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Protein

4'-phosphopantetheinyl transferase AcpT

Gene

acpT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis in E.coli. The native apo-protein substrate is unknown. Is able to functionally replace AcpS in vivo but only when expressed at high levels.2 Publications

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].1 Publication

GO - Molecular functioni

  • holo-[acyl-carrier-protein] synthase activity Source: EcoliWiki
  • magnesium ion binding Source: InterPro

GO - Biological processi

  • fatty acid biosynthetic process Source: EcoliWiki
  • lysine biosynthetic process via aminoadipic acid Source: GO_Central
  • peptidyl-serine phosphopantetheinylation Source: EcoliWiki
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciEcoCyc:EG12221-MONOMER.
ECOL316407:JW3440-MONOMER.
MetaCyc:EG12221-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
4'-phosphopantetheinyl transferase AcpT (EC:2.7.8.71 Publication)
Gene namesi
Name:acpT1 Publication
Synonyms:yhhU
Ordered Locus Names:b3475, JW3440
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12221. acpT.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002060811 – 1954'-phosphopantetheinyl transferase AcpTAdd BLAST195

Proteomic databases

PaxDbiP37623.
PRIDEiP37623.

Interactioni

Protein-protein interaction databases

BioGridi4259300. 97 interactors.
DIPiDIP-12355N.
IntActiP37623. 1 interactor.
STRINGi511145.b3475.

Structurei

3D structure databases

ProteinModelPortaliP37623.
SMRiP37623.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107YAK. Bacteria.
COG2091. LUCA.
HOGENOMiHOG000125719.
InParanoidiP37623.
KOiK06133.
OMAiWQIVSID.
PhylomeDBiP37623.

Family and domain databases

Gene3Di3.90.470.20. 2 hits.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
SUPFAMiSSF56214. SSF56214. 2 hits.

Sequencei

Sequence statusi: Complete.

P37623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRIVLGKVS TLSAAPLPPG LREQAPQGPR RERWLAGRAL LSHTLSPLPE
60 70 80 90 100
IIYGEQGKPA FAPEMPLWFN LSHSGDDIAL LLSDEGEVGC DIEVIRPRAN
110 120 130 140 150
WRWLANAVFS LGEHAEMDAV HPDQQLEMFW RIWTRKEAIV KQRGGSAWQI
160 170 180 190
VSVDSTYHSS LSVSHCQLEN LSLAICTPTP FTLTADSVQW IDSVN
Length:195
Mass (Da):21,768
Last modified:October 1, 1994 - v1
Checksum:i29385FDA343B2AB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18450.1.
U00096 Genomic DNA. Translation: AAC76500.1.
AP009048 Genomic DNA. Translation: BAE77818.1.
PIRiS47694.
RefSeqiNP_417932.1. NC_000913.3.
WP_000285774.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76500; AAC76500; b3475.
BAE77818; BAE77818; BAE77818.
GeneIDi947979.
KEGGiecj:JW3440.
eco:b3475.
PATRICi32122394. VBIEscCol129921_3574.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18450.1.
U00096 Genomic DNA. Translation: AAC76500.1.
AP009048 Genomic DNA. Translation: BAE77818.1.
PIRiS47694.
RefSeqiNP_417932.1. NC_000913.3.
WP_000285774.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37623.
SMRiP37623.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259300. 97 interactors.
DIPiDIP-12355N.
IntActiP37623. 1 interactor.
STRINGi511145.b3475.

Proteomic databases

PaxDbiP37623.
PRIDEiP37623.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76500; AAC76500; b3475.
BAE77818; BAE77818; BAE77818.
GeneIDi947979.
KEGGiecj:JW3440.
eco:b3475.
PATRICi32122394. VBIEscCol129921_3574.

Organism-specific databases

EchoBASEiEB2135.
EcoGeneiEG12221. acpT.

Phylogenomic databases

eggNOGiENOG4107YAK. Bacteria.
COG2091. LUCA.
HOGENOMiHOG000125719.
InParanoidiP37623.
KOiK06133.
OMAiWQIVSID.
PhylomeDBiP37623.

Enzyme and pathway databases

BioCyciEcoCyc:EG12221-MONOMER.
ECOL316407:JW3440-MONOMER.
MetaCyc:EG12221-MONOMER.

Miscellaneous databases

PROiP37623.

Family and domain databases

Gene3Di3.90.470.20. 2 hits.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
SUPFAMiSSF56214. SSF56214. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiACPT_ECOLI
AccessioniPrimary (citable) accession number: P37623
Secondary accession number(s): Q2M7D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.