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Protein

O-antigen polymerase

Gene

rfc

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Biological processi

Keywordsi

Biological processLipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:EG11982-MONOMER
UniPathwayiUPA00030

Protein family/group databases

TCDBi9.B.67.2.1 the o-antigen polymerase (oap) family

Names & Taxonomyi

Protein namesi
Recommended name:
O-antigen polymerase
Gene namesi
Name:rfc
Synonyms:yefF
Ordered Locus Names:b2035, JW2020
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG11982 rfc

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000972981 – 388O-antigen polymeraseAdd BLAST388

Proteomic databases

PaxDbiP37748
PRIDEiP37748

Interactioni

Protein-protein interaction databases

BioGridi4261358, 168 interactors
STRINGi316385.ECDH10B_2185

Structurei

3D structure databases

ProteinModelPortaliP37748
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107B0W Bacteria
ENOG410Z7XC LUCA
KOiK13008
OMAiTWNLEVY

Sequencei

Sequence statusi: Complete.

P37748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYLVISVFL ITAFICLYLK KDIFYPAVCV NIIFALVLLG YEITSDIYAF
60 70 80 90 100
QLNDATLIFL LCNVLTFTLS CLLTESVLDL NIRKVNNAIY SIPSKKVHNV
110 120 130 140 150
GLLVISFSMI YICMRLSNYQ FGTSLLSYMN LIRDADVEDT SRNFSAYMQP
160 170 180 190 200
IILTTFALFI WSKKFTNTKV SKTFTLLVFI VFIFAIILNT GKQIVFMVII
210 220 230 240 250
SYAFIVGVNR VKHYVYLITA VGVLFSLYML FLRGLPGGMA YYLSMYLVSP
260 270 280 290 300
IIAFQEFYFQ QVSNSASSHV FWFFERLMGL LTGGVSMSLH KEFVWVGLPT
310 320 330 340 350
NVYTAFSDYV YISAELSYLM MVIHGCISGV LWRLSRNYIS VKIFYSYFIY
360 370 380
TFSFIFYHES FMTNISSWIQ ITLCIIVFSQ FLKAQKIK
Length:388
Mass (Da):44,744
Last modified:October 1, 1994 - v1
Checksum:iF6B6A10DBA0199FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03041 Genomic DNA Translation: AAC31633.1
U09876 Genomic DNA Translation: AAB88404.1
U00096 Genomic DNA Translation: AAC75096.1
AP009048 Genomic DNA Translation: BAA15877.1
PIRiI69644
RefSeqiNP_416539.1, NC_000913.3
WP_000639866.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75096; AAC75096; b2035
BAA15877; BAA15877; BAA15877
GeneIDi945179
KEGGiecj:JW2020
eco:b2035
PATRICifig|1411691.4.peg.216

Entry informationi

Entry nameiRFC_ECOLI
AccessioniPrimary (citable) accession number: P37748
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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