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P37776 (GALF_SHIFL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UTP--glucose-1-phosphate uridylyltransferase

EC=2.7.7.9
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name=UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene names
Name:galF
Ordered Locus Names:SF2105, S2228
OrganismShigella flexneri [Complete proteome] [HAMAP]
Taxonomic identifier623 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathway

Carbohydrate metabolism; nucleotide-sugar metabolism.

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.

Sequence similarities

Belongs to the UDPGP type 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297UTP--glucose-1-phosphate uridylyltransferase
PRO_0000201353

Experimental info

Sequence conflict31 – 322IV → TA in CAA50766. Ref.1
Sequence conflict2851A → S in CAA50766. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P37776 [UniParc].

Last modified January 10, 2003. Version 2.
Checksum: D693305ECBD9DF8A

FASTA29732,841
        10         20         30         40         50         60 
MTNLKAVIPV AGLGMHMLPA TKAIPKEMLP IVDKPMIQYI VDEIVAAGIK EILLVTHASK 

        70         80         90        100        110        120 
NAVENHFDTS YELESLLEQR VKRQLLAEVQ SICPPGVIIM NVRQGEPLGL GHSILCARPA 

       130        140        150        160        170        180 
IGDNPFVVVL PDVVIDDASA DPLRYNLAAM IARFNETGRS QVLAKRMPGD LSEYSVIQTK 

       190        200        210        220        230        240 
EPLDREGKVS RIVEFIEKPD QPQTLDSDIM AVGRYVLSAD IWPELERTQP GAWGRIQLTD 

       250        260        270        280        290 
AIAELAKKQS VDAMLMTGDS YDCGKKMGYM QAFVKYGLRN LKEGAKFRKG IEKLLSE 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the dTDP-rhamnose biosynthetic genes encoded in the rfb locus of Shigella flexneri."
Macpherson D.F., Manning P.A., Morona R.
Mol. Microbiol. 11:281-292(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: PE577 / Serotype 2a.
[2]"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. expand/collapse author list , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 301 / Serotype 2a.
[3]"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T."
Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.
Infect. Immun. 71:2775-2786(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700930 / 2457T / Serotype 2a.
[4]"Nucleotide sequence of the rhamnose biosynthetic operon of Shigella flexneri 2a and role of lipopolysaccharide in virulence."
Rajakumar K., Jost B.H., Sasakawa C., Okada N., Yoshikawa M., Adler B.
J. Bacteriol. 176:2362-2373(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 169-297.
Strain: YSH6200 / Serotype 2a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X71970 Genomic DNA. Translation: CAA50766.1.
AE005674 Genomic DNA. Translation: AAN43644.2.
AE014073 Genomic DNA. Translation: AAP17473.1.
L14842 Genomic DNA. Translation: AAA53678.1.
PIRS41533.
RefSeqNP_707937.2. NC_004337.2.
NP_837664.1. NC_004741.1.

3D structure databases

ProteinModelPortalP37776.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198214.SF2105.

Proteomic databases

PaxDbP37776.
PRIDEP37776.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN43644; AAN43644; SF2105.
AAP17473; AAP17473; S2228.
GeneID1025313.
1078506.
KEGGsfl:SF2105.
sfx:S2228.
PATRIC18705963. VBIShiFle31049_2460.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1210.
HOGENOMHOG000283477.
KOK00963.
OrthoDBEOG6Z9B3V.
ProtClustDBPRK10122.

Enzyme and pathway databases

UniPathwayUPA00030.
UPA00215.

Family and domain databases

InterProIPR005774. GalF.
IPR005835. NTP_transferase.
[Graphical view]
PfamPF00483. NTP_transferase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01105. galF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGALF_SHIFL
AccessionPrimary (citable) accession number: P37776
Secondary accession number(s): Q54161
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 10, 2003
Last modified: April 16, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways