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Protein

Queuosine precursor transporter

Gene

yhhQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. Transports 7-cyano-7-deazaguanine (preQ0) and 7-aminomethyl-7-deazaguanine (preQ1), with a preference for preQ0.1 Publication

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:EG12217-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Queuosine precursor transporterCurated
Short name:
Q precursor transporterUniRule annotationCurated
Gene namesi
Name:yhhQ
Ordered Locus Names:b3471, JW3436
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12217. yhhQ.

Subcellular locationi

  • Cell inner membrane UniRule annotation1 Publication; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicCuratedAdd BLAST12
Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Topological domaini34PeriplasmicCurated1
Transmembranei35 – 55HelicalUniRule annotationAdd BLAST21
Topological domaini56 – 70CytoplasmicCuratedAdd BLAST15
Transmembranei71 – 91HelicalUniRule annotationAdd BLAST21
Topological domaini92 – 97PeriplasmicCurated6
Transmembranei98 – 118HelicalUniRule annotationAdd BLAST21
Topological domaini119 – 143CytoplasmicCuratedAdd BLAST25
Transmembranei144 – 164HelicalUniRule annotationAdd BLAST21
Topological domaini165 – 184PeriplasmicCuratedAdd BLAST20
Transmembranei185 – 205HelicalUniRule annotationAdd BLAST21
Topological domaini206 – 221Cytoplasmic1 PublicationAdd BLAST16

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

YhhQ-queD double mutant cannot produce Q modified tRNA in minimal media with preQ0 or preQ1. YhhQ expressed from a plasmid restores the presence of Q modified tRNA.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001695561 – 221Queuosine precursor transporterAdd BLAST221

Proteomic databases

PaxDbiP37619.
PRIDEiP37619.

Interactioni

Protein-protein interaction databases

STRINGi316385.ECDH10B_3645.

Structurei

3D structure databases

ProteinModelPortaliP37619.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. [View classification]UniRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EX9. Bacteria.
COG1738. LUCA.
HOGENOMiHOG000284591.
InParanoidiP37619.
KOiK09125.
PhylomeDBiP37619.

Family and domain databases

HAMAPiMF_02088. Q_prec_transport. 1 hit.
InterProiView protein in InterPro
IPR003744. YhhQ.
PANTHERiPTHR34300. PTHR34300. 1 hit.
PfamiView protein in Pfam
PF02592. Vut_1. 1 hit.
TIGRFAMsiTIGR00697. TIGR00697. 1 hit.

Sequencei

Sequence statusi: Complete.

P37619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVFSQTQRY KALFWLSLFH LLVITSSNYL VQLPVSILGF HTTWGAFSFP
60 70 80 90 100
FIFLATDLTV RIFGAPLARR IIFAVMIPAL LISYVISSLF YMGSWQGFGA
110 120 130 140 150
LAHFNLFVAR IATASFMAYA LGQILDVHVF NRLRQSRRWW LAPTASTLFG
160 170 180 190 200
NVSDTLAFFF IAFWRSPDAF MAEHWMEIAL VDYCFKVLIS IVFFLPMYGV
210 220
LLNMLLKRLA DKSEINALQA S
Length:221
Mass (Da):25,269
Last modified:October 1, 1994 - v1
Checksum:iE3D90237BEE7ABCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18446.1.
U00096 Genomic DNA. Translation: AAC76496.1.
AP009048 Genomic DNA. Translation: BAE77822.1.
PIRiS47690.
RefSeqiNP_417928.1. NC_000913.3.
WP_001100469.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76496; AAC76496; b3471.
BAE77822; BAE77822; BAE77822.
GeneIDi947984.
KEGGiecj:JW3436.
eco:b3471.
PATRICifig|1411691.4.peg.3254.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQPTR_ECOLI
AccessioniPrimary (citable) accession number: P37619
Secondary accession number(s): Q2M7D4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 5, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families