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Protein

4'-phosphopantetheinyl transferase AcpT

Gene

acpT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis in E.coli. The native apo-protein substrate is unknown. Is able to functionally replace AcpS in vivo but only when expressed at high levels.2 Publications

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].1 Publication

GO - Molecular functioni

  • holo-[acyl-carrier-protein] synthase activity Source: EcoCyc
  • magnesium ion binding Source: InterPro

GO - Biological processi

  • fatty acid biosynthetic process Source: EcoliWiki
  • lysine biosynthetic process via aminoadipic acid Source: GO_Central
  • peptidyl-serine phosphopantetheinylation Source: EcoliWiki

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciEcoCyc:EG12221-MONOMER
MetaCyc:EG12221-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
4'-phosphopantetheinyl transferase AcpT (EC:2.7.8.71 Publication)
Gene namesi
Name:acpT1 Publication
Synonyms:yhhU
Ordered Locus Names:b3475, JW3440
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12221 acpT

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002060811 – 1954'-phosphopantetheinyl transferase AcpTAdd BLAST195

Proteomic databases

PaxDbiP37623
PRIDEiP37623

Interactioni

Protein-protein interaction databases

BioGridi4259300, 100 interactors
DIPiDIP-12355N
IntActiP37623, 1 interactor
STRINGi316385.ECDH10B_3649

Structurei

3D structure databases

ProteinModelPortaliP37623
SMRiP37623
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107YAK Bacteria
COG2091 LUCA
HOGENOMiHOG000125719
InParanoidiP37623
KOiK06133
OMAiWQIVSID
PhylomeDBiP37623

Family and domain databases

Gene3Di3.90.470.20, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
SUPFAMiSSF56214 SSF56214, 2 hits

Sequencei

Sequence statusi: Complete.

P37623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRIVLGKVS TLSAAPLPPG LREQAPQGPR RERWLAGRAL LSHTLSPLPE
60 70 80 90 100
IIYGEQGKPA FAPEMPLWFN LSHSGDDIAL LLSDEGEVGC DIEVIRPRAN
110 120 130 140 150
WRWLANAVFS LGEHAEMDAV HPDQQLEMFW RIWTRKEAIV KQRGGSAWQI
160 170 180 190
VSVDSTYHSS LSVSHCQLEN LSLAICTPTP FTLTADSVQW IDSVN
Length:195
Mass (Da):21,768
Last modified:October 1, 1994 - v1
Checksum:i29385FDA343B2AB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18450.1
U00096 Genomic DNA Translation: AAC76500.1
AP009048 Genomic DNA Translation: BAE77818.1
PIRiS47694
RefSeqiNP_417932.1, NC_000913.3
WP_000285774.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76500; AAC76500; b3475
BAE77818; BAE77818; BAE77818
GeneIDi947979
KEGGiecj:JW3440
eco:b3475
PATRICifig|1411691.4.peg.3250

Similar proteinsi

Entry informationi

Entry nameiACPT_ECOLI
AccessioniPrimary (citable) accession number: P37623
Secondary accession number(s): Q2M7D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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