43644 ; AAN43644 ; SF2105 .
    AAP17473 ; AAP17473 ; S2228 .
    GeneIDi 1025313.
    1078506.
    KEGGi sfl:SF2105.
    sfx:S2228.
    PATRICi 18705963. VBIShiFle31049_2460.

    Phylogenomic databases

    eggNOGi COG1210.
    HOGENOMi HOG000283477.
    KOi K00963.
    OrthoDBi EOG6Z9B3V.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00215 .

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR005774. GalF.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR01105. galF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the dTDP-rhamnose biosynthetic genes encoded in the rfb locus of Shigella flexneri."
      Macpherson D.F., Manning P.A., Morona R.
      Mol. Microbiol. 11:281-292(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: PE577 / Serotype 2a.
    2. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
      Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
      , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
      Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 301 / Serotype 2a.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700930 / 2457T / Serotype 2a.
    4. "Nucleotide sequence of the rhamnose biosynthetic operon of Shigella flexneri 2a and role of lipopolysaccharide in virulence."
      Rajakumar K., Jost B.H., Sasakawa C., Okada N., Yoshikawa M., Adler B.
      J. Bacteriol. 176:2362-2373(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 169-297.
      Strain: YSH6200 / Serotype 2a.

    Entry informationi

    Entry nameiGALF_SHIFL
    AccessioniPrimary (citable) accession number: P37776
    Secondary accession number(s): Q54161
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: January 10, 2003
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3