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Protein

Acetate CoA-transferase YdiF

Gene

ydiF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. May play a role in short-chain fatty acid metabolism in E.coli (By similarity).By similarity

Miscellaneous

Formation of the covalent enzyme-CoA thioester intermediate proceeds via an unstable anhydride species formed between the carboxylate group of the catalytic glutamate of the enzyme and the carbonyl carbon of the thioester linkage of the substrate.By similarity

Catalytic activityi

Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3335-glutamyl coenzyme A thioester intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciEcoCyc:EG12432-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate CoA-transferase YdiF (EC:2.8.3.8)
Alternative name(s):
Short-chain acyl-CoA:acetate CoA-transferase
Gene namesi
Name:ydiF
Ordered Locus Names:b1694, JW1684
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12432 ydiF

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001689901 – 531Acetate CoA-transferase YdiFAdd BLAST531

Proteomic databases

PaxDbiP37766
PRIDEiP37766

Interactioni

Subunit structurei

Homotetramer; dimer of dimers.By similarity

Protein-protein interaction databases

BioGridi4260290, 22 interactors
IntActiP37766, 2 interactors
STRINGi316407.85675080

Structurei

3D structure databases

ProteinModelPortaliP37766
SMRiP37766
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-oxoacid CoA-transferase family.Curated

Phylogenomic databases

eggNOGiENOG4107R0K Bacteria
COG4670 LUCA
HOGENOMiHOG000058376
InParanoidiP37766
KOiK19709
OMAiNPAYSGE
PhylomeDBiP37766

Family and domain databases

InterProiView protein in InterPro
IPR014388 3-oxoacid_CoA-transferase
IPR004165 CoA_trans_fam_I
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01144 CoA_trans, 1 hit
PIRSFiPIRSF000858 SCOT-t, 1 hit
SMARTiView protein in SMART
SM00882 CoA_trans, 1 hit
SUPFAMiSSF100950 SSF100950, 2 hits

Sequencei

Sequence statusi: Complete.

P37766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPVKPPRIN GRVPVLSAQE AVNYIPDEAT LCVLGAGGGI LEATTLITAL
60 70 80 90 100
ADKYKQTQTP RNLSIISPTG LGDRADRGIS PLAQEGLVKW ALCGHWGQSP
110 120 130 140 150
RISELAEQNK IIAYNYPQGV LTQTLRAAAA HQPGIISDIG IGTFVDPRQQ
160 170 180 190 200
GGKLNEVTKE DLIKLVEFDN KEYLYYKAIA PDIAFIRATT CDSEGYATFE
210 220 230 240 250
DEVMYLDALV IAQAVHNNGG IVMMQVQKMV KKATLHPKSV RIPGYLVDIV
260 270 280 290 300
VVDPDQTQLY GGAPVNRFIS GDFTLDDSTK LSLPLNQRKL VARRALFEMR
310 320 330 340 350
KGAVGNVGVG IADGIGLVAR EEGCADDFIL TVETGPIGGI TSQGIAFGAN
360 370 380 390 400
VNTRAILDMT SQFDFYHGGG LDVCYLSFAE VDQHGNVGVH KFNGKIMGTG
410 420 430 440 450
GFIDISATSK KIIFCGTLTA GSLKTEITDG KLNIVQEGRV KKFIRELPEI
460 470 480 490 500
TFSGKIALER GLDVRYITER AVFTLKEDGL HLIEIAPGVD LQKDILDKMD
510 520 530
FTPVISPELK LMDERLFIDA AMGFVLPEAA H
Length:531
Mass (Da):57,562
Last modified:December 1, 2000 - v3
Checksum:iE07A0D445015030D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74764.1
AP009048 Genomic DNA Translation: BAA15447.2
X04306 Genomic DNA No translation available.
PIRiF64927
RefSeqiNP_416209.1, NC_000913.3
WP_000805700.1, NZ_CP011343.2

Genome annotation databases

EnsemblBacteriaiAAC74764; AAC74764; b1694
BAA15447; BAA15447; BAA15447
GeneIDi946211
KEGGiecj:JW1684
eco:b1694
PATRICifig|1411691.4.peg.564

Similar proteinsi

Entry informationi

Entry nameiYDIF_ECOLI
AccessioniPrimary (citable) accession number: P37766
Secondary accession number(s): P76199, P76898
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: December 1, 2000
Last modified: March 28, 2018
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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