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P37763 (RMLC_NEIGO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
dTDP-4-dehydrorhamnose 3,5-epimerase
EC=5.1.3.13
Alternative name(s):
Thymidine diphospho-4-keto-rhamnose 3,5-epimerase
dTDP-4-keto-6-deoxyglucose 3,5-epimerase
dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase
dTDP-L-rhamnose synthase
Gene names
Name:rfbC
Synonyms:rmlC
OrganismNeisseria gonorrhoeae
Taxonomic identifier485 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose By similarity.

Catalytic activity

dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-beta-L-mannose.

Pathway

Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.

Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis.

Sequence similarities

Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328dTDP-4-dehydrorhamnose 3,5-epimerase
PRO_0000207981

Regions

Region166 – 1672Substrate binding By similarity

Sites

Binding site231Substrate By similarity
Binding site281Substrate By similarity
Binding site461Substrate By similarity
Binding site481Substrate By similarity
Binding site581Substrate By similarity
Binding site611Substrate By similarity
Binding site701Substrate By similarity
Binding site811Substrate By similarity
Binding site1171Substrate By similarity
Site611Important in abstrating the protons in C3' and C5' By similarity
Site1301May have a key role in proton donation to C5' By similarity

Sequences

Sequence LengthMass (Da)Tools
P37763 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 20BA7BA065604D4F

FASTA32837,209
        10         20         30         40         50         60 
MDIIDTALPD VKLLKPQVFT DGRGFFMETF RDGWFKENIA DRTFVQENHS NSSKGVLRGL 

        70         80         90        100        110        120 
HYQTENTQGK LVRVVVGEVF DVAVDMREGS PTFGKWAGAT LSAQNRYQLW IPEGFAHGFC 

       130        140        150        160        170        180 
VLGDAAEVVY KCTDYYNPET EQVLIWNDPA IGIGWPLQTA PLLSPKDLAG KTWAQAEKSA 

       190        200        210        220        230        240 
LRFPDKKCRP NVSDGIFSDR LPTRLQYALC KEKHPGNEER QAQPRSGGIP VLQIQRERRI 

       250        260        270        280        290        300 
RAAVGHREGN NKRHNYTNQA FTDNQACREK RTDTVGVFQT AFAVFRLLAN DVFQHRRQHR 

       310        320 
ACHDGHIDGR RQINAHTDRK DGQGKFTA

« Hide

References

[1]"The identification of cryptic rhamnose biosynthesis genes in Neisseria gonorrhoeae and their relationship to lipopolysaccharide biosynthesis."
Robertson B.D., Frosch M., van Putten J.P.M.
J. Bacteriol. 176:6915-6920(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: MS11.
[2]"Genes associated with meningococcal capsule complex are also found in Neisseria gonorrhoeae."
Petering H., Hammerschmidt S., Frosch M., van Putten J.P.M., Ison C.A., Robertson B.D.
J. Bacteriol. 178:3342-3345(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: MS11.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z32742 Genomic DNA. Translation: CAA83654.1.
Z21508 Genomic DNA. Translation: CAA79720.1.
PIRS47047.

3D structure databases

ProteinModelPortalP37763.
SMRP37763. Positions 1-178.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00124.
UPA00281.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR000888. dTDP_sugar_isom.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR21047. PTHR21047. 1 hit.
PfamPF00908. dTDP_sugar_isom. 1 hit.
[Graphical view]
ProDomPD001462. dTDP_sugar_isom. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMsTIGR01221. rmlC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRMLC_NEIGO
AccessionPrimary (citable) accession number: P37763
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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