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Protein

Inner membrane transport protein YdhC

Gene

ydhC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:YDHC-MONOMER

Protein family/group databases

TCDBi2.A.1.2.62 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane transport protein YdhC
Gene namesi
Name:ydhC
Ordered Locus Names:b1660, JW1652
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12141 ydhC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 41PeriplasmicSequence analysisAdd BLAST14
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 71CytoplasmicSequence analysis9
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Topological domaini93 – 94PeriplasmicSequence analysis2
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 134CytoplasmicSequence analysisAdd BLAST19
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 159PeriplasmicSequence analysis4
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 208CytoplasmicSequence analysisAdd BLAST28
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 237PeriplasmicSequence analysis8
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 270CytoplasmicSequence analysisAdd BLAST12
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 298PeriplasmicSequence analysis7
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 340CytoplasmicSequence analysisAdd BLAST21
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 403CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734011 – 403Inner membrane transport protein YdhCAdd BLAST403

Proteomic databases

PaxDbiP37597
PRIDEiP37597

Interactioni

Protein-protein interaction databases

BioGridi4261211, 154 interactors
STRINGi316385.ECDH10B_1794

Structurei

3D structure databases

ProteinModelPortaliP37597
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CZQ Bacteria
ENOG410XPCY LUCA
HOGENOMiHOG000143172
InParanoidiP37597
OMAiNIARFFQ
PhylomeDBiP37597

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004812 Efflux_drug-R_Bcr/CmlA
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00710 efflux_Bcr_CflA, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P37597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPGKRFLVW LAGLSVLGFL ATDMYLPAFA AIQADLQTPA SAVSASLSLF
60 70 80 90 100
LAGFAAAQLL WGPLSDRYGR KPVLLIGLTI FALGSLGMLW VENAATLLVL
110 120 130 140 150
RFVQAVGVCA AAVIWQALVT DYYPSQKVNR IFAAIMPLVG LSPALAPLLG
160 170 180 190 200
SWLLVHFSWQ AIFATLFAIT VVLILPIFWL KPTTKARNNS QDGLTFTDLL
210 220 230 240 250
RSKTYRGNVL IYAACSASFF AWLTGSPFIL SEMGYSPAVI GLSYVPQTIA
260 270 280 290 300
FLIGGYGCRA ALQKWQGKQL LPWLLVLFAV SVIATWAAGF ISHVSLVEIL
310 320 330 340 350
IPFCVMAIAN GAIYPIVVAQ ALRPFPHATG RAAALQNTLQ LGLCFLASLV
360 370 380 390 400
VSWLISISTP LLTTTSVMLS TVVLVALGYM MQRCEEVGCQ NHGNAEVAHS

ESH
Length:403
Mass (Da):43,367
Last modified:October 11, 2004 - v3
Checksum:i3A046AA46D4781B8
GO

Sequence cautioni

The sequence X69109 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35D → E in X69109 (Ref. 1) Curated1
Sequence conflicti55A → T (Ref. 1) Curated1
Sequence conflicti69G → V (Ref. 1) Curated1
Sequence conflicti145L → M (Ref. 1) Curated1
Sequence conflicti149L → I (Ref. 1) Curated1
Sequence conflicti169I → K (Ref. 1) Curated1
Sequence conflicti210 – 212LIY → MKH (Ref. 1) Curated3
Sequence conflicti235Y → N (Ref. 1) Curated1
Sequence conflicti260A → P (Ref. 1) Curated1
Sequence conflicti291 – 305ISHVS…IPFCV → NNAXVS (Ref. 1) CuratedAdd BLAST15
Sequence conflicti335L → M (Ref. 1) Curated1
Sequence conflicti384 – 403CEEVG…HSESH → RIIDSRFFLRDFSQSPKSVY AVLRF (Ref. 1) CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69109 Genomic DNA No translation available.
U00096 Genomic DNA Translation: AAT48135.1
AP009048 Genomic DNA Translation: BAA15426.1
PIRiF64923
RefSeqiWP_001182347.1, NZ_LN832404.1
YP_025306.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48135; AAT48135; b1660
BAA15426; BAA15426; BAA15426
GeneIDi946077
KEGGiecj:JW1652
eco:b1660
PATRICifig|1411691.4.peg.597

Similar proteinsi

Entry informationi

Entry nameiYDHC_ECOLI
AccessioniPrimary (citable) accession number: P37597
Secondary accession number(s): P76191, P77477
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health