P37641 (YHJC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized HTH-type transcriptional regulator yhjC

Gene names

Name:	yhjC
Ordered Locus Names:	b3521, JW3489

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Sequence similarities	Contains 1 HTH lysR-type DNA-binding domain.
Sequence caution	The sequence AAB18497.1 differs from that shown. Reason: Erroneous initiation. The sequence BAE77773.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Uncharacterized HTH-type transcriptional regulator yhjC		PRO_0000105799
Regions
	Domain	1 – 59	59	HTH lysR-type
	DNA binding	19 – 38	20	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	P37641 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: 22D0EC5994CBC8C1	FASTA	299	33,330
	10 20 30 40 50 60 MDKIHAMQLF IKVAELESFS RAADFFALPK GSVSRQIQAL EHQLGTQLLQ RTTRRVKLTP 70 80 90 100 110 120 EGMTYYQRAK DVLSNLSELD GLFQQDATSI SGKLRIDIPP GIAKSLLLPR LSEFLYLHPG 130 140 150 160 170 180 IELELSSHDR PVDILHDGFD CVIRTGALPE DGVIARPLGK LTMVNCASPH YLTRFGYPQS 190 200 210 220 230 240 PDDLTSHAIV RYTPHLGVHP LGFEVASVNG VQWFKSGGML TVNSSENYLT AGLAGLGIIQ 250 260 270 280 290 IPRIAVREAL RAGRLIEVLP GYRAEPLSLS LVYPQRRELS RRVNLFMQWL AGVMKEYLD

References

[1]	"Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes." Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R. Nucleic Acids Res. 22:2576-2586(1994) [PubMed: 8041620] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00039 Genomic DNA. Translation: AAB18497.1. Different initiation. U00096 Genomic DNA. Translation: AAC76546.2. AP009048 Genomic DNA. Translation: BAE77773.1. Different initiation.
PIR	S47741.
RefSeq	NP_417978.2. NC_000913.2.
3D structure databases
ProteinModelPortal	P37641.
SMR	P37641. Positions 1-298.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-12378N.
IntAct	P37641. 2 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000001705; EBESCP00000001705; EBESCG00000001404. EBESCT00000015924; EBESCP00000015215; EBESCG00000014984.
GeneID	948035.
GenomeReviews	Gene locus JW3489 in contig AP009048_GR. Gene locus b3521 in contig U00096_GR.
KEGG	ecj:JW3489. eco:b3521.
PATRIC	32122504. VBIEscCol129921_3630.
Organism-specific databases
EchoBASE	EB2158.
EcoGene	EG12247. yhjC.
Phylogenomic databases
eggNOG	COG0583.
GeneTree	EBGT00050000008331.
HOGENOM	HBG685425.
OMA	AMQLFIR.
PhylomeDB	P37641.
ProtClustDB	CLSK880702.
Enzyme and pathway databases
BioCyc	EcoCyc:EG12247-MONOMER.
Gene expression databases
Genevestigator	P37641.
Family and domain databases
InterPro	IPR005119. LysR_subst-bd. IPR000847. Tscrpt_reg_HTH_LysR. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF00126. HTH_1. 1 hit. PF03466. LysR_substrate. 1 hit. [Graphical view]
PROSITE	PS50931. HTH_LYSR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YHJC_ECOLI

Accession

Primary (citable) accession number: P37641
Secondary accession number(s): Q2M7I3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	December 15, 1998
Last modified:	January 25, 2012
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program