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Protein

Protein YhjK

Gene

yhjK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cyclic-nucleotide phosphodiesterase activity Source: EcoCyc
  • signal transducer activity Source: InterPro

GO - Biological processi

  • 3',5'-cyclic diguanylic acid metabolic process Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG12256-MONOMER.
ECOL316407:JW5943-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YhjK
Gene namesi
Name:yhjK
Ordered Locus Names:b3529, JW5943
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12256. yhjK.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001695741 – 662Protein YhjKAdd BLAST662

Proteomic databases

PaxDbiP37649.
PRIDEiP37649.

Expressioni

Inductioni

Expressed at 28 degrees Celsius in stationary phase.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262160. 6 interactors.
DIPiDIP-12384N.
IntActiP37649. 1 interactor.
STRINGi511145.b3529.

Structurei

3D structure databases

ProteinModelPortaliP37649.
SMRiP37649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini180 – 236HAMPPROSITE-ProRule annotationAdd BLAST57
Domaini268 – 400GGDEFPROSITE-ProRule annotationAdd BLAST133
Domaini409 – 662EALPROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Contains 1 EAL domain.PROSITE-ProRule annotation
Contains 1 GGDEF domain.PROSITE-ProRule annotation
Contains 1 HAMP domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000125924.
PhylomeDBiP37649.

Family and domain databases

CDDicd01948. EAL. 1 hit.
Gene3Di3.20.20.450. 1 hit.
InterProiIPR001633. EAL_dom.
IPR033419. GAPES3.
IPR000160. GGDEF_dom.
IPR003660. HAMP_dom.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00563. EAL. 1 hit.
PF17154. GAPES3. 1 hit.
PF00990. GGDEF. 1 hit.
PF00672. HAMP. 1 hit.
[Graphical view]
SMARTiSM00052. EAL. 1 hit.
SM00267. GGDEF. 1 hit.
[Graphical view]
SUPFAMiSSF141868. SSF141868. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS50883. EAL. 1 hit.
PS50887. GGDEF. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVSRSLTIK QMAMVAAVVL VFVFIFCTVL LFHLVQQNRY NTATQLESIA
60 70 80 90 100
RSVREPLSSA ILKGDIPEAE AILASIKPAG VVSRADVVLP NQFQALRKSF
110 120 130 140 150
IPERPVPVMV TRLFELPVQI SLGVYSLERP ANPQPIAYLV LQADSFRMYK
160 170 180 190 200
FVMSTLSTLV TIYLLLSLIL TVAISWCINR LILHPLRNIA RELNAIPAKE
210 220 230 240 250
LVGHQLALPR LHQDDEIGML VRSYNLNQQL LQRHYEEQNE NAMRFPVSDL
260 270 280 290 300
PNKALLMEML EQVVARKQTT ALMIITCETL RDTAGVLKEA QREILLLTLV
310 320 330 340 350
EKLKSVLSPR MILAQISGYD FAVIANGVQE PWHAITLGQQ VLTIMSERLP
360 370 380 390 400
IERIQLRPHC SIGVAMFYGD LTAEQLYSRA ISAAFTARHK GKNQIQFFDP
410 420 430 440 450
QQMEAAQKRL TEESDILNAL ENHQFAIWLQ PQVEMTSGKL VSAEVLLRIQ
460 470 480 490 500
QPDGSWDLPD GLIDRIECCG LMVTVGHWVL EESCRLLAAW QERGIMLPLS
510 520 530 540 550
VNLSALQLMH PNMVADMLEL LTRYRIQPGT LILEVTESRR IDDPHAAVAI
560 570 580 590 600
LRPLRNAGVR VALDDFGMGY AGLRQLQHMK SLPIDVLKID KMFVEGLPGD
610 620 630 640 650
SSMIAAIIML AQSLNLQMIA EGVETEAQRD WLAKAGVGIA QGFLFARPLP
660
IEIFEESYLE EK
Length:662
Mass (Da):74,381
Last modified:June 15, 2010 - v3
Checksum:i62CFA842B5851302
GO

Sequence cautioni

The sequence AAB18506 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE77765 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18506.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76554.4.
AP009048 Genomic DNA. Translation: BAE77765.1. Different initiation.
PIRiS47750.
RefSeqiNP_417986.4. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC76554; AAC76554; b3529.
BAE77765; BAE77765; BAE77765.
GeneIDi948048.
KEGGiecj:JW5943.
eco:b3529.
PATRICi32122524. VBIEscCol129921_3640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18506.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76554.4.
AP009048 Genomic DNA. Translation: BAE77765.1. Different initiation.
PIRiS47750.
RefSeqiNP_417986.4. NC_000913.3.

3D structure databases

ProteinModelPortaliP37649.
SMRiP37649.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262160. 6 interactors.
DIPiDIP-12384N.
IntActiP37649. 1 interactor.
STRINGi511145.b3529.

Proteomic databases

PaxDbiP37649.
PRIDEiP37649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76554; AAC76554; b3529.
BAE77765; BAE77765; BAE77765.
GeneIDi948048.
KEGGiecj:JW5943.
eco:b3529.
PATRICi32122524. VBIEscCol129921_3640.

Organism-specific databases

EchoBASEiEB2165.
EcoGeneiEG12256. yhjK.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000125924.
PhylomeDBiP37649.

Enzyme and pathway databases

BioCyciEcoCyc:EG12256-MONOMER.
ECOL316407:JW5943-MONOMER.

Miscellaneous databases

PROiP37649.

Family and domain databases

CDDicd01948. EAL. 1 hit.
Gene3Di3.20.20.450. 1 hit.
InterProiIPR001633. EAL_dom.
IPR033419. GAPES3.
IPR000160. GGDEF_dom.
IPR003660. HAMP_dom.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00563. EAL. 1 hit.
PF17154. GAPES3. 1 hit.
PF00990. GGDEF. 1 hit.
PF00672. HAMP. 1 hit.
[Graphical view]
SMARTiSM00052. EAL. 1 hit.
SM00267. GGDEF. 1 hit.
[Graphical view]
SUPFAMiSSF141868. SSF141868. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS50883. EAL. 1 hit.
PS50887. GGDEF. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYHJK_ECOLI
AccessioniPrimary (citable) accession number: P37649
Secondary accession number(s): Q2M7J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: June 15, 2010
Last modified: November 2, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.