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Protein

UPF0226 protein YhhS

Gene

yhhS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:YHHS-MONOMER.
ECOL316407:JW5945-MONOMER.

Protein family/group databases

TCDBi2.A.1.46.7. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0226 protein YhhS
Gene namesi
Name:yhhS
Ordered Locus Names:b3473, JW5945
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12219. yhhS.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence analysisAdd
BLAST
Transmembranei19 – 3921HelicalSequence analysisAdd
BLAST
Topological domaini40 – 467PeriplasmicSequence analysis
Transmembranei47 – 6721HelicalSequence analysisAdd
BLAST
Topological domaini68 – 8417CytoplasmicSequence analysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence analysisAdd
BLAST
Topological domaini106 – 1061PeriplasmicSequence analysis
Transmembranei107 – 12721HelicalSequence analysisAdd
BLAST
Topological domaini128 – 15528CytoplasmicSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Topological domaini177 – 1771PeriplasmicSequence analysis
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST
Topological domaini199 – 22325CytoplasmicSequence analysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence analysisAdd
BLAST
Topological domaini245 – 2517PeriplasmicSequence analysis
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST
Topological domaini273 – 28210CytoplasmicSequence analysis
Transmembranei283 – 30321HelicalSequence analysisAdd
BLAST
Topological domaini304 – 3085PeriplasmicSequence analysis
Transmembranei309 – 32921HelicalSequence analysisAdd
BLAST
Topological domaini330 – 34314CytoplasmicSequence analysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence analysisAdd
BLAST
Topological domaini365 – 3651PeriplasmicSequence analysis
Transmembranei366 – 38621HelicalSequence analysisAdd
BLAST
Topological domaini387 – 40519CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405UPF0226 protein YhhSPRO_0000087807Add
BLAST

Proteomic databases

PaxDbiP37621.

Interactioni

Protein-protein interaction databases

BioGridi4263334. 141 interactions.
STRINGi511145.b3473.

Structurei

3D structure databases

ProteinModelPortaliP37621.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0226 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105F9N. Bacteria.
ENOG410XNX3. LUCA.
HOGENOMiHOG000122488.
InParanoidiP37621.
OMAiCAFVGAR.
OrthoDBiEOG6S268F.
PhylomeDBiP37621.

Family and domain databases

HAMAPiMF_01118. UPF0226.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023008. UPF0226_MFS.
[Graphical view]
PfamiPF07690. MFS_1. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEPVAEPAL NGLRLNLRIV SIVMFNFASY LTIGLPLAVL PGYVHDVMGF
60 70 80 90 100
SAFWAGLVIS LQYFATLLSR PHAGRYADSL GPKKIVVFGL CGCFLSGLGY
110 120 130 140 150
LTAGLTASLP VISLLLLCLG RVILGIGQSF AGTGSTLWGV GVVGSLHIGR
160 170 180 190 200
VISWNGIVTY GAMAMGAPLG VVFYHWGGLQ ALALIIMGVA LVAILLAIPR
210 220 230 240 250
PTVKASKGKP LPFRAVLGRV WLYGMALALA SAGFGVIATF ITLFYDAKGW
260 270 280 290 300
DGAAFALTLF SCAFVGTRLL FPNGINRIGG LNVAMICFSV EIIGLLLVGV
310 320 330 340 350
ATMPWMAKIG VLLAGAGFSL VFPALGVVAV KAVPQQNQGA ALATYTVFMD
360 370 380 390 400
LSLGVTGPLA GLVMSWAGVP VIYLAAAGLV AIALLLTWRL KKRPPEHVPE

AASSS
Length:405
Mass (Da):42,156
Last modified:December 4, 2007 - v2
Checksum:i4FC17F42FFAE51D1
GO

Sequence cautioni

The sequence AAB18448.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18448.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76498.2.
AP009048 Genomic DNA. Translation: BAE77820.1.
PIRiS47692.
RefSeqiNP_417930.2. NC_000913.3.
WP_001300943.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76498; AAC76498; b3473.
BAE77820; BAE77820; BAE77820.
GeneIDi947982.
KEGGiecj:JW5945.
eco:b3473.
PATRICi32122390. VBIEscCol129921_3572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18448.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76498.2.
AP009048 Genomic DNA. Translation: BAE77820.1.
PIRiS47692.
RefSeqiNP_417930.2. NC_000913.3.
WP_001300943.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37621.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263334. 141 interactions.
STRINGi511145.b3473.

Protein family/group databases

TCDBi2.A.1.46.7. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP37621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76498; AAC76498; b3473.
BAE77820; BAE77820; BAE77820.
GeneIDi947982.
KEGGiecj:JW5945.
eco:b3473.
PATRICi32122390. VBIEscCol129921_3572.

Organism-specific databases

EchoBASEiEB2133.
EcoGeneiEG12219. yhhS.

Phylogenomic databases

eggNOGiENOG4105F9N. Bacteria.
ENOG410XNX3. LUCA.
HOGENOMiHOG000122488.
InParanoidiP37621.
OMAiCAFVGAR.
OrthoDBiEOG6S268F.
PhylomeDBiP37621.

Enzyme and pathway databases

BioCyciEcoCyc:YHHS-MONOMER.
ECOL316407:JW5945-MONOMER.

Miscellaneous databases

PROiP37621.

Family and domain databases

HAMAPiMF_01118. UPF0226.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023008. UPF0226_MFS.
[Graphical view]
PfamiPF07690. MFS_1. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."
    Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.
    Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYHHS_ECOLI
AccessioniPrimary (citable) accession number: P37621
Secondary accession number(s): Q2M7D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: December 4, 2007
Last modified: January 20, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.