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Protein

2,3-diketo-L-gulonate TRAP transporter large permease protein YiaN

Gene

yiaN

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L-gulonate.1 Publication

GO - Molecular functioni

  • substrate-specific transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • carbohydrate transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG12282-MONOMER.
ECOL316407:JW5651-MONOMER.
MetaCyc:EG12282-MONOMER.

Protein family/group databases

TCDBi2.A.56.1.2. the tripartite atp-independent periplasmic transporter (trap-t) family.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-diketo-L-gulonate TRAP transporter large permease protein YiaN
Gene namesi
Name:yiaN
Ordered Locus Names:b3578, JW5651
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12282. yiaN.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001695981 – 4252,3-diketo-L-gulonate TRAP transporter large permease protein YiaNAdd BLAST425

Proteomic databases

PaxDbiP37675.
PRIDEiP37675.

Interactioni

Subunit structurei

The complex comprises the extracytoplasmic solute receptor protein YiaO, and the two transmembrane proteins YiaM and YiaN.

Protein-protein interaction databases

BioGridi4262549. 9 interactors.
STRINGi511145.b3578.

Structurei

3D structure databases

ProteinModelPortaliP37675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CG6. Bacteria.
COG1593. LUCA.
HOGENOMiHOG000266922.
InParanoidiP37675.
OMAiIHRELNC.
PhylomeDBiP37675.

Family and domain databases

InterProiIPR010656. DctM.
IPR004681. TRAP_transpt_permease.
[Graphical view]
PfamiPF06808. DctM. 1 hit.
[Graphical view]
PIRSFiPIRSF006066. HI0050. 1 hit.
TIGRFAMsiTIGR00786. dctM. 1 hit.

Sequencei

Sequence statusi: Complete.

P37675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLIFLGCL LGGIAIGLPI AWALLLCGAA LMFWLDMFDV QIMAQTLVNG
60 70 80 90 100
ADSFSLLAIP FFVLAGEIMN AGGLSKRIVD LPMKLVGHKP GGLGYVGVLA
110 120 130 140 150
AMIMASLSGS AVADTAAVAA LLVPMMRSAN YPVNRAAGLI ASGGIIAPII
160 170 180 190 200
PPSIPFIIFG VSSGLSISKL FMAGIAPGMM MGATLMLTWW WQASRLNLPR
210 220 230 240 250
QQKATMQEIW HSFVSGIWAL FLPVIIIGGF RSGLFTPTEA GAVAAFYALF
260 270 280 290 300
VATVIYREMT FATLWHVLIG AAKTTSVVMF LVASAQVSAW LITIAELPMM
310 320 330 340 350
VSDLLQPLVD SPRLLFIVIM VAILIVGMVM DLTPTVLILT PVLMPLVKEA
360 370 380 390 400
GIDPIYFGVM FIINCSIGLI TPPIGNVLNV ISGVAKLKFD DAVRGVFPYV
410 420
LVLYSLLVVF VFIPDLIILP LKWIN
Length:425
Mass (Da):45,368
Last modified:October 11, 2004 - v2
Checksum:i4A90B9E035B1C98A
GO

Sequence cautioni

The sequence AAB18555 differs from that shown. Reason: Frameshift at position 391.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18555.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48194.1.
AP009048 Genomic DNA. Translation: BAE77715.1.
PIRiS47799.
RefSeqiWP_000279599.1. NZ_LN832404.1.
YP_026232.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48194; AAT48194; b3578.
BAE77715; BAE77715; BAE77715.
GeneIDi948092.
KEGGiecj:JW5651.
eco:b3578.
PATRICi32122632. VBIEscCol129921_3693.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18555.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48194.1.
AP009048 Genomic DNA. Translation: BAE77715.1.
PIRiS47799.
RefSeqiWP_000279599.1. NZ_LN832404.1.
YP_026232.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP37675.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262549. 9 interactors.
STRINGi511145.b3578.

Protein family/group databases

TCDBi2.A.56.1.2. the tripartite atp-independent periplasmic transporter (trap-t) family.

Proteomic databases

PaxDbiP37675.
PRIDEiP37675.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48194; AAT48194; b3578.
BAE77715; BAE77715; BAE77715.
GeneIDi948092.
KEGGiecj:JW5651.
eco:b3578.
PATRICi32122632. VBIEscCol129921_3693.

Organism-specific databases

EchoBASEiEB2190.
EcoGeneiEG12282. yiaN.

Phylogenomic databases

eggNOGiENOG4105CG6. Bacteria.
COG1593. LUCA.
HOGENOMiHOG000266922.
InParanoidiP37675.
OMAiIHRELNC.
PhylomeDBiP37675.

Enzyme and pathway databases

BioCyciEcoCyc:EG12282-MONOMER.
ECOL316407:JW5651-MONOMER.
MetaCyc:EG12282-MONOMER.

Miscellaneous databases

PROiP37675.

Family and domain databases

InterProiIPR010656. DctM.
IPR004681. TRAP_transpt_permease.
[Graphical view]
PfamiPF06808. DctM. 1 hit.
[Graphical view]
PIRSFiPIRSF006066. HI0050. 1 hit.
TIGRFAMsiTIGR00786. dctM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYIAN_ECOLI
AccessioniPrimary (citable) accession number: P37675
Secondary accession number(s): Q2M7P1, Q6BF20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally proposed to be a subunit from an L-xylulose uptake system, but PubMed:16385129 shows that it does not bind L- or D-xylulose.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.