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P37696

- GUNA_KOMHA

UniProt

P37696 - GUNA_KOMHA

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Protein
Probable endoglucanase
Gene
cmcAX
Organism
Komagataeibacter hansenii (Gluconacetobacter hansenii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Enzyme capable of hydrolyzing carboxy-methyl-cellulose (CMC).

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei57 – 571Proton donor By similarity
Active sitei114 – 1141Nucleophile Reviewed prediction

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1558-MONOMER.

Protein family/group databases

CAZyiGH8. Glycoside Hydrolase Family 8.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endoglucanase (EC:3.2.1.4)
Alternative name(s):
Cellulase
Endo-1,4-beta-glucanase
Gene namesi
Name:cmcAX
OrganismiKomagataeibacter hansenii (Gluconacetobacter hansenii)
Taxonomic identifieri436 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeKomagataeibacter

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 Publication
Add
BLAST
Chaini21 – 342322Probable endoglucanase
PRO_0000007930Add
BLAST

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 3813
Beta strandi48 – 514
Beta strandi53 – 553
Helixi56 – 6914
Helixi72 – 8514
Beta strandi89 – 924
Beta strandi96 – 994
Beta strandi102 – 1065
Helixi113 – 13018
Helixi133 – 15018
Beta strandi151 – 1544
Beta strandi157 – 1604
Beta strandi164 – 1663
Beta strandi170 – 1756
Helixi177 – 1793
Helixi182 – 19211
Helixi196 – 21015
Turni214 – 2174
Beta strandi221 – 2266
Turni227 – 2293
Beta strandi232 – 2343
Beta strandi240 – 2423
Turni244 – 2474
Helixi248 – 2558
Helixi261 – 27414
Turni285 – 2873
Beta strandi292 – 2943
Helixi297 – 3059
Helixi317 – 3193
Helixi323 – 33917

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WZZX-ray1.65A21-342[»]
ProteinModelPortaliP37696.
SMRiP37696. Positions 23-341.

Miscellaneous databases

EvolutionaryTraceiP37696.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR002037. Glyco_hydro_8.
IPR019834. Glyco_hydro_8_CS.
[Graphical view]
PfamiPF01270. Glyco_hydro_8. 1 hit.
[Graphical view]
PRINTSiPR00735. GLHYDRLASE8.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00812. GLYCOSYL_HYDROL_F8. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37696-1 [UniParc]FASTAAdd to Basket

« Hide

MSVMAAMGGA QVLSSTGAFA DPAPDAVAQQ WAIFRAKYLR PSGRVVDTGN    50
GGESHSEGQG YGMLFAASAG DLASFQSMWM WARTNLQHTN DKLFSWRFLK 100
GHQPPVPDKN NATDGDLLIA LALGRAGKRF QRPDYIQDAM AIYGDVLNLM 150
TMKAGPYVVL MPGAVGFTKK DSVILNLSYY VMPSLLQAFD LTADPRWRQV 200
MEDGIRLVSA GRFGQWRLPP DWLAVNRATG ALSIASGWPP RFSYDAIRVP 250
LYFYWAHMLA PNVLADFTRF WNNFGANALP GWVDLTTGAR SPYNAPPGYL 300
AVAECTGLDS AGELPTLDHA PDYYSAALTL LVYIARAEET IK 342
Length:342
Mass (Da):37,443
Last modified:October 1, 1994 - v1
Checksum:i85FF9BDF8B979F81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96060 Unassigned DNA. Translation: AAA16969.1.
PIRiA36963.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96060 Unassigned DNA. Translation: AAA16969.1 .
PIRi A36963.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WZZ X-ray 1.65 A 21-342 [» ]
ProteinModelPortali P37696.
SMRi P37696. Positions 23-341.
ModBasei Search...

Protein family/group databases

CAZyi GH8. Glycoside Hydrolase Family 8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-1558-MONOMER.

Miscellaneous databases

EvolutionaryTracei P37696.

Family and domain databases

Gene3Di 1.50.10.10. 1 hit.
InterProi IPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR002037. Glyco_hydro_8.
IPR019834. Glyco_hydro_8_CS.
[Graphical view ]
Pfami PF01270. Glyco_hydro_8. 1 hit.
[Graphical view ]
PRINTSi PR00735. GLHYDRLASE8.
SUPFAMi SSF48208. SSF48208. 1 hit.
PROSITEi PS00812. GLYCOSYL_HYDROL_F8. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A new gene required for cellulose production and a gene encoding cellulolytic activity in Acetobacter xylinum are colocalized with the bcs operon."
    Standal R., Iversen T.-G., Coucheron D.H., Fjaervik E., Blatny J.M., Valla S.
    J. Bacteriol. 176:665-672(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 21-34.
    Strain: ATCC 23769 / NCIMB 8246.

Entry informationi

Entry nameiGUNA_KOMHA
AccessioniPrimary (citable) accession number: P37696
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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