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Protein

L-cystine transport system ATP-binding protein YecC

Gene

yecC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. The system can probably also transport L-cysteine, and it mediates accumulation of the toxic compounds L-selenaproline (SCA) and L-selenocystine (SeCys) (PubMed:25139244). Probably responsible for energy coupling to the transport system (Probable).Curated1 Publication

Enzyme regulationi

The FliY-YecC-YecS system is inhibited by L-cystine, L-cysteine, DL-2,6-diaminopimelic acid and L-cystathionine, and is stimulated by D-cysteine.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 438ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • amino acid-transporting ATPase activity Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • cysteine transmembrane transporter activity Source: EcoCyc
  • L-cystine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • cysteine transport Source: EcoCyc
  • L-cystine transport Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12347-MONOMER.
ECOL316407:JW1902-MONOMER.
RETL1328306-WGS:GSTH-5495-MONOMER.

Protein family/group databases

TCDBi3.A.1.3.10. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
L-cystine transport system ATP-binding protein YecCCurated (EC:3.6.3.-Curated)
Gene namesi
Name:yecC
Ordered Locus Names:b1917, JW1902
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12347. yecC.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250L-cystine transport system ATP-binding protein YecCPRO_0000093166Add
BLAST

Proteomic databases

PaxDbiP37774.
PRIDEiP37774.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (YecC), two transmembrane proteins (YecS) and a solute-binding protein (FliY).Curated

Protein-protein interaction databases

BioGridi4260366. 5 interactions.
DIPiDIP-11822N.
IntActiP37774. 5 interactions.
MINTiMINT-1262709.
STRINGi511145.b1917.

Structurei

3D structure databases

ProteinModelPortaliP37774.
SMRiP37774. Positions 4-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 244241ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CDA. Bacteria.
COG1126. LUCA.
InParanoidiP37774.
KOiK10010.
OMAiLFADPKQ.
OrthoDBiEOG6T7N3V.
PhylomeDBiP37774.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR030679. ABC_ATPase_HisP-typ.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF039085. ABC_ATPase_HisP. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAIEVKNLV KKFHGQTVLH GIDLEVKPGE VVAIIGPSGS GKTTLLRSIN
60 70 80 90 100
LLEQPEAGTI TVGDITIDTA RSLSQQKSLI RQLRQHVGFV FQNFNLFPHR
110 120 130 140 150
TVLENIIEGP VIVKGEPKEE ATARARELLA KVGLAGKETS YPRRLSGGQQ
160 170 180 190 200
QRVAIARALA MRPEVILFDE PTSALDPELV GEVLNTIRQL AQEKRTMVIV
210 220 230 240 250
THEMSFARDV ADRAIFMDQG RIVEQGAAKA LFADPEQPRT RQFLEKFLLQ
Length:250
Mass (Da):27,677
Last modified:November 1, 1997 - v2
Checksum:iF05E07F160121C60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74984.1.
AP009048 Genomic DNA. Translation: BAA15737.1.
X03691 Genomic DNA. No translation available.
PIRiB64955.
RefSeqiNP_416427.1. NC_000913.3.
WP_001272991.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74984; AAC74984; b1917.
BAA15737; BAA15737; BAA15737.
GeneIDi946422.
KEGGiecj:JW1902.
eco:b1917.
PATRICi32119169. VBIEscCol129921_1999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74984.1.
AP009048 Genomic DNA. Translation: BAA15737.1.
X03691 Genomic DNA. No translation available.
PIRiB64955.
RefSeqiNP_416427.1. NC_000913.3.
WP_001272991.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37774.
SMRiP37774. Positions 4-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260366. 5 interactions.
DIPiDIP-11822N.
IntActiP37774. 5 interactions.
MINTiMINT-1262709.
STRINGi511145.b1917.

Protein family/group databases

TCDBi3.A.1.3.10. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP37774.
PRIDEiP37774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74984; AAC74984; b1917.
BAA15737; BAA15737; BAA15737.
GeneIDi946422.
KEGGiecj:JW1902.
eco:b1917.
PATRICi32119169. VBIEscCol129921_1999.

Organism-specific databases

EchoBASEiEB2251.
EcoGeneiEG12347. yecC.

Phylogenomic databases

eggNOGiENOG4105CDA. Bacteria.
COG1126. LUCA.
InParanoidiP37774.
KOiK10010.
OMAiLFADPKQ.
OrthoDBiEOG6T7N3V.
PhylomeDBiP37774.

Enzyme and pathway databases

BioCyciEcoCyc:EG12347-MONOMER.
ECOL316407:JW1902-MONOMER.
RETL1328306-WGS:GSTH-5495-MONOMER.

Miscellaneous databases

PROiP37774.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR030679. ABC_ATPase_HisP-typ.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF039085. ABC_ATPase_HisP. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Multiple control elements for the uvrC gene unit of Escherichia coli."
    Sharma S., Stark T.F., Beattie W.G., Moses R.E.
    Nucleic Acids Res. 14:2301-2318(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 176-250.
  5. "Intrinsic and extrinsic approaches for detecting genes in a bacterial genome."
    Borodovsky M., Rudd K.E., Koonin E.V.
    Nucleic Acids Res. 22:4756-4767(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. "Susceptibility of Escherichia coli to the toxic L-proline analogue L-selenaproline is dependent on two L-cystine transport systems."
    Deutch C.E., Spahija I., Wagner C.E.
    J. Appl. Microbiol. 117:1487-1499(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION.
    Strain: K12.

Entry informationi

Entry nameiYECC_ECOLI
AccessioniPrimary (citable) accession number: P37774
Secondary accession number(s): P76314
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.