P37714 (LYSC2_CAPHI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Lysozyme C-2 EC=3.2.1.17 Alternative name(s): 1,4-beta-N-acetylmuramidase C-2
Organism	Capra hircus (Goat)
Taxonomic identifier	9925 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Capra

Protein attributes

Sequence length	129 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subunit structure	Monomer By similarity.
Miscellaneous	Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Biological process	Digestion
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW digestion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 129	129	Lysozyme C-2		PRO_0000208848
Sites
	Active site	35	1	By similarity
	Active site	53	1	By similarity
Amino acid modifications
	Disulfide bond	6 ↔ 127		By similarity
	Disulfide bond	30 ↔ 115		By similarity
	Disulfide bond	65 ↔ 81		By similarity
	Disulfide bond	77 ↔ 95		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P37714 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: AA04FDBF67D0783E	FASTA	129	14,337
	10 20 30 40 50 60 KVFERCELAR TLKELGLDGY KGVSLANWLC LTKWESSYNT KATNYNPGSE STDYGIFQIN 70 80 90 100 110 120 SKFWCNDGKT PNAVDGCHVS CSELMENNIA KAVACAKQIV SEQGITAWVA WKSHCRDHDV SSYVEGCTL

References

[1]	"Amino acid sequences of stomach and nonstomach lysozymes of ruminants." Jolles J., Prager E.M., Alnemri E.S., Jolles P., Ibrahimi I.M., Wilson A.C. J. Mol. Evol. 30:370-382(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Stomach.
[2]	Erratum Jolles J., Prager E.M., Alnemri E.S., Jolles P., Ibrahimi I.M., Wilson A.C. J. Mol. Evol. 30:563-563(1990)

Cross-references

3D structure databases
ProteinModelPortal	P37714.
SMR	P37714. Positions 1-129.
ModBase	Search...
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG052297.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR019799. Glyco_hydro_22_CS. IPR000974. Glyco_hydro_22_lys. IPR023346. Lysozyme-like_dom. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LYSC2_CAPHI

Accession

Primary (citable) accession number: P37714

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program