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P37677

- LYXK_ECOLI

UniProt

P37677 - LYXK_ECOLI

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Protein
L-xylulose/3-keto-L-gulonate kinase
Gene
lyx, lyxK, sgbK, xylK, yiaP, b3580, JW3552
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of L-xylulose and 3-keto-L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate.2 Publications

Catalytic activityi

ATP + L-xylulose = ADP + L-xylulose 5-phosphate.
ATP + 3-dehydro-L-gulonate = ADP + 3-dehydro-L-gulonate 6-phosphate.

Kineticsi

  1. KM=0.8 mM for L-xylulose1 Publication
  2. KM=0.4 mM for ATP

Vmax=33 µmol/min/mg enzyme with L-xylulose as substrate

pH dependencei

Optimum pH is 8.4 with L-xylulose as substrate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. L-xylulokinase activity Source: EcoCyc

GO - Biological processi

  1. L-lyxose metabolic process Source: EcoCyc
  2. carbohydrate phosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:LYXK-MONOMER.
ECOL316407:JW3552-MONOMER.
MetaCyc:LYXK-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-xylulose/3-keto-L-gulonate kinase (EC:2.7.1.-, EC:2.7.1.53)
Short name:
L-xylulokinase
Alternative name(s):
3-dehydro-L-gulonate kinase
Gene namesi
Name:lyx
Synonyms:lyxK, sgbK, xylK, yiaP
Ordered Locus Names:b3580, JW3552
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG12284. lyx.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498L-xylulose/3-keto-L-gulonate kinase
PRO_0000059560Add
BLAST

Proteomic databases

PRIDEiP37677.

Expressioni

Gene expression databases

GenevestigatoriP37677.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiP37677. 2 interactions.
STRINGi511145.b3580.

Structurei

3D structure databases

ProteinModelPortaliP37677.
SMRiP37677. Positions 6-492.

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG1070.
HOGENOMiHOG000222135.
KOiK00880.
OMAiQVCAEVV.
OrthoDBiEOG6KDKMT.
PhylomeDBiP37677.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PROSITEiPS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37677-1 [UniParc]FASTAAdd to Basket

« Hide

MTQYWLGLDC GGSWLKAGLY DREGREAGVQ RLPLCALSPQ PGWAERDMAE    50
LWQCCMAVIR ALLTHSGVSG EQIVGIGISA QGKGLFLLDK NDKPLGNAIL 100
SSDRRAMEIV RRWQEDGIPE KLYPLTRQTL WTGHPVSLLR WLKEHEPERY 150
AQIGCVMMTH DYLRWCLTGV KGCEESNISE SNLYNMSLGE YDPCLTDWLG 200
IAEINHALPP VVGSAEICGE ITAQTAALTG LKAGTPVVGG LFDVVSTALC 250
AGIEDEFTLN AVMGTWAVTS GITRGLRDGE AHPYVYGRYV NDGEFIVHEA 300
SPTSSGNLEW FTAQWGEISF DEINQAVASL PKAGGDLFFL PFLYGSNAGL 350
EMTSGFYGMQ AIHTRAHLLQ AIYEGVVFSH MTHLNRMRER FTDVHTLRVT 400
GGPAHSDVWM QMLADVSGLR IELPQVEETG CFGAALAARV GTGVYHNFSE 450
AQRDLRHPVR TLLPDMTAHQ LYQKKYQRYQ HLIAALQGFH ARIKEHTL 498
Length:498
Mass (Da):55,155
Last modified:October 1, 1994 - v1
Checksum:i207EC94507141E34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00039 Genomic DNA. Translation: AAB18557.1.
U00096 Genomic DNA. Translation: AAC76604.1.
AP009048 Genomic DNA. Translation: BAE77713.1.
PIRiS47801.
RefSeqiNP_418037.1. NC_000913.3.
YP_491854.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC76604; AAC76604; b3580.
BAE77713; BAE77713; BAE77713.
GeneIDi12933556.
948101.
KEGGiecj:Y75_p3595.
eco:b3580.
PATRICi32122636. VBIEscCol129921_3695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00039 Genomic DNA. Translation: AAB18557.1 .
U00096 Genomic DNA. Translation: AAC76604.1 .
AP009048 Genomic DNA. Translation: BAE77713.1 .
PIRi S47801.
RefSeqi NP_418037.1. NC_000913.3.
YP_491854.1. NC_007779.1.

3D structure databases

ProteinModelPortali P37677.
SMRi P37677. Positions 6-492.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P37677. 2 interactions.
STRINGi 511145.b3580.

Proteomic databases

PRIDEi P37677.

Protocols and materials databases

DNASUi 948101.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC76604 ; AAC76604 ; b3580 .
BAE77713 ; BAE77713 ; BAE77713 .
GeneIDi 12933556.
948101.
KEGGi ecj:Y75_p3595.
eco:b3580.
PATRICi 32122636. VBIEscCol129921_3695.

Organism-specific databases

EchoBASEi EB2192.
EcoGenei EG12284. lyx.

Phylogenomic databases

eggNOGi COG1070.
HOGENOMi HOG000222135.
KOi K00880.
OMAi QVCAEVV.
OrthoDBi EOG6KDKMT.
PhylomeDBi P37677.

Enzyme and pathway databases

BioCyci EcoCyc:LYXK-MONOMER.
ECOL316407:JW3552-MONOMER.
MetaCyc:LYXK-MONOMER.

Miscellaneous databases

PROi P37677.

Gene expression databases

Genevestigatori P37677.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
PROSITEi PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."
    Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.
    Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Activation of a cryptic gene encoding a kinase for L-xylulose opens a new pathway for the utilization of L-lyxose by Escherichia coli."
    Sanchez J.C., Gimenez R., Schneider A., Fessner W.-D., Baldoma L., Aquilar J., Badia J.
    J. Biol. Chem. 269:29665-29669(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, BIOPHYSICOCHEMICAL PROPERTIES.
    Strain: K12.
  5. "Novel phosphotransferases system genes revealed by bacterial genome analysis: operons encoding homologues of sugar-specific permease domains of the phosphotransferase system and pentose catabolic enzymes."
    Reizer J., Charbit A., Reizer A., Saier M.H. Jr.
    Genome Sci. Technol. 1:53-75(1996)
    Cited for: DISCUSSION OF SEQUENCE.
  6. "Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons."
    Yew W.S., Gerlt J.A.
    J. Bacteriol. 184:302-306(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiLYXK_ECOLI
AccessioniPrimary (citable) accession number: P37677
Secondary accession number(s): Q2M7P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 14, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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