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Protein

2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM

Gene

yiaM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L-gulonate.1 Publication

GO - Molecular functioni

  • carbohydrate transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • carbohydrate transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-422.
ECOL316407:JW3549-MONOMER.
MetaCyc:MONOMER0-422.

Protein family/group databases

TCDBi2.A.56.1.2. the tripartite atp-independent periplasmic transporter (trap-t) family.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM
Gene namesi
Name:yiaM
Ordered Locus Names:b3577, JW3549
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12281. yiaM.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence analysis
Transmembranei7 – 2923HelicalSequence analysisAdd
BLAST
Topological domaini30 – 4314PeriplasmicSequence analysisAdd
BLAST
Transmembranei44 – 6623HelicalSequence analysisAdd
BLAST
Topological domaini67 – 7812CytoplasmicSequence analysisAdd
BLAST
Transmembranei79 – 9820HelicalSequence analysisAdd
BLAST
Topological domaini99 – 11214PeriplasmicSequence analysisAdd
BLAST
Transmembranei113 – 13523HelicalSequence analysisAdd
BLAST
Topological domaini136 – 15722CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1571572,3-diketo-L-gulonate TRAP transporter small permease protein YiaMPRO_0000169595Add
BLAST

Proteomic databases

PaxDbiP37674.

Interactioni

Subunit structurei

The complex comprises the extracytoplasmic solute receptor protein YiaO, and the two transmembrane proteins YiaM and YiaN.

Protein-protein interaction databases

BioGridi4262548. 5 interactions.
STRINGi511145.b3577.

Structurei

3D structure databases

ProteinModelPortaliP37674.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105XDZ. Bacteria.
COG3090. LUCA.
HOGENOMiHOG000224991.
InParanoidiP37674.
OMAiMLFCCYL.
PhylomeDBiP37674.

Family and domain databases

InterProiIPR007387. DctQ_transporter.
[Graphical view]
PfamiPF04290. DctQ. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37674-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKILEAILA INLAVLSCIV FINIILRYGF QTSILSVDEL SRYLFVWLTF
60 70 80 90 100
IGAIVAFMDN AHVQVTFLVE KLSPAWQRRV ALVTHSLILF ICGALAWGAT
110 120 130 140 150
LKTIQDWSDY SPILGLPIGL MYAACLPTSL VIAFFELRHL YQLITRSNSL

TSPPQGA
Length:157
Mass (Da):17,516
Last modified:October 1, 1994 - v1
Checksum:iE8839A3FCEB2BEDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18554.1.
U00096 Genomic DNA. Translation: AAC76601.1.
AP009048 Genomic DNA. Translation: BAE77716.1.
PIRiS47798.
RefSeqiNP_418034.1. NC_000913.3.
WP_000721664.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76601; AAC76601; b3577.
BAE77716; BAE77716; BAE77716.
GeneIDi948093.
KEGGiecj:JW3549.
eco:b3577.
PATRICi32122630. VBIEscCol129921_3692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18554.1.
U00096 Genomic DNA. Translation: AAC76601.1.
AP009048 Genomic DNA. Translation: BAE77716.1.
PIRiS47798.
RefSeqiNP_418034.1. NC_000913.3.
WP_000721664.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37674.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262548. 5 interactions.
STRINGi511145.b3577.

Protein family/group databases

TCDBi2.A.56.1.2. the tripartite atp-independent periplasmic transporter (trap-t) family.

Proteomic databases

PaxDbiP37674.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76601; AAC76601; b3577.
BAE77716; BAE77716; BAE77716.
GeneIDi948093.
KEGGiecj:JW3549.
eco:b3577.
PATRICi32122630. VBIEscCol129921_3692.

Organism-specific databases

EchoBASEiEB2189.
EcoGeneiEG12281. yiaM.

Phylogenomic databases

eggNOGiENOG4105XDZ. Bacteria.
COG3090. LUCA.
HOGENOMiHOG000224991.
InParanoidiP37674.
OMAiMLFCCYL.
PhylomeDBiP37674.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-422.
ECOL316407:JW3549-MONOMER.
MetaCyc:MONOMER0-422.

Miscellaneous databases

PROiP37674.

Family and domain databases

InterProiIPR007387. DctQ_transporter.
[Graphical view]
PfamiPF04290. DctQ. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYIAM_ECOLI
AccessioniPrimary (citable) accession number: P37674
Secondary accession number(s): Q2M7P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally proposed to be a subunit from an L-xylulose uptake system, but PubMed:16385129 shows that it does not bind L- or D-xylulose.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.