Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Autolysin

Gene

EF_0799

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes the cell wall of E.faecalis and M.lysodeikticus. May play an important role in cell wall growth and cell separation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase
Biological processCell cycle, Cell division, Cell wall biogenesis/degradation, Septation

Enzyme and pathway databases

BioCyciEFAE226185:G1G0C-781-MONOMER

Protein family/group databases

CAZyiCBM50 Carbohydrate-Binding Module Family 50
GH73 Glycoside Hydrolase Family 73

Names & Taxonomyi

Protein namesi
Recommended name:
Autolysin (EC:3.2.1.-)
Alternative name(s):
Beta-glycosidase
Peptidoglycan hydrolase
Gene namesi
Ordered Locus Names:EF_0799
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000001415 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 53Sequence analysisAdd BLAST53
ChainiPRO_000001211554 – 737AutolysinAdd BLAST684

Proteomic databases

PRIDEiP37710

Interactioni

Protein-protein interaction databases

IntActiP37710, 2 interactors
STRINGi226185.EF0799

Structurei

Secondary structure

1737
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi429 – 432Combined sources4
Helixi439 – 446Combined sources8
Helixi450 – 457Combined sources8
Beta strandi469 – 472Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MKXNMR-A426-475[»]
ProteinModelPortaliP37710
SMRiP37710
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini361 – 404LysM 1PROSITE-ProRule annotationAdd BLAST44
Domaini429 – 472LysM 2PROSITE-ProRule annotationAdd BLAST44
Domaini497 – 540LysM 3PROSITE-ProRule annotationAdd BLAST44
Domaini565 – 608LysM 4PROSITE-ProRule annotationAdd BLAST44
Domaini631 – 674LysM 5PROSITE-ProRule annotationAdd BLAST44
Domaini693 – 736LysM 6PROSITE-ProRule annotationAdd BLAST44

Domaini

LysM domains are thought to be involved in peptidoglycan binding.

Sequence similaritiesi

Belongs to the glycosyl hydrolase 73 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4107X35 Bacteria
COG1388 LUCA
COG1705 LUCA
OMAiNIYIGQK

Family and domain databases

CDDicd00118 LysM, 6 hits
Gene3Di3.10.350.10, 6 hits
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR002901 MGlyc_endo_b_GlcNAc-like_dom
PfamiView protein in Pfam
PF01832 Glucosaminidase, 1 hit
PF01476 LysM, 6 hits
SMARTiView protein in SMART
SM00257 LysM, 6 hits
SM00047 LYZ2, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKESMSRIE RRKAQQRKKT PVQWKKSTTL FSSALIVSSV GTPVALLPVT
60 70 80 90 100
AEATEEQPTN AEVAQAPTTE TGLVETPTTE TTPGTTEQPT TDSSTTTEST
110 120 130 140 150
TESSKETPTT PSTEQPTADS TTPVESGTTD SSVAEITPVA PSATESEAAP
160 170 180 190 200
AVTPDDEVKV PEARVASAQT FSALSPTQSP SEFIAELARC AQPIAQANDL
210 220 230 240 250
YASVMMAQAI VESGWGASTL SKAPNYNLFG IKGSYNGQSV YMDTWEYLNG
260 270 280 290 300
KWLVKKEPFR KYPSYMESFQ DNAHVLKTTS FQAGVYYYAG AWKSNTSSYR
310 320 330 340 350
DATAWLTGRY ATDPSYNAKL NNVITAYNLT QYDTPSSGGN TGGGTVNPGT
360 370 380 390 400
GGSNNQSGTN TYYTVKSGDT LNKIAAQYGV SVANLRSWNG ISGDLIFVGQ
410 420 430 440 450
KLIVKKGASG NTGGSGSGGS NNNQSGTNTY YTVKSGDTLN KIAAQYGVSV
460 470 480 490 500
ANLRSWNGIS GDLIFVGQKL IVKKGASGNT GGSNNGGSNN NQSGTNTYYT
510 520 530 540 550
IKSGDTLNKI AAQYGVSVAN LRSWNGISGD LIFAGQKIIV KKGTSGNTGG
560 570 580 590 600
SSNGGSNNNQ SGTNTYYTIK SGDTLNKISA QFGVSVANLQ AWNNISGSLI
610 620 630 640 650
FAGQKIIVKK GANSGSTNTN KPTNNGGGAT TSYTIKSGDT LNKISAQFGV
660 670 680 690 700
SVANLRSWNG IKGDLIFAGQ TIIVKKGASA GGNASSTNSA SGKRHTVKSG
710 720 730
DSLWGLSMQY GISIQKIKQL NGLSGDTIYI GQTLKVG
Length:737
Mass (Da):77,025
Last modified:April 23, 2003 - v2
Checksum:iABB16BD506AC7507
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85T → I in AAA67325 (PubMed:1679432).Curated1
Sequence conflicti118A → V in AAA67325 (PubMed:1679432).Curated1
Sequence conflicti143A → T in AAA67325 (PubMed:1679432).Curated1
Sequence conflicti417S → N in AAA67325 (PubMed:1679432).Curated1
Sequence conflicti449S → T in AAA67325 (PubMed:1679432).Curated1
Sequence conflicti476A → T in AAA67325 (PubMed:1679432).Curated1
Sequence conflicti484N → S in AAA67325 (PubMed:1679432).Curated1
Sequence conflicti567 – 632Missing (PubMed:1679432).CuratedAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58002 Genomic DNA Translation: AAA67325.1
AE016830 Genomic DNA Translation: AAO80613.1
PIRiA38109
RefSeqiNP_814543.1, NC_004668.1
WP_010706701.1, NZ_KE136527.1

Genome annotation databases

EnsemblBacteriaiAAO80613; AAO80613; EF_0799
GeneIDi1199693
KEGGiefa:EF0799
PATRICifig|226185.45.peg.2736

Similar proteinsi

Entry informationi

Entry nameiALYS_ENTFA
AccessioniPrimary (citable) accession number: P37710
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: April 23, 2003
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health