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P37680

- SGBE_ECOLI

UniProt

P37680 - SGBE_ECOLI

Protein

L-ribulose-5-phosphate 4-epimerase SgbE

Gene

sgbE

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. May be involved in the utilization of 2,3-diketo-L-gulonate.2 Publications

    Catalytic activityi

    L-ribulose 5-phosphate = D-xylulose 5-phosphate.

    Cofactori

    Binds 1 zinc ion per subunit.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi76 – 761ZincBy similarity
    Metal bindingi95 – 951ZincBy similarity
    Metal bindingi97 – 971ZincBy similarity
    Metal bindingi171 – 1711ZincBy similarity

    GO - Molecular functioni

    1. L-ribulose-phosphate 4-epimerase activity Source: EcoCyc
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. L-arabinose catabolic process Source: InterPro
    2. L-lyxose metabolic process Source: EcoCyc
    3. pentose catabolic process Source: EcoCyc

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciEcoCyc:EG12287-MONOMER.
    ECOL316407:JW3555-MONOMER.
    MetaCyc:EG12287-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-ribulose-5-phosphate 4-epimerase SgbE (EC:5.1.3.4)
    Alternative name(s):
    Phosphoribulose isomerase
    Gene namesi
    Name:sgbE
    Synonyms:yiaS
    Ordered Locus Names:b3583, JW3555
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG12287. sgbE.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 231231L-ribulose-5-phosphate 4-epimerase SgbEPRO_0000162923Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP37680.

    Interactioni

    Protein-protein interaction databases

    IntActiP37680. 13 interactions.
    STRINGi511145.b3583.

    Structurei

    3D structure databases

    ProteinModelPortaliP37680.
    SMRiP37680. Positions 1-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0235.
    HOGENOMiHOG000218183.
    KOiK03080.
    OMAiSGVEYEH.
    OrthoDBiEOG6358F1.
    PhylomeDBiP37680.

    Family and domain databases

    Gene3Di3.40.225.10. 1 hit.
    InterProiIPR001303. Aldolase_II/adducin_N.
    IPR004661. AraD.
    [Graphical view]
    PfamiPF00596. Aldolase_II. 1 hit.
    [Graphical view]
    SMARTiSM01007. Aldolase_II. 1 hit.
    [Graphical view]
    SUPFAMiSSF53639. SSF53639. 1 hit.
    TIGRFAMsiTIGR00760. araD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P37680-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLEQLKADVL AANLALPAHH LVTFTWGNVS AVDETRQWMV IKPSGVEYDV    50
    MTADDMVVVE IASGKVVEGS KKPSSDTPTH LALYRRYAEI GGIVHTHSRH 100
    ATIWSQAGLD LPAWGTTHAD YFYGAIPCTR QMTAEEINGE YEYQTGEVII 150
    ETFEERGRSP AQIPAVLVHS HGPFAWGKNA ADAVHNAVVL EECAYMGLFS 200
    RQLAPQLPAM QNELLDKHYL RKHGANAYYG Q 231
    Length:231
    Mass (Da):25,561
    Last modified:October 1, 1994 - v1
    Checksum:iF4FF4D7EC2A80B3A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00039 Genomic DNA. Translation: AAB18560.1.
    U00096 Genomic DNA. Translation: AAC76607.1.
    AP009048 Genomic DNA. Translation: BAE77710.1.
    PIRiS47804.
    RefSeqiNP_418040.1. NC_000913.3.
    YP_491851.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC76607; AAC76607; b3583.
    BAE77710; BAE77710; BAE77710.
    GeneIDi12933559.
    948099.
    KEGGiecj:Y75_p3592.
    eco:b3583.
    PATRICi32122642. VBIEscCol129921_3698.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00039 Genomic DNA. Translation: AAB18560.1 .
    U00096 Genomic DNA. Translation: AAC76607.1 .
    AP009048 Genomic DNA. Translation: BAE77710.1 .
    PIRi S47804.
    RefSeqi NP_418040.1. NC_000913.3.
    YP_491851.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P37680.
    SMRi P37680. Positions 1-223.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P37680. 13 interactions.
    STRINGi 511145.b3583.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC76607 ; AAC76607 ; b3583 .
    BAE77710 ; BAE77710 ; BAE77710 .
    GeneIDi 12933559.
    948099.
    KEGGi ecj:Y75_p3592.
    eco:b3583.
    PATRICi 32122642. VBIEscCol129921_3698.

    Organism-specific databases

    EchoBASEi EB2195.
    EcoGenei EG12287. sgbE.

    Phylogenomic databases

    eggNOGi COG0235.
    HOGENOMi HOG000218183.
    KOi K03080.
    OMAi SGVEYEH.
    OrthoDBi EOG6358F1.
    PhylomeDBi P37680.

    Enzyme and pathway databases

    BioCyci EcoCyc:EG12287-MONOMER.
    ECOL316407:JW3555-MONOMER.
    MetaCyc:EG12287-MONOMER.

    Miscellaneous databases

    PROi P37680.

    Gene expression databases

    Genevestigatori P37680.

    Family and domain databases

    Gene3Di 3.40.225.10. 1 hit.
    InterProi IPR001303. Aldolase_II/adducin_N.
    IPR004661. AraD.
    [Graphical view ]
    Pfami PF00596. Aldolase_II. 1 hit.
    [Graphical view ]
    SMARTi SM01007. Aldolase_II. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53639. SSF53639. 1 hit.
    TIGRFAMsi TIGR00760. araD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."
      Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.
      Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "Novel phosphotransferases system genes revealed by bacterial genome analysis: operons encoding homologues of sugar-specific permease domains of the phosphotransferase system and pentose catabolic enzymes."
      Reizer J., Charbit A., Reizer A., Saier M.H. Jr.
      Genome Sci. Technol. 1:53-75(1996)
      Cited for: DISCUSSION OF SEQUENCE.
    5. "Role of the yiaR and yiaS genes of Escherichia coli in metabolism of endogenously formed L-xylulose."
      Ibanez E., Gimenez R., Pedraza T., Baldoma L., Aguilar J., Badia J.
      J. Bacteriol. 182:4625-4627(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons."
      Yew W.S., Gerlt J.A.
      J. Bacteriol. 184:302-306(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CHARACTERIZATION.
      Strain: K12 / MG1655 / ATCC 47076.

    Entry informationi

    Entry nameiSGBE_ECOLI
    AccessioniPrimary (citable) accession number: P37680
    Secondary accession number(s): Q2M7P6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3