Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

O-acetyltransferase WecH

Gene

wecH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units. Catalyzes the acetylation of both cyclic ECA (ECA(CYC)) and phosphoglyceride-linked ECA (ECA(PG)).1 Publication

Pathwayi: enterobacterial common antigen biosynthesis

This protein is involved in the pathway enterobacterial common antigen biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation1 Publication
View all proteins of this organism that are known to be involved in the pathway enterobacterial common antigen biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

  • O-acetyltransferase activity Source: EcoliWiki

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciEcoCyc:EG12274-MONOMER
BRENDAi3.1.8.1 2165
UniPathwayiUPA00566

Protein family/group databases

TCDBi9.B.97.1.1 the acyltransferase-3/putative acetyl-coa transporter (atat) family

Names & Taxonomyi

Protein namesi
Recommended name:
O-acetyltransferase WecH1 PublicationUniRule annotation (EC:2.3.1.-UniRule annotation1 Publication)
Gene namesi
Name:wecH1 PublicationUniRule annotation
Synonyms:yiaH
Ordered Locus Names:b3561, JW3533
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12274 wecH

Subcellular locationi

  • Cell inner membrane UniRule annotation1 Publication; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicCuratedAdd BLAST12
Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Topological domaini34 – 45PeriplasmicCuratedAdd BLAST12
Transmembranei46 – 66HelicalUniRule annotationAdd BLAST21
Topological domaini67 – 78CytoplasmicCuratedAdd BLAST12
Transmembranei79 – 99HelicalUniRule annotationAdd BLAST21
Topological domaini100 – 113PeriplasmicCuratedAdd BLAST14
Transmembranei114 – 134HelicalUniRule annotationAdd BLAST21
Topological domaini135 – 138CytoplasmicCurated4
Transmembranei139 – 159HelicalUniRule annotationAdd BLAST21
Topological domaini160 – 168PeriplasmicCurated9
Transmembranei169 – 189HelicalUniRule annotationAdd BLAST21
Topological domaini190 – 202CytoplasmicCuratedAdd BLAST13
Transmembranei203 – 223HelicalUniRule annotationAdd BLAST21
Topological domaini224 – 234PeriplasmicCuratedAdd BLAST11
Transmembranei235 – 255HelicalUniRule annotationAdd BLAST21
Topological domaini256 – 266CytoplasmicCuratedAdd BLAST11
Transmembranei267 – 287HelicalUniRule annotationAdd BLAST21
Topological domaini288 – 299PeriplasmicCuratedAdd BLAST12
Transmembranei300 – 320HelicalUniRule annotationAdd BLAST21
Topological domaini321 – 331Cytoplasmic1 PublicationAdd BLAST11

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant is defective in the incorporation of O-acetyl groups into both ECA(CYC) and ECA(PG).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002080981 – 331O-acetyltransferase WecHAdd BLAST331

Proteomic databases

PaxDbiP37669
PRIDEiP37669

Interactioni

Protein-protein interaction databases

BioGridi4262152, 1 interactor
DIPiDIP-12403N
IntActiP37669, 1 interactor
STRINGi316385.ECDH10B_3742

Structurei

3D structure databases

ProteinModelPortaliP37669
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyltransferase 3 family.UniRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105MEV Bacteria
COG3274 LUCA
HOGENOMiHOG000126046
OMAiTFYYVLY

Family and domain databases

HAMAPiMF_01949 Acetyltr_WecH, 1 hit
InterProiView protein in InterPro
IPR002656 Acyl_transf_3
IPR032905 WecH
PfamiView protein in Pfam
PF01757 Acyl_transf_3, 1 hit

Sequencei

Sequence statusi: Complete.

P37669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPKIYWIDN LRGIACLMVV MIHTTTWYVT NAHSVSPVTW DIANVLNSAS
60 70 80 90 100
RVSVPLFFMI SGYLFFGERS AQPRHFLRIG LCLIFYSAIA LLYIALFTSI
110 120 130 140 150
NMELALKNLL QKPVFYHLWF FFAIAVIYLV SPLIQVKNVG GKMLLVLMAV
160 170 180 190 200
IGIIANPNTV PQKIDGFEWL PINLYINGDT FYYILYGMLG RAIGMMDTQH
210 220 230 240 250
KALSWVSAAL FATGVFIISR GTLYELQWRG NFADTWYLYC GPMVFICAIA
260 270 280 290 300
LLTLVKNTLD TRTIRGLGLI SRHSLGIYGF HALIIHALRT RGIELKNWPI
310 320 330
LDIIWIFCAT LAASLLLSML VQRIDRNRLV S
Length:331
Mass (Da):37,570
Last modified:October 1, 1994 - v1
Checksum:i88FD5A182110F63C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18538.1
U00096 Genomic DNA Translation: AAC76585.1
AP009048 Genomic DNA Translation: BAE77732.1
PIRiS47782
RefSeqiNP_418018.1, NC_000913.3
WP_001182650.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76585; AAC76585; b3561
BAE77732; BAE77732; BAE77732
GeneIDi948077
KEGGiecj:JW3533
eco:b3561
PATRICifig|1411691.4.peg.3151

Similar proteinsi

Entry informationi

Entry nameiWECH_ECOLI
AccessioniPrimary (citable) accession number: P37669
Secondary accession number(s): Q2M7M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health