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Protein

Methyl viologen resistance protein SmvA

Gene

smvA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Major efflux pump for acriflavine and other quaternary ammonium compounds (QACs). Also required for resistance to methyl viologen (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1584-MONOMER.

Protein family/group databases

TCDBi2.A.1.3.14. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl viologen resistance protein SmvA
Gene namesi
Name:smvA
Ordered Locus Names:STM1574
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Transmembranei44 – 6421HelicalSequence analysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence analysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence analysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence analysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence analysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence analysisAdd
BLAST
Transmembranei299 – 31921HelicalSequence analysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence analysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence analysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence analysisAdd
BLAST
Transmembranei469 – 48921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Methyl viologen resistance protein SmvAPRO_0000173381Add
BLAST

Proteomic databases

PaxDbiP37594.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1574.

Structurei

3D structure databases

ProteinModelPortaliP37594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C57. Bacteria.
COG0477. LUCA.
HOGENOMiHOG000239124.
KOiK08167.
OMAiIRSTFAE.
OrthoDBiEOG6K6V9J.
PhylomeDBiP37594.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37594-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRQWLTLVI IVLVYIPVAI DATVLHVAAP TLSMTLGASG NELLWIIDIY
60 70 80 90 100
SLVMAGMVLP MGALGDRIGF KRLLMLGGTL FGLASLAAAF SHTASWLIAT
110 120 130 140 150
RVLLAIGAAM IVPATLAGIR ATFCEEKHRN MALGVWAAVG SGGAAFGPLI
160 170 180 190 200
GGILLEHFYW GSVFLINVPI VLVVMGLTAR YVPRQAGRRD QPLNLGHAVM
210 220 230 240 250
LIIAILLLVY SAKTALKGHL SLWVISFTLL TGALLLGLFI RTQLATSRPM
260 270 280 290 300
IDMRLFTHRI ILSGVVMAMT AMITLVGFEL LMAQELQFVH GLSPYEAGVF
310 320 330 340 350
MLPVMVASGF SGPIAGVLVS RLGLRLVATG GMALSALSFY GLAMTDFSTQ
360 370 380 390 400
QWQAWGLMAL LGFSAASALL ASTSAIMAAA PAEKAAAAGA IETMAYELGA
410 420 430 440 450
GLGIAIFGLL LSRSFSASIR LPAGLEAQEI ARASSSMGEA VQLANSLPPT
460 470 480 490
QGQAILDAAR HAFIWSHSVA LSSAGSMLLL LAVGMWFSLA KAQRR
Length:495
Mass (Da):52,134
Last modified:January 23, 2002 - v2
Checksum:i961F77C748CDA164
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1441A → R in BAA05055 (PubMed:7926834).Curated
Sequence conflicti147 – 1471G → V in BAA05055 (PubMed:7926834).Curated
Sequence conflicti182 – 1821V → D in BAA05055 (PubMed:7926834).Curated
Sequence conflicti198 – 1981A → V in BAA05055 (PubMed:7926834).Curated
Sequence conflicti227 – 2271F → Y in BAA05055 (PubMed:7926834).Curated
Sequence conflicti447 – 4471L → Y in BAA05055 (PubMed:7926834).Curated
Sequence conflicti454 – 4574AILD → GKYLT in BAA05055 (PubMed:7926834).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26057 Genomic DNA. Translation: BAA05055.1.
AE006468 Genomic DNA. Translation: AAL20492.1.
RefSeqiNP_460533.1. NC_003197.1.
WP_000489731.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20492; AAL20492; STM1574.
GeneIDi1253092.
KEGGistm:STM1574.
PATRICi32381650. VBISalEnt20916_1665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26057 Genomic DNA. Translation: BAA05055.1.
AE006468 Genomic DNA. Translation: AAL20492.1.
RefSeqiNP_460533.1. NC_003197.1.
WP_000489731.1. NC_003197.1.

3D structure databases

ProteinModelPortaliP37594.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1574.

Protein family/group databases

TCDBi2.A.1.3.14. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP37594.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20492; AAL20492; STM1574.
GeneIDi1253092.
KEGGistm:STM1574.
PATRICi32381650. VBISalEnt20916_1665.

Phylogenomic databases

eggNOGiENOG4105C57. Bacteria.
COG0477. LUCA.
HOGENOMiHOG000239124.
KOiK08167.
OMAiIRSTFAE.
OrthoDBiEOG6K6V9J.
PhylomeDBiP37594.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1584-MONOMER.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The methyl viologen-resistance-encoding gene smvA of Salmonella typhimurium."
    Hongo E., Morimyo M., Mita K., Machida I., Hama-Inaba H., Tsuji H., Ichimura S., Noda Y.
    Gene 148:173-174(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SL1303.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiSMVA_SALTY
AccessioniPrimary (citable) accession number: P37594
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2002
Last modified: November 11, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.