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P37776

- GALF_SHIFL

UniProt

P37776 - GALF_SHIFL

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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

galF

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi

GO - Molecular functioni

  1. enzyme regulator activity Source: InterPro
  2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
  2. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00215.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:galF
Ordered Locus Names:SF2105, S2228
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297UTP--glucose-1-phosphate uridylyltransferasePRO_0000201353Add
BLAST

Proteomic databases

PaxDbiP37776.
PRIDEiP37776.

Interactioni

Protein-protein interaction databases

STRINGi198214.SF2105.

Structurei

3D structure databases

ProteinModelPortaliP37776.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OrthoDBiEOG6Z9B3V.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005774. GalF.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01105. galF. 1 hit.

Sequencei

Sequence statusi: Complete.

P37776-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNLKAVIPV AGLGMHMLPA TKAIPKEMLP IVDKPMIQYI VDEIVAAGIK
60 70 80 90 100
EILLVTHASK NAVENHFDTS YELESLLEQR VKRQLLAEVQ SICPPGVIIM
110 120 130 140 150
NVRQGEPLGL GHSILCARPA IGDNPFVVVL PDVVIDDASA DPLRYNLAAM
160 170 180 190 200
IARFNETGRS QVLAKRMPGD LSEYSVIQTK EPLDREGKVS RIVEFIEKPD
210 220 230 240 250
QPQTLDSDIM AVGRYVLSAD IWPELERTQP GAWGRIQLTD AIAELAKKQS
260 270 280 290
VDAMLMTGDS YDCGKKMGYM QAFVKYGLRN LKEGAKFRKG IEKLLSE
Length:297
Mass (Da):32,841
Last modified:January 10, 2003 - v2
Checksum:iD693305ECBD9DF8A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 322IV → TA in CAA50766. (PubMed:8170390)Curated
Sequence conflicti285 – 2851A → S in CAA50766. (PubMed:8170390)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71970 Genomic DNA. Translation: CAA50766.1.
AE005674 Genomic DNA. Translation: AAN43644.2.
AE014073 Genomic DNA. Translation: AAP17473.1.
L14842 Genomic DNA. Translation: AAA53678.1.
PIRiS41533.
RefSeqiNP_707937.2. NC_004337.2.
NP_837664.1. NC_004741.1.
WP_000183041.1. NZ_JMRK01000046.1.

Genome annotation databases

EnsemblBacteriaiAAN43644; AAN43644; SF2105.
AAP17473; AAP17473; S2228.
GeneIDi1025313.
1078506.
KEGGisfl:SF2105.
sfx:S2228.
PATRICi18705963. VBIShiFle31049_2460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71970 Genomic DNA. Translation: CAA50766.1 .
AE005674 Genomic DNA. Translation: AAN43644.2 .
AE014073 Genomic DNA. Translation: AAP17473.1 .
L14842 Genomic DNA. Translation: AAA53678.1 .
PIRi S41533.
RefSeqi NP_707937.2. NC_004337.2.
NP_837664.1. NC_004741.1.
WP_000183041.1. NZ_JMRK01000046.1.

3D structure databases

ProteinModelPortali P37776.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198214.SF2105.

Proteomic databases

PaxDbi P37776.
PRIDEi P37776.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN43644 ; AAN43644 ; SF2105 .
AAP17473 ; AAP17473 ; S2228 .
GeneIDi 1025313.
1078506.
KEGGi sfl:SF2105.
sfx:S2228.
PATRICi 18705963. VBIShiFle31049_2460.

Phylogenomic databases

eggNOGi COG1210.
HOGENOMi HOG000283477.
KOi K00963.
OrthoDBi EOG6Z9B3V.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00215 .

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR005774. GalF.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF00483. NTP_transferase. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR01105. galF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the dTDP-rhamnose biosynthetic genes encoded in the rfb locus of Shigella flexneri."
    Macpherson D.F., Manning P.A., Morona R.
    Mol. Microbiol. 11:281-292(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PE577 / Serotype 2a.
  2. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.
  4. "Nucleotide sequence of the rhamnose biosynthetic operon of Shigella flexneri 2a and role of lipopolysaccharide in virulence."
    Rajakumar K., Jost B.H., Sasakawa C., Okada N., Yoshikawa M., Adler B.
    J. Bacteriol. 176:2362-2373(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 169-297.
    Strain: YSH6200 / Serotype 2a.

Entry informationi

Entry nameiGALF_SHIFL
AccessioniPrimary (citable) accession number: P37776
Secondary accession number(s): Q54161
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 10, 2003
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3