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Protein

PanD maturation factor

Gene

panM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acetyl-coenzyme A (CoA) sensor, which is involved in the conversion of inactive pro-PanD into active PanD. Binding of acetyl-CoA stimulates PanM activity, accelerating PanD cleavage by an acetylation-independent mechanism.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

  • pantothenate biosynthetic process Source: EcoCyc
  • protein processing Source: EcoCyc
  • zymogen activation Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Pantothenate biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:EG12211-MONOMER.
ECOL316407:JW3424-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
PanD maturation factorUniRule annotationCurated
Gene namesi
Name:panMUniRule annotationBy similarityImported
Synonyms:panZ1 Publication, yhhK
Ordered Locus Names:b3459, JW3424
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12211. panM.

Pathology & Biotechi

Disruption phenotypei

Deletion mutants are deficient in the biosynthetic pathway for pantothenate.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi45 – 451N → A: Retains affinity for PanD, but is unable to enhance cleavage of the PanD proenzyme. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127PanD maturation factorPRO_0000169553Add
BLAST

Proteomic databases

EPDiP37613.
PaxDbiP37613.
PRIDEiP37613.

Interactioni

Subunit structurei

Interacts with PanD.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi4262496. 7 interactions.
IntActiP37613. 2 interactions.
STRINGi511145.b3459.

Structurei

Secondary structure

1
127
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 74Combined sources
Helixi13 – 2210Combined sources
Beta strandi28 – 303Combined sources
Beta strandi37 – 448Combined sources
Beta strandi47 – 5711Combined sources
Beta strandi60 – 689Combined sources
Helixi70 – 723Combined sources
Beta strandi73 – 764Combined sources
Helixi77 – 8711Combined sources
Beta strandi94 – 985Combined sources
Helixi105 – 11410Combined sources
Beta strandi118 – 1203Combined sources
Beta strandi123 – 1264Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K5TNMR-A1-127[»]
4CRYX-ray1.61B1-127[»]
4CRZX-ray1.70B1-127[»]
4CS0X-ray2.10B1-127[»]
ProteinModelPortaliP37613.
SMRiP37613. Positions 1-127.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37613.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 127127N-acetyltransferaseUniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 683Coenzyme A bindingUniRule annotation1 Publication
Regioni72 – 798Coenzyme A bindingUniRule annotation1 Publication

Sequence similaritiesi

Belongs to the PanM family.UniRule annotationCurated
Contains 1 N-acetyltransferase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105U59. Bacteria.
ENOG4111V7B. LUCA.
HOGENOMiHOG000125696.
InParanoidiP37613.
OMAiRGVMAAF.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
HAMAPiMF_02018. PanM. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR032900. PanM.
[Graphical view]
PfamiPF12568. DUF3749. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTIIRLEK FSDQDRIDLQ KIWPEYSPSS LQVDDNHRIY AARFNERLLA
60 70 80 90 100
AVRVTLSGTE GALDSLRVRE VTRRRGVGQY LLEEVLRNNP GVSCWWMADA
110 120
GVEDRGVMTA FMQALGFTAQ QGGWEKC
Length:127
Mass (Da):14,506
Last modified:October 1, 1994 - v1
Checksum:iEF054A30D294519A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18434.1.
U00096 Genomic DNA. Translation: AAC76484.1.
AP009048 Genomic DNA. Translation: BAE77834.1.
PIRiS47678.
RefSeqiNP_417916.1. NC_000913.3.
WP_000778768.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76484; AAC76484; b3459.
BAE77834; BAE77834; BAE77834.
GeneIDi947963.
KEGGiecj:JW3424.
eco:b3459.
PATRICi32122362. VBIEscCol129921_3558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18434.1.
U00096 Genomic DNA. Translation: AAC76484.1.
AP009048 Genomic DNA. Translation: BAE77834.1.
PIRiS47678.
RefSeqiNP_417916.1. NC_000913.3.
WP_000778768.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K5TNMR-A1-127[»]
4CRYX-ray1.61B1-127[»]
4CRZX-ray1.70B1-127[»]
4CS0X-ray2.10B1-127[»]
ProteinModelPortaliP37613.
SMRiP37613. Positions 1-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262496. 7 interactions.
IntActiP37613. 2 interactions.
STRINGi511145.b3459.

Proteomic databases

EPDiP37613.
PaxDbiP37613.
PRIDEiP37613.

Protocols and materials databases

DNASUi947963.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76484; AAC76484; b3459.
BAE77834; BAE77834; BAE77834.
GeneIDi947963.
KEGGiecj:JW3424.
eco:b3459.
PATRICi32122362. VBIEscCol129921_3558.

Organism-specific databases

EchoBASEiEB2125.
EcoGeneiEG12211. panM.

Phylogenomic databases

eggNOGiENOG4105U59. Bacteria.
ENOG4111V7B. LUCA.
HOGENOMiHOG000125696.
InParanoidiP37613.
OMAiRGVMAAF.

Enzyme and pathway databases

BioCyciEcoCyc:EG12211-MONOMER.
ECOL316407:JW3424-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP37613.
PROiP37613.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
HAMAPiMF_02018. PanM. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR032900. PanM.
[Graphical view]
PfamiPF12568. DUF3749. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPANM_ECOLI
AccessioniPrimary (citable) accession number: P37613
Secondary accession number(s): Q2M7C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Lacks the conserved catalytic glutamate found in many enzymatically active members of the Gcn5-like N-acetyltransferase (GNAT) family.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.