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P37763

- RMLC_NEIGO

UniProt

P37763 - RMLC_NEIGO

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Protein
dTDP-4-dehydrorhamnose 3,5-epimerase
Gene
rfbC, rmlC
Organism
Neisseria gonorrhoeae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose By similarity.

Catalytic activityi

dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei23 – 231Substrate By similarity
Binding sitei28 – 281Substrate By similarity
Binding sitei46 – 461Substrate By similarity
Binding sitei48 – 481Substrate By similarity
Binding sitei58 – 581Substrate By similarity
Binding sitei61 – 611Substrate By similarity
Sitei61 – 611Important in abstrating the protons in C3' and C5' By similarity
Binding sitei70 – 701Substrate By similarity
Binding sitei81 – 811Substrate By similarity
Binding sitei117 – 1171Substrate By similarity
Sitei130 – 1301May have a key role in proton donation to C5' By similarity

GO - Molecular functioni

  1. dTDP-4-dehydrorhamnose 3,5-epimerase activity Source: UniProtKB

GO - Biological processi

  1. O antigen biosynthetic process Source: UniProtKB-UniPathway
  2. dTDP-rhamnose biosynthetic process Source: UniProtKB-UniPathway
  3. extracellular polysaccharide biosynthetic process Source: UniProtKB
  4. lipopolysaccharide biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00124.
UPA00281.

Names & Taxonomyi

Protein namesi
Recommended name:
dTDP-4-dehydrorhamnose 3,5-epimerase (EC:5.1.3.13)
Alternative name(s):
Thymidine diphospho-4-keto-rhamnose 3,5-epimerase
dTDP-4-keto-6-deoxyglucose 3,5-epimerase
dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase
dTDP-L-rhamnose synthase
Gene namesi
Name:rfbC
Synonyms:rmlC
OrganismiNeisseria gonorrhoeae
Taxonomic identifieri485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328dTDP-4-dehydrorhamnose 3,5-epimerase
PRO_0000207981Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP37763.
SMRiP37763. Positions 1-178.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 1672Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR000888. dTDP_sugar_isom.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR21047. PTHR21047. 1 hit.
PfamiPF00908. dTDP_sugar_isom. 1 hit.
[Graphical view]
ProDomiPD001462. dTDP_sugar_isom. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01221. rmlC. 1 hit.

Sequencei

Sequence statusi: Complete.

P37763-1 [UniParc]FASTAAdd to Basket

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MDIIDTALPD VKLLKPQVFT DGRGFFMETF RDGWFKENIA DRTFVQENHS    50
NSSKGVLRGL HYQTENTQGK LVRVVVGEVF DVAVDMREGS PTFGKWAGAT 100
LSAQNRYQLW IPEGFAHGFC VLGDAAEVVY KCTDYYNPET EQVLIWNDPA 150
IGIGWPLQTA PLLSPKDLAG KTWAQAEKSA LRFPDKKCRP NVSDGIFSDR 200
LPTRLQYALC KEKHPGNEER QAQPRSGGIP VLQIQRERRI RAAVGHREGN 250
NKRHNYTNQA FTDNQACREK RTDTVGVFQT AFAVFRLLAN DVFQHRRQHR 300
ACHDGHIDGR RQINAHTDRK DGQGKFTA 328
Length:328
Mass (Da):37,209
Last modified:October 1, 1994 - v1
Checksum:i20BA7BA065604D4F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z32742 Genomic DNA. Translation: CAA83654.1.
Z21508 Genomic DNA. Translation: CAA79720.1.
PIRiS47047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z32742 Genomic DNA. Translation: CAA83654.1 .
Z21508 Genomic DNA. Translation: CAA79720.1 .
PIRi S47047.

3D structure databases

ProteinModelPortali P37763.
SMRi P37763. Positions 1-178.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00124 .
UPA00281 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR000888. dTDP_sugar_isom.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR21047. PTHR21047. 1 hit.
Pfami PF00908. dTDP_sugar_isom. 1 hit.
[Graphical view ]
ProDomi PD001462. dTDP_sugar_isom. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01221. rmlC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The identification of cryptic rhamnose biosynthesis genes in Neisseria gonorrhoeae and their relationship to lipopolysaccharide biosynthesis."
    Robertson B.D., Frosch M., van Putten J.P.M.
    J. Bacteriol. 176:6915-6920(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MS11.
  2. "Genes associated with meningococcal capsule complex are also found in Neisseria gonorrhoeae."
    Petering H., Hammerschmidt S., Frosch M., van Putten J.P.M., Ison C.A., Robertson B.D.
    J. Bacteriol. 178:3342-3345(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MS11.

Entry informationi

Entry nameiRMLC_NEIGO
AccessioniPrimary (citable) accession number: P37763
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: December 11, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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