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Protein

Cellulose synthase operon protein C

Gene

bcsC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for maximal bacterial cellulose synthesis.By similarity

Miscellaneous

The genes bscA, bcsB, bcsZ and bcsC are constitutively transcribed but cellulose synthesis occurs only when AdrA, a putative transmembrane protein regulated by AgfD, is expressed. Cellulose production is abolished in E.coli K12.

Pathwayi: bacterial cellulose biosynthesis

This protein is involved in the pathway bacterial cellulose biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway bacterial cellulose biosynthesis and in Glycan metabolism.

GO - Biological processi

Keywordsi

Biological processCellulose biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:EG12257-MONOMER.
UniPathwayiUPA00694.

Protein family/group databases

TCDBi1.B.55.3.1. the poly acetyl glucosamine porin (pgaa) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cellulose synthase operon protein C
Gene namesi
Name:bcsC
Synonyms:yhjL
Ordered Locus Names:b3530, JW5942
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12257. bcsC.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000010642924 – 1157Cellulose synthase operon protein CAdd BLAST1134

Proteomic databases

EPDiP37650.
PaxDbiP37650.
PRIDEiP37650.

Interactioni

Protein-protein interaction databases

BioGridi4261634. 107 interactors.
STRINGi511145.b3530.

Structurei

3D structure databases

ProteinModelPortaliP37650.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati62 – 95TPR 1Add BLAST34
Repeati112 – 145TPR 2Add BLAST34
Repeati269 – 302TPR 3Add BLAST34
Repeati303 – 336TPR 4Add BLAST34
Repeati351 – 384TPR 5Add BLAST34
Repeati385 – 418TPR 6Add BLAST34
Repeati461 – 494TPR 7Add BLAST34
Repeati603 – 636TPR 8Add BLAST34
Repeati710 – 744TPR 9Add BLAST35

Sequence similaritiesi

Belongs to the AcsC/BcsC family.Curated

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiENOG4105EJG. Bacteria.
COG0457. LUCA.
HOGENOMiHOG000125935.
InParanoidiP37650.
KOiK20543.

Family and domain databases

Gene3Di1.25.40.10. 5 hits.
InterProiView protein in InterPro
IPR008410. BCSC_C.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
PfamiView protein in Pfam
PF05420. BCSC_C. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 6 hits.
SUPFAMiSSF48452. SSF48452. 6 hits.
PROSITEiView protein in PROSITE
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKFTLNIFT LSLGLAVMPM VEAAPTAQQQ LLEQVRLGEA THREDLVQQS
60 70 80 90 100
LYRLELIDPN NPDVVAARFR SLLRQGDIDG AQKQLDRLSQ LAPSSNAYKS
110 120 130 140 150
SRTTMLLSTP DGRQALQQAR LQATTGHAEE AVASYNKLFN GAPPEGDIAV
160 170 180 190 200
EYWSTVAKIP ARRGEAINQL KRINADAPGN TGLQNNLALL LFSSDRRDEG
210 220 230 240 250
FAVLEQMAKS NAGREGASKI WYGQIKDMPV SDASVSALKK YLSIFSDGDS
260 270 280 290 300
VAAAQSQLAE QQKQLADPAF RARAQGLAAV DSGMAGKAIP ELQQAVRANP
310 320 330 340 350
KDSEALGALG QAYSQKGDRA NAVANLEKAL ALDPHSSNND KWNSLLKVNR
360 370 380 390 400
YWLAIQQGDA ALKANNPDRA ERLFQQARNV DNTDSYAVLG LGDVAMARKD
410 420 430 440 450
YPAAERYYQQ TLRMDSGNTN AVRGLANIYR QQSPEKAEAF IASLSASQRR
460 470 480 490 500
SIDDIERSLQ NDRLAQQAEA LENQGKWAQA AALQRQRLAL DPGSVWITYR
510 520 530 540 550
LSQDLWQAGQ RSQADTLMRN LAQQKSNDPE QVYAYGLYLS GHDQDRAALA
560 570 580 590 600
HINSLPRAQW NSNIQELVNR LQSDQVLETA NRLRESGKEA EAEAMLRQQP
610 620 630 640 650
PSTRIDLTLA DWAQQRRDYT AARAAYQNVL TREPANADAI LGLTEVDIAA
660 670 680 690 700
GDKAAARSQL AKLPATDNAS LNTQRRVALA QAQLGDTAAA QRTFNKLIPQ
710 720 730 740 750
AKSQPPSMES AMVLRDGAKF EAQAGDPTQA LETYKDAMVA SGVTTTRPQD
760 770 780 790 800
NDTFTRLTRN DEKDDWLKRG VRSDAADLYR QQDLNVTLEH DYWGSSGTGG
810 820 830 840 850
YSDLKAHTTM LQVDAPYSDG RMFFRSDFVN MNVGSFSTNA DGKWDDNWGT
860 870 880 890 900
CTLQDCSGNR SQSDSGASVA VGWRNDVWSW DIGTTPMGFN VVDVVGGISY
910 920 930 940 950
SDDIGPLGYT VNAHRRPISS SLLAFGGQKD SPSNTGKKWG GVRADGVGLS
960 970 980 990 1000
LSYDKGEANG VWASLSGDQL TGKNVEDNWR VRWMTGYYYK VINQNNRRVT
1010 1020 1030 1040 1050
IGLNNMIWHY DKDLSGYSLG QGGYYSPQEY LSFAIPVMWR ERTENWSWEL
1060 1070 1080 1090 1100
GASGSWSHSR TKTMPRYPLM NLIPTDWQEE AARQSNDGGS SQGFGYTARA
1110 1120 1130 1140 1150
LLERRVTSNW FVGTAIDIQQ AKDYAPSHFL LYVRYSAAGW QGDMDLPPQP

