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Protein

Probable alcohol dehydrogenase

Gene

yiaY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Fe cationBy similarity

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: CACAO
  • L-threonine 3-dehydrogenase activity Source: EcoCyc
  • metal ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, NAD

Enzyme and pathway databases

BioCyciEcoCyc:EG12293-MONOMER.
ECOL316407:JW5648-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:yiaY
Ordered Locus Names:b3589, JW5648
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12293. yiaY.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Probable alcohol dehydrogenasePRO_0000087816Add
BLAST

Proteomic databases

PaxDbiP37686.
PRIDEiP37686.

Interactioni

Protein-protein interaction databases

BioGridi4262556. 14 interactions.
DIPiDIP-12414N.
STRINGi511145.b3589.

Structurei

3D structure databases

ProteinModelPortaliP37686.
SMRiP37686. Positions 2-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C0A. Bacteria.
COG1454. LUCA.
HOGENOMiHOG000243333.
InParanoidiP37686.
KOiK13954.
OMAiIPTVNLM.
PhylomeDBiP37686.

Family and domain databases

InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]
PROSITEiPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTFFIPS VNVIGADSLT DAMNMMADYG FTRTLIVTDN MLTKLGMAGD
60 70 80 90 100
VQKALEERNI FSVIYDGTQP NPTTENVAAG LKLLKENNCD SVISLGGGSP
110 120 130 140 150
HDCAKGIALV AANGGDIRDY EGVDRSAKPQ LPMIAINTTA GTASEMTRFC
160 170 180 190 200
IITDEARHIK MAIVDKHVTP LLSVNDSSLM IGMPKSLTAA TGMDALTHAI
210 220 230 240 250
EAYVSIAATP ITDACALKAV TMIAENLPLA VEDGSNAKAR EAMAYAQFLA
260 270 280 290 300
GMAFNNASLG YVHAMAHQLG GFYNLPHGVC NAVLLPHVQV FNSKVAAARL
310 320 330 340 350
RDCAAAMGVN VTGKNDAEGA EACINAIREL AKKVDIPAGL RDLNVKEEDF
360 370 380
AVLATNALKD ACGFTNPIQA THEEIVAIYR AAM
Length:383
Mass (Da):40,351
Last modified:October 11, 2004 - v4
Checksum:i805DC4E488E108F6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti380 – 3834RAAM → AAR in AAB18566 (PubMed:8041620).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18566.1.
U00096 Genomic DNA. Translation: AAT48195.1.
AP009048 Genomic DNA. Translation: BAE77704.1.
L40742 Genomic DNA. Translation: AAC36938.1.
PIRiS47810.
RefSeqiWP_000741518.1. NZ_LN832404.1.
YP_026233.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48195; AAT48195; b3589.
BAE77704; BAE77704; BAE77704.
GeneIDi948102.
KEGGiecj:JW5648.
eco:b3589.
PATRICi32122656. VBIEscCol129921_3705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18566.1.
U00096 Genomic DNA. Translation: AAT48195.1.
AP009048 Genomic DNA. Translation: BAE77704.1.
L40742 Genomic DNA. Translation: AAC36938.1.
PIRiS47810.
RefSeqiWP_000741518.1. NZ_LN832404.1.
YP_026233.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP37686.
SMRiP37686. Positions 2-382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262556. 14 interactions.
DIPiDIP-12414N.
STRINGi511145.b3589.

Proteomic databases

PaxDbiP37686.
PRIDEiP37686.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48195; AAT48195; b3589.
BAE77704; BAE77704; BAE77704.
GeneIDi948102.
KEGGiecj:JW5648.
eco:b3589.
PATRICi32122656. VBIEscCol129921_3705.

Organism-specific databases

EchoBASEiEB2201.
EcoGeneiEG12293. yiaY.

Phylogenomic databases

eggNOGiENOG4105C0A. Bacteria.
COG1454. LUCA.
HOGENOMiHOG000243333.
InParanoidiP37686.
KOiK13954.
OMAiIPTVNLM.
PhylomeDBiP37686.

Enzyme and pathway databases

BioCyciEcoCyc:EG12293-MONOMER.
ECOL316407:JW5648-MONOMER.

Miscellaneous databases

PROiP37686.

Family and domain databases

InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]
PROSITEiPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADH2_ECOLI
AccessioniPrimary (citable) accession number: P37686
Secondary accession number(s): Q2M7Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 108 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.