Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-ribulose-5-phosphate 4-epimerase SgbE

Gene

sgbE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. May be involved in the utilization of 2,3-diketo-L-gulonate.2 Publications

Catalytic activityi

L-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761ZincBy similarity
Metal bindingi95 – 951ZincBy similarity
Metal bindingi97 – 971ZincBy similarity
Metal bindingi171 – 1711ZincBy similarity

GO - Molecular functioni

  1. L-ribulose-phosphate 4-epimerase activity Source: EcoCyc
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. L-arabinose catabolic process Source: InterPro
  2. L-lyxose metabolic process Source: EcoCyc
  3. pentose catabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:EG12287-MONOMER.
ECOL316407:JW3555-MONOMER.
MetaCyc:EG12287-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-ribulose-5-phosphate 4-epimerase SgbE (EC:5.1.3.4)
Alternative name(s):
Phosphoribulose isomerase
Gene namesi
Name:sgbE
Synonyms:yiaS
Ordered Locus Names:b3583, JW3555
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG12287. sgbE.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231L-ribulose-5-phosphate 4-epimerase SgbEPRO_0000162923Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP37680.

Interactioni

Protein-protein interaction databases

IntActiP37680. 13 interactions.
STRINGi511145.b3583.

Structurei

3D structure databases

ProteinModelPortaliP37680.
SMRiP37680. Positions 1-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0235.
HOGENOMiHOG000218183.
InParanoidiP37680.
KOiK03080.
OMAiIWSQAGQ.
OrthoDBiEOG6358F1.
PhylomeDBiP37680.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
InterProiIPR001303. Aldolase_II/adducin_N.
IPR004661. AraD.
[Graphical view]
PfamiPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTiSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMiSSF53639. SSF53639. 1 hit.
TIGRFAMsiTIGR00760. araD. 1 hit.

Sequencei

Sequence statusi: Complete.

P37680-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEQLKADVL AANLALPAHH LVTFTWGNVS AVDETRQWMV IKPSGVEYDV
60 70 80 90 100
MTADDMVVVE IASGKVVEGS KKPSSDTPTH LALYRRYAEI GGIVHTHSRH
110 120 130 140 150
ATIWSQAGLD LPAWGTTHAD YFYGAIPCTR QMTAEEINGE YEYQTGEVII
160 170 180 190 200
ETFEERGRSP AQIPAVLVHS HGPFAWGKNA ADAVHNAVVL EECAYMGLFS
210 220 230
RQLAPQLPAM QNELLDKHYL RKHGANAYYG Q
Length:231
Mass (Da):25,561
Last modified:October 1, 1994 - v1
Checksum:iF4FF4D7EC2A80B3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18560.1.
U00096 Genomic DNA. Translation: AAC76607.1.
AP009048 Genomic DNA. Translation: BAE77710.1.
PIRiS47804.
RefSeqiNP_418040.1. NC_000913.3.
YP_491851.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC76607; AAC76607; b3583.
BAE77710; BAE77710; BAE77710.
GeneIDi12933559.
948099.
KEGGiecj:Y75_p3592.
eco:b3583.
PATRICi32122642. VBIEscCol129921_3698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18560.1.
U00096 Genomic DNA. Translation: AAC76607.1.
AP009048 Genomic DNA. Translation: BAE77710.1.
PIRiS47804.
RefSeqiNP_418040.1. NC_000913.3.
YP_491851.1. NC_007779.1.

3D structure databases

ProteinModelPortaliP37680.
SMRiP37680. Positions 1-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP37680. 13 interactions.
STRINGi511145.b3583.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76607; AAC76607; b3583.
BAE77710; BAE77710; BAE77710.
GeneIDi12933559.
948099.
KEGGiecj:Y75_p3592.
eco:b3583.
PATRICi32122642. VBIEscCol129921_3698.

Organism-specific databases

EchoBASEiEB2195.
EcoGeneiEG12287. sgbE.

Phylogenomic databases

eggNOGiCOG0235.
HOGENOMiHOG000218183.
InParanoidiP37680.
KOiK03080.
OMAiIWSQAGQ.
OrthoDBiEOG6358F1.
PhylomeDBiP37680.

Enzyme and pathway databases

BioCyciEcoCyc:EG12287-MONOMER.
ECOL316407:JW3555-MONOMER.
MetaCyc:EG12287-MONOMER.

Miscellaneous databases

PROiP37680.

Gene expression databases

GenevestigatoriP37680.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
InterProiIPR001303. Aldolase_II/adducin_N.
IPR004661. AraD.
[Graphical view]
PfamiPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTiSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMiSSF53639. SSF53639. 1 hit.
TIGRFAMsiTIGR00760. araD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."
    Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.
    Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Novel phosphotransferases system genes revealed by bacterial genome analysis: operons encoding homologues of sugar-specific permease domains of the phosphotransferase system and pentose catabolic enzymes."
    Reizer J., Charbit A., Reizer A., Saier M.H. Jr.
    Genome Sci. Technol. 1:53-75(1996)
    Cited for: DISCUSSION OF SEQUENCE.
  5. "Role of the yiaR and yiaS genes of Escherichia coli in metabolism of endogenously formed L-xylulose."
    Ibanez E., Gimenez R., Pedraza T., Baldoma L., Aguilar J., Badia J.
    J. Bacteriol. 182:4625-4627(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons."
    Yew W.S., Gerlt J.A.
    J. Bacteriol. 184:302-306(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CHARACTERIZATION.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiSGBE_ECOLI
AccessioniPrimary (citable) accession number: P37680
Secondary accession number(s): Q2M7P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: January 7, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.