Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative O-antigen transporter

Gene

rfbX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the translocation process of the nascent O-polysaccharide molecules and/or its ligation to lipid A core units.

Pathwayi: LPS O-antigen biosynthesis

This protein is involved in the pathway LPS O-antigen biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway LPS O-antigen biosynthesis and in Bacterial outer membrane biogenesis.

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoCyc
  • O antigen biosynthetic process Source: UniProtKB-UniPathway
  • response to antibiotic Source: EcoCyc

Keywordsi

Biological processLipopolysaccharide biosynthesis, Transport

Enzyme and pathway databases

BioCyciEcoCyc:RFBX-MONOMER
MetaCyc:RFBX-MONOMER
UniPathwayiUPA00281

Protein family/group databases

TCDBi2.A.66.2.1 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Putative O-antigen transporter
Gene namesi
Name:rfbX
Synonyms:wzx
Ordered Locus Names:b2037, JW2022
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11980 rfbX

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 41PeriplasmicSequence analysis9
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 83CytoplasmicSequence analysisAdd BLAST21
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 117PeriplasmicSequence analysisAdd BLAST13
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 173CytoplasmicSequence analysisAdd BLAST35
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 220PeriplasmicSequence analysisAdd BLAST26
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Topological domaini242 – 295CytoplasmicSequence analysisAdd BLAST54
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 328PeriplasmicSequence analysisAdd BLAST12
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 362CytoplasmicSequence analysisAdd BLAST13
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 385PeriplasmicSequence analysis2
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Topological domaini407 – 415CytoplasmicSequence analysis9

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001664491 – 415Putative O-antigen transporterAdd BLAST415

Proteomic databases

PaxDbiP37746
PRIDEiP37746

Interactioni

Protein-protein interaction databases

BioGridi4259620, 173 interactors
STRINGi316385.ECDH10B_2187

Structurei

3D structure databases

ProteinModelPortaliP37746
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polysaccharide synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105ER6 Bacteria
COG2244 LUCA
HOGENOMiHOG000176959
InParanoidiP37746
KOiK18799
OMAiIRTQYLI
PhylomeDBiP37746

Family and domain databases

InterProiView protein in InterPro
IPR002797 Polysacc_synth
PfamiView protein in Pfam
PF01943 Polysacc_synt, 1 hit

Sequencei

Sequence statusi: Complete.

P37746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTNKLSLRR NVIYLAVVQG SNYLLPLLTF PYLVRTLGPE NFGIFGFCQA
60 70 80 90 100
TMLYMIMFVE YGFNLTATQS IAKAADSKDK VTSIFWAVIF SKIVLIVITL
110 120 130 140 150
IFLTSMTLLV PEYNKHAVII WSFVPALVGN LIYPIWLFQG KEKMKWLTLS
160 170 180 190 200
SILSRLAIIP LTFIFVNTKS DIAIAGFIQS SANLVAGIIA LAIVVHEGWI
210 220 230 240 250
GKVTLSLHNV RRSLADGFHV FISTSAISLY STGIVIILGF ISGPTSVGNF
260 270 280 290 300
NAANTIRNAL QGLLNPITQA IYPRISSTLV LNRVKGVILI KKSLTCLSLI
310 320 330 340 350
GGAFSLILLL GASILVKISI GPGYDNAVIV LMIISPLPFL ISLSNVYGIQ
360 370 380 390 400
VMLTHNYKKE FSKILIAAGL LSLLLIFPLT TLFKEIGAAI TLLATECLVT
410
SLMLMFVRNN KLLVC
Length:415
Mass (Da):45,383
Last modified:May 30, 2000 - v4
Checksum:iBE902BE9241CBA5F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236I → V in AAC31631 (PubMed:7517390).Curated1
Sequence conflicti350Q → R in AAC31631 (PubMed:7517390).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03041 Genomic DNA Translation: AAC31631.1
U09876 Genomic DNA Translation: AAB88402.1
U00096 Genomic DNA Translation: AAC75098.1
AP009048 Genomic DNA Translation: BAA15879.1
PIRiD64969
RefSeqiNP_416541.1, NC_000913.3
WP_001393538.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75098; AAC75098; b2037
BAA15879; BAA15879; BAA15879
GeneIDi946557
KEGGiecj:JW2022
eco:b2037
PATRICifig|1411691.4.peg.214

Similar proteinsi

Entry informationi

Entry nameiRFBX_ECOLI
AccessioniPrimary (citable) accession number: P37746
Secondary accession number(s): P76376
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 130 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health