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Protein

L-ribulose-5-phosphate 4-epimerase SgbE

Gene

sgbE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. May be involved in the utilization of 2,3-diketo-L-gulonate.2 Publications

Catalytic activityi

L-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi76ZincBy similarity1
Metal bindingi95ZincBy similarity1
Metal bindingi97ZincBy similarity1
Metal bindingi171ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • L-arabinose catabolic process Source: InterPro
  • L-lyxose metabolic process Source: EcoCyc
  • pentose catabolic process Source: EcoCyc

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:EG12287-MONOMER
MetaCyc:EG12287-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
L-ribulose-5-phosphate 4-epimerase SgbE (EC:5.1.3.4)
Alternative name(s):
Phosphoribulose isomerase
Gene namesi
Name:sgbE
Synonyms:yiaS
Ordered Locus Names:b3583, JW3555
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12287 sgbE

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001629231 – 231L-ribulose-5-phosphate 4-epimerase SgbEAdd BLAST231

Proteomic databases

PaxDbiP37680
PRIDEiP37680

Interactioni

Protein-protein interaction databases

BioGridi4262553, 10 interactors
IntActiP37680, 13 interactors
STRINGi316385.ECDH10B_3764

Structurei

3D structure databases

ProteinModelPortaliP37680
SMRiP37680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107R0P Bacteria
COG0235 LUCA
HOGENOMiHOG000218183
InParanoidiP37680
KOiK03077
OMAiGVEYEHM
PhylomeDBiP37680

Family and domain databases

Gene3Di3.40.225.10, 1 hit
InterProiView protein in InterPro
IPR001303 Aldolase_II/adducin_N
IPR036409 Aldolase_II/adducin_N_sf
IPR004661 AraD
PfamiView protein in Pfam
PF00596 Aldolase_II, 1 hit
SMARTiView protein in SMART
SM01007 Aldolase_II, 1 hit
SUPFAMiSSF53639 SSF53639, 1 hit
TIGRFAMsiTIGR00760 araD, 1 hit

Sequencei

Sequence statusi: Complete.

P37680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEQLKADVL AANLALPAHH LVTFTWGNVS AVDETRQWMV IKPSGVEYDV
60 70 80 90 100
MTADDMVVVE IASGKVVEGS KKPSSDTPTH LALYRRYAEI GGIVHTHSRH
110 120 130 140 150
ATIWSQAGLD LPAWGTTHAD YFYGAIPCTR QMTAEEINGE YEYQTGEVII
160 170 180 190 200
ETFEERGRSP AQIPAVLVHS HGPFAWGKNA ADAVHNAVVL EECAYMGLFS
210 220 230
RQLAPQLPAM QNELLDKHYL RKHGANAYYG Q
Length:231
Mass (Da):25,561
Last modified:October 1, 1994 - v1
Checksum:iF4FF4D7EC2A80B3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18560.1
U00096 Genomic DNA Translation: AAC76607.1
AP009048 Genomic DNA Translation: BAE77710.1
PIRiS47804
RefSeqiNP_418040.1, NC_000913.3
WP_000893142.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76607; AAC76607; b3583
BAE77710; BAE77710; BAE77710
GeneIDi948099
KEGGiecj:JW3555
eco:b3583
PATRICifig|511145.12.peg.3698

Similar proteinsi

Entry informationi

Entry nameiSGBE_ECOLI
AccessioniPrimary (citable) accession number: P37680
Secondary accession number(s): Q2M7P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health