Reviewed, UniProtKB/Swiss-Prot P37712 (LYSC_CAMDR)

Names and origin

Protein names

Recommended name:
    Lysozyme C
    EC=3.2.1.17
Alternative name(s):
    1,4-beta-N-acetylmuramidase

Gene names

Name:

LYZ

Organism

Camelus dromedarius (Dromedary) (Arabian camel)

Taxonomic identifier

9838 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Tylopoda › Camelidae › Camelus

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subunit structure	Monomer By similarity.
Miscellaneous	Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Biological process	Digestion
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW digestion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 130	130	Lysozyme C		PRO_0000208844
Sites
	Active site	35	1	By similarity
	Active site	53	1	By similarity
Amino acid modifications
	Disulfide bond	6 ↔ 128		By similarity
	Disulfide bond	30 ↔ 116		By similarity
	Disulfide bond	65 ↔ 81		By similarity
	Disulfide bond	77 ↔ 95		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P37712-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 6CFFCB41B02FD287	FASTA	130	14,795
	10 20 30 40 50 60 KVWERCALAR KLKELGMDGY RGVSLANWMC LTKWESDYNT DATNYNPSSE STDYGIFQIN 70 80 90 100 110 120 SRYWCNNGKT PHAVNGCGIN CNVLLEDDIT KAVQCAKRVV RDPQGVRAWV AWKNHCEGHD 130 VEQYVEGCDL

References

[1]	"Amino acid sequences of stomach and nonstomach lysozymes of ruminants." Jolles J., Prager E.M., Alnemri E.S., Jolles P., Ibrahimi I.M., Wilson A.C. J. Mol. Evol. 30:370-382(1990) [PubMed: 2111849] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Stomach.
[2]	Erratum Jolles J., Prager E.M., Alnemri E.S., Jolles P., Ibrahimi I.M., Wilson A.C. J. Mol. Evol. 30:563-563(1990)

Cross-references

3D structure databases
HSSP	HSSP built from PDB template 1LHL based on UniProtKB P00695.
ModBase	Search...
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Phylogenomic databases
HOVERGEN	P37712.
Enzyme and pathway databases
BRENDA	3.2.1.17. 9075.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR019799. Glyco_hydro_22_CS. IPR000974. Glyco_hydro_22_lys. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LYSC_CAMDR

Accession

Primary (citable) accession number: P37712

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)