Reviewed, UniProtKB/Swiss-Prot P37647 (KDGK_ECOLI)

Names and origin

Protein names

Recommended name:
    2-dehydro-3-deoxygluconokinase
    EC=2.7.1.45
Alternative name(s):
    2-keto-3-deoxygluconokinase
    3-deoxy-2-oxo-D-gluconate kinase
    KDG kinase

Gene names

Name:	kdgK
Synonyms:	yhjI
Ordered Locus Names:	b3526, JW5668

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate.
Sequence similarities	Belongs to the carbohydrate kinase pfkB family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	2-dehydro-3-deoxygluconokinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	2-dehydro-3-deoxygluconokinase		PRO_0000080085

Sequences

	Sequence		Length	Mass (Da)
	P37647-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 53FCD14696BCFA33	FASTA	309	33,962
	10 20 30 40 50 60 MSKKIAVIGE CMIELSEKGA DVKRGFGGDT LNTSVYIARQ VDPAALTVHY VTALGTDSFS 70 80 90 100 110 120 QQMLDAWHGE NVDTSLTQRM ENRLPGLYYI ETDSTGERTF YYWRNEAAAK FWLESEQSAA 130 140 150 160 170 180 ICEELANFDY LYLSGISLAI LSPTSREKLL SLLRECRANG GKVIFDNNYR PRLWASKEET 190 200 210 220 230 240 QQVYQQMLEC TDIAFLTLDD EDALWGQQPV EDVIARTHNA GVKEVVVKRG ADSCLVSIAG 250 260 270 280 290 300 EGLVDVPAVK LPKEKVIDTT AAGDSFSAGY LAVRLTGGSA EDAAKRGHLT ASTVIQYRGA IIPREAMPA

References

[1]	"Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes." Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R. Nucleic Acids Res. 22:2576-2586(1994) [PubMed: 8041620] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00039 Genomic DNA. Translation: AAB18503.1. Different initiation. U00096 Genomic DNA. Translation: AAC76551.1. Different initiation. AP009048 Genomic DNA. Translation: BAE77768.1.
PIR	S47747.
RefSeq	AP_004267.1. NP_417983.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:10056N.
STRING	P37647.
Genome annotation databases
GeneID	948041.
GenomeReviews	Gene locus JW5668 in contig AP009048_GR. Gene locus b3526 in contig U00096_GR.
KEGG	ecj:JW5668. eco:b3526.
Organism-specific databases
EchoBASE	EB2163.
EcoGene	EG12253. kdgK.
CMR	Search...
Phylogenomic databases
HOGENOM	P37647.
OMA	ANFLQIR.
Enzyme and pathway databases
BioCyc	EcoCyc:DEOXYGLUCONOKIN-MON. MetaCyc:DEOXYGLUCONOKIN-MON.
Gene expression databases
Genevestigator	P37647.
Family and domain databases
InterPro	IPR011611. Carb/pur_kinase. IPR002173. Carboh/pur_kinase_PfkB_CS. [Graphical view]
Pfam	PF00294. PfkB. 1 hit. [Graphical view]
PROSITE	PS00583. PFKB_KINASES_1. False negative. PS00584. PFKB_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KDGK_ECOLI

Accession

Primary (citable) accession number: P37647
Secondary accession number(s): P78117, Q2M7I8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	November 3, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)