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Protein

dTDP-4-dehydrorhamnose 3,5-epimerase

Gene

rfbC

Organism
Neisseria gonorrhoeae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.By similarity

Catalytic activityi

dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose.

Pathwayi: dTDP-L-rhamnose biosynthesis

This protein is involved in the pathway dTDP-L-rhamnose biosynthesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway dTDP-L-rhamnose biosynthesis and in Carbohydrate biosynthesis.

Pathwayi: LPS O-antigen biosynthesis

This protein is involved in the pathway LPS O-antigen biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway LPS O-antigen biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei23SubstrateBy similarity1
Binding sitei28SubstrateBy similarity1
Binding sitei46SubstrateBy similarity1
Binding sitei48SubstrateBy similarity1
Binding sitei58SubstrateBy similarity1
Binding sitei61SubstrateBy similarity1
Sitei61Important in abstrating the protons in C3' and C5'By similarity1
Binding sitei70SubstrateBy similarity1
Binding sitei81SubstrateBy similarity1
Binding sitei117SubstrateBy similarity1
Sitei130May have a key role in proton donation to C5'By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00124.
UPA00281.

Names & Taxonomyi

Protein namesi
Recommended name:
dTDP-4-dehydrorhamnose 3,5-epimerase (EC:5.1.3.13)
Alternative name(s):
Thymidine diphospho-4-keto-rhamnose 3,5-epimerase
dTDP-4-keto-6-deoxyglucose 3,5-epimerase
dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase
dTDP-L-rhamnose synthase
Gene namesi
Name:rfbC
Synonyms:rmlC
OrganismiNeisseria gonorrhoeae
Taxonomic identifieri485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002079811 – 328dTDP-4-dehydrorhamnose 3,5-epimeraseAdd BLAST328

Interactioni

Protein-protein interaction databases

STRINGi528357.NgonPI_010100010760.

Structurei

3D structure databases

ProteinModelPortaliP37763.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 167Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108URP. Bacteria.
COG1898. LUCA.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR000888. dTDP_sugar_isom.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR21047. PTHR21047. 1 hit.
PfamiPF00908. dTDP_sugar_isom. 1 hit.
[Graphical view]
ProDomiPD001462. dTDP_sugar_isom. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01221. rmlC. 1 hit.

Sequencei

Sequence statusi: Complete.

P37763-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIIDTALPD VKLLKPQVFT DGRGFFMETF RDGWFKENIA DRTFVQENHS
60 70 80 90 100
NSSKGVLRGL HYQTENTQGK LVRVVVGEVF DVAVDMREGS PTFGKWAGAT
110 120 130 140 150
LSAQNRYQLW IPEGFAHGFC VLGDAAEVVY KCTDYYNPET EQVLIWNDPA
160 170 180 190 200
IGIGWPLQTA PLLSPKDLAG KTWAQAEKSA LRFPDKKCRP NVSDGIFSDR
210 220 230 240 250
LPTRLQYALC KEKHPGNEER QAQPRSGGIP VLQIQRERRI RAAVGHREGN
260 270 280 290 300
NKRHNYTNQA FTDNQACREK RTDTVGVFQT AFAVFRLLAN DVFQHRRQHR
310 320
ACHDGHIDGR RQINAHTDRK DGQGKFTA
Length:328
Mass (Da):37,209
Last modified:October 1, 1994 - v1
Checksum:i20BA7BA065604D4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32742 Genomic DNA. Translation: CAA83654.1.
Z21508 Genomic DNA. Translation: CAA79720.1.
PIRiS47047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32742 Genomic DNA. Translation: CAA83654.1.
Z21508 Genomic DNA. Translation: CAA79720.1.
PIRiS47047.

3D structure databases

ProteinModelPortaliP37763.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi528357.NgonPI_010100010760.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108URP. Bacteria.
COG1898. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00124.
UPA00281.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR000888. dTDP_sugar_isom.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR21047. PTHR21047. 1 hit.
PfamiPF00908. dTDP_sugar_isom. 1 hit.
[Graphical view]
ProDomiPD001462. dTDP_sugar_isom. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01221. rmlC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRMLC_NEIGO
AccessioniPrimary (citable) accession number: P37763
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 5, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.