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Protein

Inner membrane transport protein YdhC

Gene

ydhC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:YDHC-MONOMER.
ECOL316407:JW1652-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.62. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane transport protein YdhC
Gene namesi
Name:ydhC
Ordered Locus Names:b1660, JW1652
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12141. ydhC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 41PeriplasmicSequence analysisAdd BLAST14
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 71CytoplasmicSequence analysis9
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Topological domaini93 – 94PeriplasmicSequence analysis2
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 134CytoplasmicSequence analysisAdd BLAST19
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 159PeriplasmicSequence analysis4
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 208CytoplasmicSequence analysisAdd BLAST28
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 237PeriplasmicSequence analysis8
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 270CytoplasmicSequence analysisAdd BLAST12
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 298PeriplasmicSequence analysis7
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 340CytoplasmicSequence analysisAdd BLAST21
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 403CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734011 – 403Inner membrane transport protein YdhCAdd BLAST403

Proteomic databases

PaxDbiP37597.
PRIDEiP37597.

Interactioni

Protein-protein interaction databases

BioGridi4261211. 154 interactors.
STRINGi511145.b1660.

Structurei

3D structure databases

ProteinModelPortaliP37597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CZQ. Bacteria.
ENOG410XPCY. LUCA.
HOGENOMiHOG000143172.
InParanoidiP37597.
OMAiFKIAIAR.
PhylomeDBiP37597.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004812. Efflux_drug-R_Bcr/CmlA.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00710. efflux_Bcr_CflA. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPGKRFLVW LAGLSVLGFL ATDMYLPAFA AIQADLQTPA SAVSASLSLF
60 70 80 90 100
LAGFAAAQLL WGPLSDRYGR KPVLLIGLTI FALGSLGMLW VENAATLLVL
110 120 130 140 150
RFVQAVGVCA AAVIWQALVT DYYPSQKVNR IFAAIMPLVG LSPALAPLLG
160 170 180 190 200
SWLLVHFSWQ AIFATLFAIT VVLILPIFWL KPTTKARNNS QDGLTFTDLL
210 220 230 240 250
RSKTYRGNVL IYAACSASFF AWLTGSPFIL SEMGYSPAVI GLSYVPQTIA
260 270 280 290 300
FLIGGYGCRA ALQKWQGKQL LPWLLVLFAV SVIATWAAGF ISHVSLVEIL
310 320 330 340 350
IPFCVMAIAN GAIYPIVVAQ ALRPFPHATG RAAALQNTLQ LGLCFLASLV
360 370 380 390 400
VSWLISISTP LLTTTSVMLS TVVLVALGYM MQRCEEVGCQ NHGNAEVAHS

ESH
Length:403
Mass (Da):43,367
Last modified:October 11, 2004 - v3
Checksum:i3A046AA46D4781B8
GO

Sequence cautioni

The sequence X69109 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35D → E in X69109 (Ref. 1) Curated1
Sequence conflicti55A → T (Ref. 1) Curated1
Sequence conflicti69G → V (Ref. 1) Curated1
Sequence conflicti145L → M (Ref. 1) Curated1
Sequence conflicti149L → I (Ref. 1) Curated1
Sequence conflicti169I → K (Ref. 1) Curated1
Sequence conflicti210 – 212LIY → MKH (Ref. 1) Curated3
Sequence conflicti235Y → N (Ref. 1) Curated1
Sequence conflicti260A → P (Ref. 1) Curated1
Sequence conflicti291 – 305ISHVS…IPFCV → NNAXVS (Ref. 1) CuratedAdd BLAST15
Sequence conflicti335L → M (Ref. 1) Curated1
Sequence conflicti384 – 403CEEVG…HSESH → RIIDSRFFLRDFSQSPKSVY AVLRF (Ref. 1) CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69109 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: AAT48135.1.
AP009048 Genomic DNA. Translation: BAA15426.1.
PIRiF64923.
RefSeqiWP_001182347.1. NZ_LN832404.1.
YP_025306.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48135; AAT48135; b1660.
BAA15426; BAA15426; BAA15426.
GeneIDi946077.
KEGGiecj:JW1652.
eco:b1660.
PATRICi32118626. VBIEscCol129921_1733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69109 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: AAT48135.1.
AP009048 Genomic DNA. Translation: BAA15426.1.
PIRiF64923.
RefSeqiWP_001182347.1. NZ_LN832404.1.
YP_025306.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP37597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261211. 154 interactors.
STRINGi511145.b1660.

Protein family/group databases

TCDBi2.A.1.2.62. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP37597.
PRIDEiP37597.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48135; AAT48135; b1660.
BAA15426; BAA15426; BAA15426.
GeneIDi946077.
KEGGiecj:JW1652.
eco:b1660.
PATRICi32118626. VBIEscCol129921_1733.

Organism-specific databases

EchoBASEiEB2062.
EcoGeneiEG12141. ydhC.

Phylogenomic databases

eggNOGiENOG4105CZQ. Bacteria.
ENOG410XPCY. LUCA.
HOGENOMiHOG000143172.
InParanoidiP37597.
OMAiFKIAIAR.
PhylomeDBiP37597.

Enzyme and pathway databases

BioCyciEcoCyc:YDHC-MONOMER.
ECOL316407:JW1652-MONOMER.

Miscellaneous databases

PROiP37597.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004812. Efflux_drug-R_Bcr/CmlA.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00710. efflux_Bcr_CflA. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYDHC_ECOLI
AccessioniPrimary (citable) accession number: P37597
Secondary accession number(s): P76191, P77477
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.