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P37597 (YDHC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inner membrane transport protein YdhC
Gene names
Name:ydhC
Ordered Locus Names:b1660, JW1652
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the major facilitator superfamily. Bcr/CmlA family.

Sequence caution

The sequence X69109 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403Inner membrane transport protein YdhC
PRO_0000173401

Regions

Topological domain1 – 66Cytoplasmic Potential
Transmembrane7 – 2721Helical; Potential
Topological domain28 – 4114Periplasmic Potential
Transmembrane42 – 6221Helical; Potential
Topological domain63 – 719Cytoplasmic Potential
Transmembrane72 – 9221Helical; Potential
Topological domain93 – 942Periplasmic Potential
Transmembrane95 – 11521Helical; Potential
Topological domain116 – 13419Cytoplasmic Potential
Transmembrane135 – 15521Helical; Potential
Topological domain156 – 1594Periplasmic Potential
Transmembrane160 – 18021Helical; Potential
Topological domain181 – 20828Cytoplasmic Potential
Transmembrane209 – 22921Helical; Potential
Topological domain230 – 2378Periplasmic Potential
Transmembrane238 – 25821Helical; Potential
Topological domain259 – 27012Cytoplasmic Potential
Transmembrane271 – 29121Helical; Potential
Topological domain292 – 2987Periplasmic Potential
Transmembrane299 – 31921Helical; Potential
Topological domain320 – 34021Cytoplasmic Potential
Transmembrane341 – 36121Helical; Potential
Transmembrane362 – 38221Helical; Potential
Topological domain383 – 40321Cytoplasmic Potential

Experimental info

Sequence conflict351D → E in X69109. Ref.1
Sequence conflict551A → T Ref.1
Sequence conflict691G → V Ref.1
Sequence conflict1451L → M Ref.1
Sequence conflict1491L → I Ref.1
Sequence conflict1691I → K Ref.1
Sequence conflict210 – 2123LIY → MKH Ref.1
Sequence conflict2351Y → N Ref.1
Sequence conflict2601A → P Ref.1
Sequence conflict291 – 30515ISHVS…IPFCV → NNAXVS Ref.1
Sequence conflict3351L → M Ref.1
Sequence conflict384 – 40320CEEVG…HSESH → RIIDSRFFLRDFSQSPKSVY AVLRF Ref.1

Sequences

Sequence LengthMass (Da)Tools
P37597 [UniParc].

Last modified October 11, 2004. Version 3.
Checksum: 3A046AA46D4781B8

FASTA40343,367
        10         20         30         40         50         60 
MQPGKRFLVW LAGLSVLGFL ATDMYLPAFA AIQADLQTPA SAVSASLSLF LAGFAAAQLL 

        70         80         90        100        110        120 
WGPLSDRYGR KPVLLIGLTI FALGSLGMLW VENAATLLVL RFVQAVGVCA AAVIWQALVT 

       130        140        150        160        170        180 
DYYPSQKVNR IFAAIMPLVG LSPALAPLLG SWLLVHFSWQ AIFATLFAIT VVLILPIFWL 

       190        200        210        220        230        240 
KPTTKARNNS QDGLTFTDLL RSKTYRGNVL IYAACSASFF AWLTGSPFIL SEMGYSPAVI 

       250        260        270        280        290        300 
GLSYVPQTIA FLIGGYGCRA ALQKWQGKQL LPWLLVLFAV SVIATWAAGF ISHVSLVEIL 

       310        320        330        340        350        360 
IPFCVMAIAN GAIYPIVVAQ ALRPFPHATG RAAALQNTLQ LGLCFLASLV VSWLISISTP 

       370        380        390        400 
LLTTTSVMLS TVVLVALGYM MQRCEEVGCQ NHGNAEVAHS ESH

« Hide

References

« Hide 'large scale' references
[1]Eberhardt S.M.R., Richter G., Gimbel W., Werner T., Bacher A.
Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12 / RR28.
[2]"A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map."
Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T., Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K. expand/collapse author list , Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T.
DNA Res. 3:363-377(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005."
Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R., Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T., Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H., Thomson N.R., Wishart D., Wanner B.L.
Nucleic Acids Res. 34:1-9(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 373.
[5]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]Rudd K.E.
Unpublished observations (FEB-1994)
Cited for: IDENTIFICATION.
[7]"Global topology analysis of the Escherichia coli inner membrane proteome."
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X69109 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: AAT48135.1.
AP009048 Genomic DNA. Translation: BAA15426.1.
PIRF64923.
RefSeqYP_025306.1. NC_000913.2.
YP_489924.1. NC_007779.1.

3D structure databases

ProteinModelPortalP37597.
SMRP37597. Positions 18-349.
ModBaseSearch...

Protein-protein interaction databases

STRING511145.b1660.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT48135; AAT48135; b1660.
BAA15426; BAA15426; BAA15426.
GeneID12932217.
946077.
KEGGecj:Y75_p1637.
eco:b1660.
PATRIC32118626. VBIEscCol129921_1733.

Organism-specific databases

EchoBASEEB2062.
EcoGeneEG12141. ydhC.

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000143172.
OMAHTHSEHA.
ProtClustDBPRK11043.

Enzyme and pathway databases

BioCycEcoCyc:YDHC-MONOMER.
ECOL316407:JW1652-MONOMER.

Gene expression databases

GenevestigatorP37597.

Family and domain databases

InterProIPR004812. Efflux_drug-R_Bcr_CflA.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR00710. efflux_Bcr_CflA. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameYDHC_ECOLI
AccessionPrimary (citable) accession number: P37597
Secondary accession number(s): P76191, P77477
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 11, 2004
Last modified: May 1, 2013
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents