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Protein

3-keto-L-gulonate-6-phosphate decarboxylase SgbH

Gene

sgbH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. May be involved in the utilization of 2,3-diketo-L-gulonate.1 Publication

Catalytic activityi

3-dehydro-L-gulonate 6-phosphate = L-xylulose 5-phosphate + CO2.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111SubstrateBy similarity
Metal bindingi33 – 331MagnesiumBy similarity
Metal bindingi62 – 621MagnesiumBy similarity
Sitei64 – 641Transition state stabilizerBy similarity
Sitei67 – 671Transition state stabilizerBy similarity
Binding sitei192 – 1921SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12285-MONOMER.
ECOL316407:JW3553-MONOMER.
MetaCyc:EG12285-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3-keto-L-gulonate-6-phosphate decarboxylase SgbH (EC:4.1.1.85)
Short name:
KGPDC
Alternative name(s):
3-dehydro-L-gulonate-6-phosphate decarboxylase
Gene namesi
Name:sgbH
Synonyms:yiaQ
Ordered Locus Names:b3581, JW3553
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12285. sgbH.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2202203-keto-L-gulonate-6-phosphate decarboxylase SgbHPRO_0000212105Add
BLAST

Proteomic databases

PaxDbiP37678.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi4259346. 191 interactions.
DIPiDIP-10873N.
IntActiP37678. 3 interactions.
MINTiMINT-1281843.
STRINGi511145.b3581.

Structurei

3D structure databases

ProteinModelPortaliP37678.
SMRiP37678. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HPS/KGPDC family. KGPDC subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105H6Q. Bacteria.
COG0269. LUCA.
HOGENOMiHOG000226068.
InParanoidiP37678.
KOiK03081.
OMAiCISAGIQ.
OrthoDBiEOG66B435.
PhylomeDBiP37678.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

P37678-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPLLQLAL DHSSLEAAQR DVTLLKDSVD IVEAGTILCL NEGLGAVKAL
60 70 80 90 100
REQCPDKIIV ADWKVADAGE TLAQQAFGAG ANWMTIICAA PLATVEKGHA
110 120 130 140 150
MAQRCGGEIQ IELFGNWTLD DARDWHRIGV RQAIYHRGRD AQASGQQWGE
160 170 180 190 200
ADLARMKALS DIGLELSITG GITPADLPLF KDIRVKAFIA GRALAGAANP
210 220
AQVAGDFHAQ IDAIWGGARA
Length:220
Mass (Da):23,445
Last modified:October 1, 1994 - v1
Checksum:i89465A10F6AECD87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18558.1.
U00096 Genomic DNA. Translation: AAC76605.1.
AP009048 Genomic DNA. Translation: BAE77712.1.
PIRiS47802.
RefSeqiNP_418038.1. NC_000913.3.
WP_000089481.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76605; AAC76605; b3581.
BAE77712; BAE77712; BAE77712.
GeneIDi948098.
KEGGiecj:JW3553.
eco:b3581.
PATRICi32122638. VBIEscCol129921_3696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18558.1.
U00096 Genomic DNA. Translation: AAC76605.1.
AP009048 Genomic DNA. Translation: BAE77712.1.
PIRiS47802.
RefSeqiNP_418038.1. NC_000913.3.
WP_000089481.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37678.
SMRiP37678. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259346. 191 interactions.
DIPiDIP-10873N.
IntActiP37678. 3 interactions.
MINTiMINT-1281843.
STRINGi511145.b3581.

Proteomic databases

PaxDbiP37678.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76605; AAC76605; b3581.
BAE77712; BAE77712; BAE77712.
GeneIDi948098.
KEGGiecj:JW3553.
eco:b3581.
PATRICi32122638. VBIEscCol129921_3696.

Organism-specific databases

EchoBASEiEB2193.
EcoGeneiEG12285. sgbH.

Phylogenomic databases

eggNOGiENOG4105H6Q. Bacteria.
COG0269. LUCA.
HOGENOMiHOG000226068.
InParanoidiP37678.
KOiK03081.
OMAiCISAGIQ.
OrthoDBiEOG66B435.
PhylomeDBiP37678.

Enzyme and pathway databases

BioCyciEcoCyc:EG12285-MONOMER.
ECOL316407:JW3553-MONOMER.
MetaCyc:EG12285-MONOMER.

Miscellaneous databases

PROiP37678.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."
    Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.
    Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Novel phosphotransferases system genes revealed by bacterial genome analysis: operons encoding homologues of sugar-specific permease domains of the phosphotransferase system and pentose catabolic enzymes."
    Reizer J., Charbit A., Reizer A., Saier M.H. Jr.
    Genome Sci. Technol. 1:53-75(1996)
    Cited for: DISCUSSION OF SEQUENCE.
  5. "Is the ribulose monophosphate pathway widely distributed in bacteria?"
    Reizer J., Reizer A., Saier M.H. Jr.
    Microbiology 143:2519-2520(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.
  6. "Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons."
    Yew W.S., Gerlt J.A.
    J. Bacteriol. 184:302-306(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiSGBH_ECOLI
AccessioniPrimary (citable) accession number: P37678
Secondary accession number(s): Q2M7P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 6, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.