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P37763

- RMLC_NEIGO

UniProt

P37763 - RMLC_NEIGO

Protein

dTDP-4-dehydrorhamnose 3,5-epimerase

Gene

rfbC

Organism
Neisseria gonorrhoeae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.By similarity

    Catalytic activityi

    dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei23 – 231SubstrateBy similarity
    Binding sitei28 – 281SubstrateBy similarity
    Binding sitei46 – 461SubstrateBy similarity
    Binding sitei48 – 481SubstrateBy similarity
    Binding sitei58 – 581SubstrateBy similarity
    Binding sitei61 – 611SubstrateBy similarity
    Sitei61 – 611Important in abstrating the protons in C3' and C5'By similarity
    Binding sitei70 – 701SubstrateBy similarity
    Binding sitei81 – 811SubstrateBy similarity
    Binding sitei117 – 1171SubstrateBy similarity
    Sitei130 – 1301May have a key role in proton donation to C5'By similarity

    GO - Molecular functioni

    1. dTDP-4-dehydrorhamnose 3,5-epimerase activity Source: UniProtKB

    GO - Biological processi

    1. dTDP-rhamnose biosynthetic process Source: UniProtKB-UniPathway
    2. extracellular polysaccharide biosynthetic process Source: UniProtKB
    3. lipopolysaccharide biosynthetic process Source: UniProtKB
    4. O antigen biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00124.
    UPA00281.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    dTDP-4-dehydrorhamnose 3,5-epimerase (EC:5.1.3.13)
    Alternative name(s):
    Thymidine diphospho-4-keto-rhamnose 3,5-epimerase
    dTDP-4-keto-6-deoxyglucose 3,5-epimerase
    dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase
    dTDP-L-rhamnose synthase
    Gene namesi
    Name:rfbC
    Synonyms:rmlC
    OrganismiNeisseria gonorrhoeae
    Taxonomic identifieri485 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328dTDP-4-dehydrorhamnose 3,5-epimerasePRO_0000207981Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP37763.
    SMRiP37763. Positions 1-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni166 – 1672Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR000888. dTDP_sugar_isom.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR21047. PTHR21047. 1 hit.
    PfamiPF00908. dTDP_sugar_isom. 1 hit.
    [Graphical view]
    ProDomiPD001462. dTDP_sugar_isom. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01221. rmlC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P37763-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIIDTALPD VKLLKPQVFT DGRGFFMETF RDGWFKENIA DRTFVQENHS    50
    NSSKGVLRGL HYQTENTQGK LVRVVVGEVF DVAVDMREGS PTFGKWAGAT 100
    LSAQNRYQLW IPEGFAHGFC VLGDAAEVVY KCTDYYNPET EQVLIWNDPA 150
    IGIGWPLQTA PLLSPKDLAG KTWAQAEKSA LRFPDKKCRP NVSDGIFSDR 200
    LPTRLQYALC KEKHPGNEER QAQPRSGGIP VLQIQRERRI RAAVGHREGN 250
    NKRHNYTNQA FTDNQACREK RTDTVGVFQT AFAVFRLLAN DVFQHRRQHR 300
    ACHDGHIDGR RQINAHTDRK DGQGKFTA 328
    Length:328
    Mass (Da):37,209
    Last modified:October 1, 1994 - v1
    Checksum:i20BA7BA065604D4F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z32742 Genomic DNA. Translation: CAA83654.1.
    Z21508 Genomic DNA. Translation: CAA79720.1.
    PIRiS47047.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z32742 Genomic DNA. Translation: CAA83654.1 .
    Z21508 Genomic DNA. Translation: CAA79720.1 .
    PIRi S47047.

    3D structure databases

    ProteinModelPortali P37763.
    SMRi P37763. Positions 1-178.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00124 .
    UPA00281 .

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR000888. dTDP_sugar_isom.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR21047. PTHR21047. 1 hit.
    Pfami PF00908. dTDP_sugar_isom. 1 hit.
    [Graphical view ]
    ProDomi PD001462. dTDP_sugar_isom. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01221. rmlC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The identification of cryptic rhamnose biosynthesis genes in Neisseria gonorrhoeae and their relationship to lipopolysaccharide biosynthesis."
      Robertson B.D., Frosch M., van Putten J.P.M.
      J. Bacteriol. 176:6915-6920(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: MS11.
    2. "Genes associated with meningococcal capsule complex are also found in Neisseria gonorrhoeae."
      Petering H., Hammerschmidt S., Frosch M., van Putten J.P.M., Ison C.A., Robertson B.D.
      J. Bacteriol. 178:3342-3345(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: MS11.

    Entry informationi

    Entry nameiRMLC_NEIGO
    AccessioniPrimary (citable) accession number: P37763
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3