Reviewed,
UniProtKB/Swiss-Prot P37765 (RLUB_ECOLI)
Last modified
June 16, 2009.
Version 75.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Ribosomal large subunit pseudouridine synthase B EC=5.4.99.- Alternative name(s): rRNA-uridine isomerase B rRNA pseudouridylate synthase B | ||||||
| Gene names |
| ||||||
| Organism | Escherichia coli (strain K12) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 83333 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 291 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA. Ref.7 |
| Catalytic activity | rRNA uridine = rRNA pseudouridine. |
| Sequence similarities | Belongs to the pseudouridine synthase rsuA family. Contains 1 S4 RNA-binding domain. |
| Sequence caution | The sequence M21528 differs from that shown. Reason: Frameshift at position 228. |
Ontologies
| Keywords | |
|---|---|
| Biological process | rRNA processing |
| Ligand | RNA-binding |
| Molecular function | Isomerase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | pseudouridine synthesis Inferred from electronic annotation. Source: InterPro rRNA processingInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | RNA binding Inferred from electronic annotation. Source: UniProtKB-KW pseudouridine synthase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map." Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T., Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K. Horiuchi T.DNA Res. 3:363-377(1996) [PubMed: 9097039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
| [2] | "The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076. |
| [3] | "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
| [4] | Milkman R., McKane M. Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-243. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
| [5] | "Altered cobalamin metabolism in Escherichia coli btuR mutants affects btuB gene regulation." Lundrigan M.D., Kadner R.J. J. Bacteriol. 171:154-161(1989) [PubMed: 2644187] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 217-291. Strain: K12. |
| [6] | "Intrinsic and extrinsic approaches for detecting genes in a bacterial genome." Borodovsky M., Rudd K.E., Koonin E.V. Nucleic Acids Res. 22:4756-4767(1994) [PubMed: 7984428] [Abstract] Cited for: IDENTIFICATION. |
| [7] | "Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli." Del Campo M., Kaya Y., Ofengand J. RNA 7:1603-1615(2001) [PubMed: 11720289] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF ASP-110. Strain: K12 / MG1655 / ATCC 47076. |
Cross-references
Sequence databases | |
|---|---|
| U00096 Genomic DNA. Translation: AAC74351.1. AP009048 Genomic DNA. Translation: BAA14806.1. U18111 Genomic DNA. Translation: AAB59990.1. M21528 Genomic DNA. No translation available. | |
| PIR | H64874. |
| RefSeq | AP_001895.1. NP_415785.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1KSK based on UniProtKB P33918. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:11585N. |
Genome annotation databases | |
| GeneID | 945840. |
| GenomeReviews | Gene locus JW1261 in contig AP009048_GR. Gene locus b1269 in contig U00096_GR. |
| KEGG | ecj:JW1261. eco:b1269. |
Organism-specific databases | |
| EchoBASE | EB2329. |
| EcoGene | EG12433. rluB. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P37765. |
| OMA | P37765. GELCTRS. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:EG12433-MON. |
Family and domain databases | |
| InterPro | IPR006145. Pseudouridine_synth. IPR000748. rRNA_pseudouridine_synth. IPR018496. rRNA_pseudouridine_synth_CS. IPR002942. S4_RNA_bd. [Graphical view] |
| Pfam | PF00849. PseudoU_synth_2. 1 hit. PF01479. S4. 1 hit. [Graphical view] |
| SMART | SM00363. S4. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00093. Psi__synth_RSU. 1 hit. |
| PROSITE | PS01149. PSI_RSU. 1 hit. PS50889. S4. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RLUB_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P37765 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| SIMILARITY comments Index of protein domains and families |

Clusters with


