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P37696

- GUNA_KOMHA

UniProt

P37696 - GUNA_KOMHA

Protein

Probable endoglucanase

Gene

cmcAX

Organism
Komagataeibacter hansenii (Gluconacetobacter hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Enzyme capable of hydrolyzing carboxy-methyl-cellulose (CMC).

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei57 – 571Proton donorBy similarity
    Active sitei114 – 1141NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. cellulase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-1558-MONOMER.

    Protein family/group databases

    CAZyiGH8. Glycoside Hydrolase Family 8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable endoglucanase (EC:3.2.1.4)
    Alternative name(s):
    Cellulase
    Endo-1,4-beta-glucanase
    Gene namesi
    Name:cmcAX
    OrganismiKomagataeibacter hansenii (Gluconacetobacter hansenii)
    Taxonomic identifieri436 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeKomagataeibacter

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20201 PublicationAdd
    BLAST
    Chaini21 – 342322Probable endoglucanasePRO_0000007930Add
    BLAST

    Structurei

    Secondary structure

    1
    342
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi26 – 3813
    Beta strandi48 – 514
    Beta strandi53 – 553
    Helixi56 – 6914
    Helixi72 – 8514
    Beta strandi89 – 924
    Beta strandi96 – 994
    Beta strandi102 – 1065
    Helixi113 – 13018
    Helixi133 – 15018
    Beta strandi151 – 1544
    Beta strandi157 – 1604
    Beta strandi164 – 1663
    Beta strandi170 – 1756
    Helixi177 – 1793
    Helixi182 – 19211
    Helixi196 – 21015
    Turni214 – 2174
    Beta strandi221 – 2266
    Turni227 – 2293
    Beta strandi232 – 2343
    Beta strandi240 – 2423
    Turni244 – 2474
    Helixi248 – 2558
    Helixi261 – 27414
    Turni285 – 2873
    Beta strandi292 – 2943
    Helixi297 – 3059
    Helixi317 – 3193
    Helixi323 – 33917

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WZZX-ray1.65A21-342[»]
    ProteinModelPortaliP37696.
    SMRiP37696. Positions 23-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP37696.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di1.50.10.10. 1 hit.
    InterProiIPR008928. 6-hairpin_glycosidase-like.
    IPR012341. 6hp_glycosidase.
    IPR002037. Glyco_hydro_8.
    IPR019834. Glyco_hydro_8_CS.
    [Graphical view]
    PfamiPF01270. Glyco_hydro_8. 1 hit.
    [Graphical view]
    PRINTSiPR00735. GLHYDRLASE8.
    SUPFAMiSSF48208. SSF48208. 1 hit.
    PROSITEiPS00812. GLYCOSYL_HYDROL_F8. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P37696-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVMAAMGGA QVLSSTGAFA DPAPDAVAQQ WAIFRAKYLR PSGRVVDTGN    50
    GGESHSEGQG YGMLFAASAG DLASFQSMWM WARTNLQHTN DKLFSWRFLK 100
    GHQPPVPDKN NATDGDLLIA LALGRAGKRF QRPDYIQDAM AIYGDVLNLM 150
    TMKAGPYVVL MPGAVGFTKK DSVILNLSYY VMPSLLQAFD LTADPRWRQV 200
    MEDGIRLVSA GRFGQWRLPP DWLAVNRATG ALSIASGWPP RFSYDAIRVP 250
    LYFYWAHMLA PNVLADFTRF WNNFGANALP GWVDLTTGAR SPYNAPPGYL 300
    AVAECTGLDS AGELPTLDHA PDYYSAALTL LVYIARAEET IK 342
    Length:342
    Mass (Da):37,443
    Last modified:October 1, 1994 - v1
    Checksum:i85FF9BDF8B979F81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96060 Unassigned DNA. Translation: AAA16969.1.
    PIRiA36963.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96060 Unassigned DNA. Translation: AAA16969.1 .
    PIRi A36963.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WZZ X-ray 1.65 A 21-342 [» ]
    ProteinModelPortali P37696.
    SMRi P37696. Positions 23-341.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH8. Glycoside Hydrolase Family 8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-1558-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P37696.

    Family and domain databases

    Gene3Di 1.50.10.10. 1 hit.
    InterProi IPR008928. 6-hairpin_glycosidase-like.
    IPR012341. 6hp_glycosidase.
    IPR002037. Glyco_hydro_8.
    IPR019834. Glyco_hydro_8_CS.
    [Graphical view ]
    Pfami PF01270. Glyco_hydro_8. 1 hit.
    [Graphical view ]
    PRINTSi PR00735. GLHYDRLASE8.
    SUPFAMi SSF48208. SSF48208. 1 hit.
    PROSITEi PS00812. GLYCOSYL_HYDROL_F8. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new gene required for cellulose production and a gene encoding cellulolytic activity in Acetobacter xylinum are colocalized with the bcs operon."
      Standal R., Iversen T.-G., Coucheron D.H., Fjaervik E., Blatny J.M., Valla S.
      J. Bacteriol. 176:665-672(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 21-34.
      Strain: ATCC 23769 / NCIMB 8246.

    Entry informationi

    Entry nameiGUNA_KOMHA
    AccessioniPrimary (citable) accession number: P37696
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3