LIPYADW
Length:1,157
Mass (Da):127,724
Last modified:November 24, 2009 - v3
Checksum:iE99ADBAF20C0DC20
GO

Sequence cautioni

The sequence AAB18507 differs from that shown. Reason: Frameshift at position 11.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti594 – 595AM → V in AAB18507 (PubMed:8041620).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18507.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48188.4.
AP009048 Genomic DNA. Translation: BAE77764.1.
RefSeqiWP_001225124.1. NZ_LN832404.1.
YP_026226.4. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48188; AAT48188; b3530.
BAE77764; BAE77764; BAE77764.
GeneIDi948047.
KEGGiecj:JW5942.
eco:b3530.
PATRICi32122526. VBIEscCol129921_3641.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18507.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48188.4.
AP009048 Genomic DNA. Translation: BAE77764.1.
RefSeqiWP_001225124.1. NZ_LN832404.1.
YP_026226.4. NC_000913.3.

3D structure databases

ProteinModelPortaliP37650.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261634. 107 interactors.
STRINGi511145.b3530.

Protein family/group databases

TCDBi1.B.55.3.1. the poly acetyl glucosamine porin (pgaa) family.

Proteomic databases

EPDiP37650.
PaxDbiP37650.
PRIDEiP37650.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48188; AAT48188; b3530.
BAE77764; BAE77764; BAE77764.
GeneIDi948047.
KEGGiecj:JW5942.
eco:b3530.
PATRICi32122526. VBIEscCol129921_3641.

Organism-specific databases

EchoBASEiEB2166.
EcoGeneiEG12257. bcsC.

Phylogenomic databases

eggNOGiENOG4105EJG. Bacteria.
COG0457. LUCA.
HOGENOMiHOG000125935.
InParanoidiP37650.
KOiK20543.

Enzyme and pathway databases

UniPathwayiUPA00694.
BioCyciEcoCyc:EG12257-MONOMER.

Miscellaneous databases

PROiPR:P37650.

Family and domain databases

Gene3Di1.25.40.10. 5 hits.
InterProiView protein in InterPro
IPR008410. BCSC_C.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
PfamiView protein in Pfam
PF05420. BCSC_C. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 6 hits.
SUPFAMiSSF48452. SSF48452. 6 hits.
PROSITEiView protein in PROSITE
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiBCSC_ECOLI
AccessioniPrimary (citable) accession number: P37650
Secondary accession number(s): P76710, Q2M7J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 24, 2009
Last modified: April 12, 2017
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.