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Protein

Putative cellulose biosynthesis protein BcsQ

Gene

bcsQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein uncertaini

Functioni

Essential for cellulose biosynthesis. May play a role in subcellular localization of an active cellulose biosynthesis apparatus at the bacterial cell pole.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • bacterial cellulose biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12261-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cellulose biosynthesis protein BcsQ
Gene namesi
Name:bcsQ
Synonyms:yhjQ
Ordered Locus Names:b3534
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12261. bcsQ.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Localizes at the cell pole.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Deletion abolishes cellulose production.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi14 – 141G → S: Loss of activity. 1 Publication
Mutagenesisi15 – 151T → Q: Does not affect activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Putative cellulose biosynthesis protein BcsQPRO_0000169575Add
BLAST

Proteomic databases

PRIDEiP37655.

Interactioni

Protein-protein interaction databases

DIPiDIP-12388N.
IntActiP37655. 2 interactions.
MINTiMINT-1223715.

Structurei

3D structure databases

ProteinModelPortaliP37655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal putative ATP-binding domain is required for function. The C-terminal region contributes to both localization and function in cellulose synthesis.1 Publication

Sequence similaritiesi

Belongs to the BcsQ family.Curated

Phylogenomic databases

HOGENOMiHOG000125946.
InParanoidiP37655.
OMAiVVHRDEA.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR017746. Cellulose_synthase_operon_BcsQ.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06564. CBP_BcsQ. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03371. cellulose_yhjQ. 1 hit.

Sequencei

Sequence statusi: Complete.

P37655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLGLQGVR GGVGTTTITA ALAWSLQMLG ENVLVVDACP DNLLRLSFNV
60 70 80 90 100
DFTHRQGWAR AMLDGQDWRD AGLRYTSQLD LLPFGQLSIE EQENPQHWQT
110 120 130 140 150
RLSDICSGLQ QLKASGRYQW ILIDLPRDAS QITHQLLSLC DHSLAIVNVD
160 170 180 190 200
ANCHIRLHQQ ALPDGAHILI NDFRIGSQVQ DDIYQLWLQS QRRLLPMLIH
210 220 230 240 250
RDEAMAECLA AKQPVGEYRS DALAAEEILT LANWCLLNYS GLKTPVGSAS
Length:250
Mass (Da):27,878
Last modified:October 25, 2004 - v3
Checksum:iE0A13C105B2D7AF7
GO

Sequence cautioni

The sequence AAB18512 differs from that shown. Reason: Erroneous termination at position 6. Translated as Leu.Curated
The sequence U00096 differs from that shown. Reason: Erroneous termination at position 6. Translated as Leu.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18512.1. Sequence problems.
U00096 Genomic DNA. No translation available.
PIRiS47756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18512.1. Sequence problems.
U00096 Genomic DNA. No translation available.
PIRiS47756.

3D structure databases

ProteinModelPortaliP37655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-12388N.
IntActiP37655. 2 interactions.
MINTiMINT-1223715.

Proteomic databases

PRIDEiP37655.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

EchoBASEiEB2170.
EcoGeneiEG12261. bcsQ.

Phylogenomic databases

HOGENOMiHOG000125946.
InParanoidiP37655.
OMAiVVHRDEA.

Enzyme and pathway databases

BioCyciEcoCyc:EG12261-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR017746. Cellulose_synthase_operon_BcsQ.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06564. CBP_BcsQ. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03371. cellulose_yhjQ. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBCSQ_ECOLI
AccessioniPrimary (citable) accession number: P37655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 25, 2004
Last modified: November 11, 2015
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Cellulose production is abolished in E.coli K12.

Caution

Could be the product of a pseudogene. The function of BcsQ was determined in a cellulose-producing E.coli strain 1094, which has an intact copy of the gene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.