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Protein

Endoglucanase F

Gene

celCCF

Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable endoglucanase involved in the degradation of cellulose or related beta-glucans.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BRENDAi3.2.1.4. 1468.

Protein family/group databases

CAZyiGH48. Glycoside Hydrolase Family 48.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase F (EC:3.2.1.4)
Alternative name(s):
Cellulase F
EGCCF
Endo-1,4-beta-glucanase F
Gene namesi
Name:celCCF
Ordered Locus Names:Ccel_0729
OrganismiClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Taxonomic identifieri394503 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000001349 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000802630 – 722Endoglucanase FAdd BLAST693

Interactioni

Protein-protein interaction databases

STRINGi394503.Ccel_0729.

Structurei

Secondary structure

1722
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi36 – 50Combined sources15
Helixi52 – 54Combined sources3
Beta strandi65 – 67Combined sources3
Beta strandi73 – 77Combined sources5
Beta strandi80 – 82Combined sources3
Helixi83 – 100Combined sources18
Helixi104 – 116Combined sources13
Turni121 – 123Combined sources3
Helixi126 – 129Combined sources4
Helixi147 – 149Combined sources3
Beta strandi151 – 153Combined sources3
Helixi166 – 173Combined sources8
Beta strandi174 – 177Combined sources4
Beta strandi182 – 186Combined sources5
Beta strandi190 – 192Combined sources3
Beta strandi202 – 207Combined sources6
Helixi217 – 219Combined sources3
Beta strandi223 – 227Combined sources5
Beta strandi229 – 233Combined sources5
Helixi238 – 240Combined sources3
Beta strandi251 – 256Combined sources6
Helixi258 – 276Combined sources19
Turni277 – 279Combined sources3
Helixi283 – 295Combined sources13
Helixi296 – 300Combined sources5
Beta strandi310 – 314Combined sources5
Helixi318 – 320Combined sources3
Beta strandi330 – 337Combined sources8
Beta strandi340 – 343Combined sources4
Beta strandi346 – 349Combined sources4
Helixi350 – 352Combined sources3
Helixi355 – 363Combined sources9
Helixi365 – 367Combined sources3
Beta strandi370 – 373Combined sources4
Helixi374 – 391Combined sources18
Beta strandi395 – 397Combined sources3
Beta strandi402 – 407Combined sources6
Turni408 – 411Combined sources4
Beta strandi424 – 429Combined sources6
Turni433 – 438Combined sources6
Helixi442 – 458Combined sources17
Helixi461 – 475Combined sources15
Beta strandi486 – 496Combined sources11
Turni503 – 505Combined sources3
Beta strandi514 – 521Combined sources8
Helixi524 – 541Combined sources18
Helixi544 – 560Combined sources17
Beta strandi561 – 563Combined sources3
Beta strandi570 – 572Combined sources3
Turni574 – 577Combined sources4
Helixi578 – 581Combined sources4
Helixi606 – 609Combined sources4
Helixi611 – 615Combined sources5
Helixi619 – 627Combined sources9
Beta strandi633 – 635Combined sources3
Helixi639 – 655Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F9DX-ray2.30A30-658[»]
1F9OX-ray2.50A30-658[»]
1FAEX-ray2.00A30-658[»]
1FBOX-ray2.30A30-658[»]
1FBWX-ray2.00A30-658[»]
1FCEX-ray2.00A30-658[»]
1G9GX-ray1.90A30-658[»]
1G9JX-ray1.90A30-658[»]
2QNOX-ray2.00A30-658[»]
ProteinModelPortaliP37698.
SMRiP37698.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37698.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini661 – 722DockerinPROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Contains 1 dockerin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105CYP. Bacteria.
ENOG410XPC9. LUCA.
HOGENOMiHOG000020369.
OMAiKYTNAPD.
OrthoDBiPOG091H0EGP.

