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Protein

Multidrug resistance protein MdtE

Gene

mdtE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntibiotic resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG12240-MONOMER

Protein family/group databases

TCDBi8.A.1.6.3 the membrane fusion protein (mfp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtE
Gene namesi
Name:mdtE
Synonyms:yhiU
Ordered Locus Names:b3513, JW3481
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12240 mdtE

Subcellular locationi

  • Cell inner membrane Curated; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

  • intrinsic component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20PROSITE-ProRule annotationAdd BLAST20
ChainiPRO_000001870821 – 385Multidrug resistance protein MdtEAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi21N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi21S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP37636
PRIDEiP37636

Expressioni

Inductioni

Induced by EvgA, probably via YdeO.4 Publications

Interactioni

Subunit structurei

Homotrimer. Part of the tripartite efflux system MdtEF-TolC, which is composed of an inner membrane transporter, MdtF, a membrane fusion protein, MdtE, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes.2 Publications

Protein-protein interaction databases

BioGridi4262520, 226 interactors
IntActiP37636, 4 interactors
STRINGi316385.ECDH10B_3689

Structurei

3D structure databases

ProteinModelPortaliP37636
SMRiP37636
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1P Bacteria
ENOG410XNVN LUCA
HOGENOMiHOG000158247
InParanoidiP37636
KOiK18898
OMAiNIAFRAT
PhylomeDBiP37636

Family and domain databases

InterProiView protein in InterPro
IPR032317 HlyD_D23
IPR006143 RND_pump_MFP
PfamiView protein in Pfam
PF00529 HlyD, 1 hit
PF16576 HlyD_D23, 1 hit
TIGRFAMsiTIGR01730 RND_mfp, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRRRKLLIP LLFCGAMLTA CDDKSAENAA AMTPEVGVVT LSPGSVNVLS
60 70 80 90 100
ELPGRTVPYE VAEIRPQVGG IIIKRNFIEG DKVNQGDSLY QIDPAPLQAE
110 120 130 140 150
LNSAKGSLAK ALSTASNARI TFNRQASLLK TNYVSRQDYD TARTQLNEAE
160 170 180 190 200
ANVTVAKAAV EQATINLQYA NVTSPITGVS GKSSVTVGAL VTANQADSLV
210 220 230 240 250
TVQRLDPIYV DLTQSVQDFL RMKEEVASGQ IKQVQGSTPV QLNLENGKRY
260 270 280 290 300
SQTGTLKFSD PTVDETTGSV TLRAIFPNPN GDLLPGMYVT ALVDEGSRQN
310 320 330 340 350
VLLVPQEGVT HNAQGKATAL ILDKDDVVQL REIEASKAIG DQWVVTSGLQ
360 370 380
AGDRVIVSGL QRIRPGIKAR AISSSQENAS TESKQ
Length:385
Mass (Da):41,191
Last modified:October 1, 1994 - v1
Checksum:i2C825B6CDE15C70F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18489.1
U00096 Genomic DNA Translation: AAC76538.1
AP009048 Genomic DNA Translation: BAE77781.1
PIRiS47733
RefSeqiNP_417970.1, NC_000913.3
WP_001081984.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76538; AAC76538; b3513
BAE77781; BAE77781; BAE77781
GeneIDi948031
KEGGiecj:JW3481
eco:b3513
PATRICifig|1411691.4.peg.3205

Similar proteinsi

Entry informationi

Entry nameiMDTE_ECOLI
AccessioniPrimary (citable) accession number: P37636
Secondary accession number(s): Q2M7H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health