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Protein

Probable endoglucanase

Gene

cmcAX

Organism
Komagataeibacter hansenii (Gluconacetobacter hansenii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme capable of hydrolyzing carboxy-methyl-cellulose (CMC).

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei57Proton donorBy similarity1
Active sitei114NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH8. Glycoside Hydrolase Family 8.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endoglucanase (EC:3.2.1.4)
Alternative name(s):
Cellulase
Endo-1,4-beta-glucanase
Gene namesi
Name:cmcAX
OrganismiKomagataeibacter hansenii (Gluconacetobacter hansenii)
Taxonomic identifieri436 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeKomagataeibacter

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000000793021 – 342Probable endoglucanaseAdd BLAST322

Interactioni

Protein-protein interaction databases

STRINGi714995.GXY_04262.

Structurei

Secondary structure

1342
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 38Combined sources13
Beta strandi48 – 51Combined sources4
Beta strandi53 – 55Combined sources3
Helixi56 – 69Combined sources14
Helixi72 – 85Combined sources14
Beta strandi89 – 92Combined sources4
Beta strandi96 – 99Combined sources4
Beta strandi102 – 106Combined sources5
Helixi113 – 130Combined sources18
Helixi133 – 150Combined sources18
Beta strandi151 – 154Combined sources4
Beta strandi157 – 160Combined sources4
Beta strandi164 – 166Combined sources3
Beta strandi170 – 175Combined sources6
Helixi177 – 179Combined sources3
Helixi182 – 192Combined sources11
Helixi196 – 210Combined sources15
Turni214 – 217Combined sources4
Beta strandi221 – 226Combined sources6
Turni227 – 229Combined sources3
Beta strandi232 – 234Combined sources3
Beta strandi240 – 242Combined sources3
Turni244 – 247Combined sources4
Helixi248 – 255Combined sources8
Helixi261 – 274Combined sources14
Turni285 – 287Combined sources3
Beta strandi292 – 294Combined sources3
Helixi297 – 305Combined sources9
Helixi317 – 319Combined sources3
Helixi323 – 339Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WZZX-ray1.65A21-342[»]
ProteinModelPortaliP37696.
SMRiP37696.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37696.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105K2Z. Bacteria.
COG3405. LUCA.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR002037. Glyco_hydro_8.
IPR019834. Glyco_hydro_8_CS.
[Graphical view]
PfamiPF01270. Glyco_hydro_8. 1 hit.
[Graphical view]
PRINTSiPR00735. GLHYDRLASE8.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00812. GLYCOSYL_HYDROL_F8. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37696-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVMAAMGGA QVLSSTGAFA DPAPDAVAQQ WAIFRAKYLR PSGRVVDTGN
60 70 80 90 100
GGESHSEGQG YGMLFAASAG DLASFQSMWM WARTNLQHTN DKLFSWRFLK
110 120 130 140 150
GHQPPVPDKN NATDGDLLIA LALGRAGKRF QRPDYIQDAM AIYGDVLNLM
160 170 180 190 200
TMKAGPYVVL MPGAVGFTKK DSVILNLSYY VMPSLLQAFD LTADPRWRQV
210 220 230 240 250
MEDGIRLVSA GRFGQWRLPP DWLAVNRATG ALSIASGWPP RFSYDAIRVP
260 270 280 290 300
LYFYWAHMLA PNVLADFTRF WNNFGANALP GWVDLTTGAR SPYNAPPGYL
310 320 330 340
AVAECTGLDS AGELPTLDHA PDYYSAALTL LVYIARAEET IK
Length:342
Mass (Da):37,443
Last modified:October 1, 1994 - v1
Checksum:i85FF9BDF8B979F81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96060 Unassigned DNA. Translation: AAA16969.1.
PIRiA36963.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96060 Unassigned DNA. Translation: AAA16969.1.
PIRiA36963.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WZZX-ray1.65A21-342[»]
ProteinModelPortaliP37696.
SMRiP37696.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi714995.GXY_04262.

Protein family/group databases

CAZyiGH8. Glycoside Hydrolase Family 8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105K2Z. Bacteria.
COG3405. LUCA.

Miscellaneous databases

EvolutionaryTraceiP37696.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR002037. Glyco_hydro_8.
IPR019834. Glyco_hydro_8_CS.
[Graphical view]
PfamiPF01270. Glyco_hydro_8. 1 hit.
[Graphical view]
PRINTSiPR00735. GLHYDRLASE8.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00812. GLYCOSYL_HYDROL_F8. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUNA_KOMHA
AccessioniPrimary (citable) accession number: P37696
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.