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Protein

Queuosine precursor transporter

Gene

yhhQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. Transports 7-cyano-7-deazaguanine (preQ0) and 7-aminomethyl-7-deazaguanine (preQ1), with a preference for preQ0.1 Publication

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:EG12217-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Queuosine precursor transporterCurated
Short name:
Q precursor transporterUniRule annotationCurated
Gene namesi
Name:yhhQ
Ordered Locus Names:b3471, JW3436
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12217 yhhQ

Subcellular locationi

  • Cell inner membrane UniRule annotation1 Publication; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicCuratedAdd BLAST12
Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Topological domaini34PeriplasmicCurated1
Transmembranei35 – 55HelicalUniRule annotationAdd BLAST21
Topological domaini56 – 70CytoplasmicCuratedAdd BLAST15
Transmembranei71 – 91HelicalUniRule annotationAdd BLAST21
Topological domaini92 – 97PeriplasmicCurated6
Transmembranei98 – 118HelicalUniRule annotationAdd BLAST21
Topological domaini119 – 143CytoplasmicCuratedAdd BLAST25
Transmembranei144 – 164HelicalUniRule annotationAdd BLAST21
Topological domaini165 – 184PeriplasmicCuratedAdd BLAST20
Transmembranei185 – 205HelicalUniRule annotationAdd BLAST21
Topological domaini206 – 221Cytoplasmic1 PublicationAdd BLAST16

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

YhhQ-queD double mutant cannot produce Q modified tRNA in minimal media with preQ0 or preQ1. YhhQ expressed from a plasmid restores the presence of Q modified tRNA.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001695561 – 221Queuosine precursor transporterAdd BLAST221

Proteomic databases

PaxDbiP37619
PRIDEiP37619

Interactioni

Protein-protein interaction databases

STRINGi316385.ECDH10B_3645

Structurei

3D structure databases

ProteinModelPortaliP37619
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. [View classification]UniRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EX9 Bacteria
COG1738 LUCA
HOGENOMiHOG000284591
InParanoidiP37619
KOiK09125
OMAiIWLSLFH
PhylomeDBiP37619

Family and domain databases

HAMAPiMF_02088 Q_prec_transport, 1 hit
InterProiView protein in InterPro
IPR003744 YhhQ
PANTHERiPTHR34300 PTHR34300, 1 hit
PfamiView protein in Pfam
PF02592 Vut_1, 1 hit
TIGRFAMsiTIGR00697 TIGR00697, 1 hit

Sequencei

Sequence statusi: Complete.

P37619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVFSQTQRY KALFWLSLFH LLVITSSNYL VQLPVSILGF HTTWGAFSFP
60 70 80 90 100
FIFLATDLTV RIFGAPLARR IIFAVMIPAL LISYVISSLF YMGSWQGFGA
110 120 130 140 150
LAHFNLFVAR IATASFMAYA LGQILDVHVF NRLRQSRRWW LAPTASTLFG
160 170 180 190 200
NVSDTLAFFF IAFWRSPDAF MAEHWMEIAL VDYCFKVLIS IVFFLPMYGV
210 220
LLNMLLKRLA DKSEINALQA S
Length:221
Mass (Da):25,269
Last modified:October 1, 1994 - v1
Checksum:iE3D90237BEE7ABCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18446.1
U00096 Genomic DNA Translation: AAC76496.1
AP009048 Genomic DNA Translation: BAE77822.1
PIRiS47690
RefSeqiNP_417928.1, NC_000913.3
WP_001100469.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76496; AAC76496; b3471
BAE77822; BAE77822; BAE77822
GeneIDi947984
KEGGiecj:JW3436
eco:b3471
PATRICifig|1411691.4.peg.3254

Similar proteinsi

Entry informationi

Entry nameiQPTR_ECOLI
AccessioniPrimary (citable) accession number: P37619
Secondary accession number(s): Q2M7D4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health