Family and domain databases

Gene3Di1.10.1330.10. 1 hit.
1.50.10.10. 4 hits.
4.10.870.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR002105. Dockerin_1_rpt.
IPR016134. Dockerin_dom.
IPR027390. Endoglucanase_F_dom3.
IPR000556. Glyco_hydro_48F.
[Graphical view]
PfamiPF00404. Dockerin_1. 2 hits.
PF02011. Glyco_hydro_48. 1 hit.
[Graphical view]
PRINTSiPR00844. GLHYDRLASE48.
SUPFAMiSSF48208. SSF48208. 1 hit.
SSF63446. SSF63446. 1 hit.
PROSITEiPS00448. CLOS_CELLULOSOME_RPT. 2 hits.
PS51766. DOCKERIN. 1 hit.
PS00018. EF_HAND_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37698-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNFKRVGA VAVAAAMSLS IMATTSINAA SSPANKVYQD RFESMYSKIK
60 70 80 90 100
DPANGYFSEQ GIPYHSIETL MVEAPDYGHV TTSEAMSYYM WLEAMHGRFS
110 120 130 140 150
GDFTGFDKSW SVTEQYLIPT EKDQPNTSMS RYDANKPATY APEFQDPSKY
160 170 180 190 200
PSPLDTSQPV GRDPINSQLT SAYGTSMLYG MHWILDVDNW YGFGARADGT
210 220 230 240 250
SKPSYINTFQ RGEQESTWET IPQPCWDEHK FGGQYGFLDL FTKDTGTPAK
260 270 280 290 300
QFKYTNAPDA DARAVQATYW ADQWAKEQGK SVSTSVGKAT KMGDYLRYSF
310 320 330 340 350
FDKYFRKIGQ PSQAGTGYDA AHYLLSWYYA WGGGIDSTWS WIIGSSHNHF
360 370 380 390 400
GYQNPFAAWV LSTDANFKPK SSNGASDWAK SLDRQLEFYQ WLQSAEGAIA
410 420 430 440 450
GGATNSWNGR YEAVPSGTST FYGMGYVENP VYADPGSNTW FGMQVWSMQR
460 470 480 490 500
VAELYYKTGD ARAKKLLDKW AKWINGEIKF NADGTFQIPS TIDWEGQPDT
510 520 530 540 550
WNPTQGYTGN ANLHVKVVNY GTDLGCASSL ANTLTYYAAK SGDETSRQNA
560 570 580 590 600
QKLLDAMWNN YSDSKGISTV EQRGDYHRFL DQEVFVPAGW TGKMPNGDVI
610 620 630 640 650
KSGVKFIDIR SKYKQDPEWQ TMVAALQAGQ VPTQRLHRFW AQSEFAVANG
660 670 680 690 700
VYAILFPDQG PEKLLGDVNG DETVDAIDLA ILKKYLLNSS TTINTANADM
710 720
NSDNAIDAID YALLKKALLS IQ
Length:722
Mass (Da):80,544
Last modified:October 1, 1996 - v2
Checksum:i5E48F85319D70AE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30321 Genomic DNA. Translation: AAB41452.1.
CP001348 Genomic DNA. Translation: ACL75108.1.
M87018 Genomic DNA. Translation: AAA73866.1.
PIRiPC1139.
RefSeqiWP_015924275.1. NC_011898.1.

Genome annotation databases

EnsemblBacteriaiACL75108; ACL75108; Ccel_0729.
KEGGicce:Ccel_0729.
PATRICi19432255. VBICloCel57783_0754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30321 Genomic DNA. Translation: AAB41452.1.
CP001348 Genomic DNA. Translation: ACL75108.1.
M87018 Genomic DNA. Translation: AAA73866.1.
PIRiPC1139.
RefSeqiWP_015924275.1. NC_011898.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F9DX-ray2.30A30-658[»]
1F9OX-ray2.50A30-658[»]
1FAEX-ray2.00A30-658[»]
1FBOX-ray2.30A30-658[»]
1FBWX-ray2.00A30-658[»]
1FCEX-ray2.00A30-658[»]
1G9GX-ray1.90A30-658[»]
1G9JX-ray1.90A30-658[»]
2QNOX-ray2.00A30-658[»]
ProteinModelPortaliP37698.
SMRiP37698.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi394503.Ccel_0729.

Protein family/group databases

CAZyiGH48. Glycoside Hydrolase Family 48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL75108; ACL75108; Ccel_0729.
KEGGicce:Ccel_0729.
PATRICi19432255. VBICloCel57783_0754.

Phylogenomic databases

eggNOGiENOG4105CYP. Bacteria.
ENOG410XPC9. LUCA.
HOGENOMiHOG000020369.
OMAiKYTNAPD.
OrthoDBiPOG091H0EGP.

Enzyme and pathway databases

BRENDAi3.2.1.4. 1468.

Miscellaneous databases

EvolutionaryTraceiP37698.

Family and domain databases

Gene3Di1.10.1330.10. 1 hit.
1.50.10.10. 4 hits.
4.10.870.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR002105. Dockerin_1_rpt.
IPR016134. Dockerin_dom.
IPR027390. Endoglucanase_F_dom3.
IPR000556. Glyco_hydro_48F.
[Graphical view]
PfamiPF00404. Dockerin_1. 2 hits.
PF02011. Glyco_hydro_48. 1 hit.
[Graphical view]
PRINTSiPR00844. GLHYDRLASE48.
SUPFAMiSSF48208. SSF48208. 1 hit.
SSF63446. SSF63446. 1 hit.
PROSITEiPS00448. CLOS_CELLULOSOME_RPT. 2 hits.
PS51766. DOCKERIN. 1 hit.
PS00018. EF_HAND_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUNF_CLOCE
AccessioniPrimary (citable) accession number: P37698
Secondary accession number(s): B8I7V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.