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Protein

3-keto-L-gulonate-6-phosphate decarboxylase SgbH

Gene

sgbH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. May be involved in the utilization of 2,3-diketo-L-gulonate.1 Publication

Catalytic activityi

3-dehydro-L-gulonate 6-phosphate = L-xylulose 5-phosphate + CO2.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11SubstrateBy similarity1
Metal bindingi33MagnesiumBy similarity1
Metal bindingi62MagnesiumBy similarity1
Sitei64Transition state stabilizerBy similarity1
Sitei67Transition state stabilizerBy similarity1
Binding sitei192SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processCarbohydrate metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12285-MONOMER
MetaCyc:EG12285-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
3-keto-L-gulonate-6-phosphate decarboxylase SgbH (EC:4.1.1.85)
Short name:
KGPDC
Alternative name(s):
3-dehydro-L-gulonate-6-phosphate decarboxylase
Gene namesi
Name:sgbH
Synonyms:yiaQ
Ordered Locus Names:b3581, JW3553
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12285 sgbH

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002121051 – 2203-keto-L-gulonate-6-phosphate decarboxylase SgbHAdd BLAST220

Proteomic databases

PaxDbiP37678
PRIDEiP37678

Interactioni

Subunit structurei

Homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
nudFQ93K972EBI-555448,EBI-562814

Protein-protein interaction databases

BioGridi4259346, 191 interactors
DIPiDIP-10873N
IntActiP37678, 3 interactors
STRINGi316385.ECDH10B_3762

Structurei

3D structure databases

ProteinModelPortaliP37678
SMRiP37678
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HPS/KGPDC family. KGPDC subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105H6Q Bacteria
COG0269 LUCA
HOGENOMiHOG000226068
InParanoidiP37678
KOiK03078
OMAiVICAAPL
PhylomeDBiP37678

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

P37678-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPLLQLAL DHSSLEAAQR DVTLLKDSVD IVEAGTILCL NEGLGAVKAL
60 70 80 90 100
REQCPDKIIV ADWKVADAGE TLAQQAFGAG ANWMTIICAA PLATVEKGHA
110 120 130 140 150
MAQRCGGEIQ IELFGNWTLD DARDWHRIGV RQAIYHRGRD AQASGQQWGE
160 170 180 190 200
ADLARMKALS DIGLELSITG GITPADLPLF KDIRVKAFIA GRALAGAANP
210 220
AQVAGDFHAQ IDAIWGGARA
Length:220
Mass (Da):23,445
Last modified:October 1, 1994 - v1
Checksum:i89465A10F6AECD87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18558.1
U00096 Genomic DNA Translation: AAC76605.1
AP009048 Genomic DNA Translation: BAE77712.1
PIRiS47802
RefSeqiNP_418038.1, NC_000913.3
WP_000089481.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76605; AAC76605; b3581
BAE77712; BAE77712; BAE77712
GeneIDi948098
KEGGiecj:JW3553
eco:b3581
PATRICifig|511145.12.peg.3696

Similar proteinsi

Entry informationi

Entry nameiSGBH_ECOLI
AccessioniPrimary (citable) accession number: P37678
Secondary accession number(s): Q2M7P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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