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P37680 (SGBE_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-ribulose-5-phosphate 4-epimerase SgbE

EC=5.1.3.4
Alternative name(s):
Phosphoribulose isomerase
Gene names
Name:sgbE
Synonyms:yiaS
Ordered Locus Names:b3583, JW3555
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. May be involved in the utilization of 2,3-diketo-L-gulonate. Ref.5 Ref.6

Catalytic activity

L-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactor

Binds 1 zinc ion per subunit Potential.

Sequence similarities

Belongs to the aldolase class II family. AraD/FucA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 231231L-ribulose-5-phosphate 4-epimerase SgbE
PRO_0000162923

Sites

Metal binding761Zinc By similarity
Metal binding951Zinc By similarity
Metal binding971Zinc By similarity
Metal binding1711Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
P37680 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: F4FF4D7EC2A80B3A

FASTA23125,561
        10         20         30         40         50         60 
MLEQLKADVL AANLALPAHH LVTFTWGNVS AVDETRQWMV IKPSGVEYDV MTADDMVVVE 

        70         80         90        100        110        120 
IASGKVVEGS KKPSSDTPTH LALYRRYAEI GGIVHTHSRH ATIWSQAGLD LPAWGTTHAD 

       130        140        150        160        170        180 
YFYGAIPCTR QMTAEEINGE YEYQTGEVII ETFEERGRSP AQIPAVLVHS HGPFAWGKNA 

       190        200        210        220        230 
ADAVHNAVVL EECAYMGLFS RQLAPQLPAM QNELLDKHYL RKHGANAYYG Q 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."
Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.
Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Novel phosphotransferases system genes revealed by bacterial genome analysis: operons encoding homologues of sugar-specific permease domains of the phosphotransferase system and pentose catabolic enzymes."
Reizer J., Charbit A., Reizer A., Saier M.H. Jr.
Genome Sci. Technol. 1:53-75(1996)
Cited for: DISCUSSION OF SEQUENCE.
[5]"Role of the yiaR and yiaS genes of Escherichia coli in metabolism of endogenously formed L-xylulose."
Ibanez E., Gimenez R., Pedraza T., Baldoma L., Aguilar J., Badia J.
J. Bacteriol. 182:4625-4627(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons."
Yew W.S., Gerlt J.A.
J. Bacteriol. 184:302-306(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, CHARACTERIZATION.
Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00039 Genomic DNA. Translation: AAB18560.1.
U00096 Genomic DNA. Translation: AAC76607.1.
AP009048 Genomic DNA. Translation: BAE77710.1.
PIRS47804.
RefSeqNP_418040.1. NC_000913.3.
YP_491851.1. NC_007779.1.

3D structure databases

ProteinModelPortalP37680.
SMRP37680. Positions 1-223.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP37680. 13 interactions.
STRING511145.b3583.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC76607; AAC76607; b3583.
BAE77710; BAE77710; BAE77710.
GeneID12933559.
948099.
KEGGecj:Y75_p3592.
eco:b3583.
PATRIC32122642. VBIEscCol129921_3698.

Organism-specific databases

EchoBASEEB2195.
EcoGeneEG12287. sgbE.

Phylogenomic databases

eggNOGCOG0235.
HOGENOMHOG000218183.
KOK03080.
OMASGVEYEH.
OrthoDBEOG6358F1.
PhylomeDBP37680.
ProtClustDBPRK12347.

Enzyme and pathway databases

BioCycEcoCyc:EG12287-MONOMER.
ECOL316407:JW3555-MONOMER.
MetaCyc:EG12287-MONOMER.

Gene expression databases

GenevestigatorP37680.

Family and domain databases

Gene3D3.40.225.10. 1 hit.
InterProIPR001303. Aldolase_II/adducin_N.
IPR004661. AraD.
[Graphical view]
PfamPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMSSF53639. SSF53639. 1 hit.
TIGRFAMsTIGR00760. araD. 1 hit.
ProtoNetSearch...

Other

PROP37680.

Entry information

Entry nameSGBE_ECOLI
AccessionPrimary (citable) accession number: P37680
Secondary accession number(s): Q2M7P6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene