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Protein

Signal transduction protein PmrD

Gene

pmrD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance in some natural isolates.1 Publication

Caution

The PmrD protein from K12 strain (sequence shown) does not interact with phosphorylated BasR protein, and thus does not seem to be involved in polymyxin resistance.Curated

GO - Biological processi

Keywordsi

Biological processAntibiotic resistance

Enzyme and pathway databases

BioCyciEcoCyc:G7172-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transduction protein PmrD
Alternative name(s):
BasR post-transcriptional activator
Polymyxin resistance protein PmrD
Gene namesi
Name:pmrD
Ordered Locus Names:b2259, JW2254
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12671 pmrD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584681 – 88Signal transduction protein PmrDAdd BLAST88

Proteomic databases

PaxDbiP37590
PRIDEiP37590

Expressioni

Inductioni

By PhoP.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260491, 9 interactors
IntActiP37590, 8 interactors
STRINGi316385.ECDH10B_2420

Structurei

Secondary structure

188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 9Combined sources7
Beta strandi12 – 23Combined sources12
Beta strandi29 – 35Combined sources7
Beta strandi45 – 50Combined sources6
Beta strandi53 – 56Combined sources4
Beta strandi59 – 71Combined sources13
Helixi74 – 84Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JSONMR-A1-88[»]
4HN7X-ray2.35A1-88[»]
ProteinModelPortaliP37590
SMRiP37590
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37590

Family & Domainsi

Sequence similaritiesi

Belongs to the PmrD family.Curated

Phylogenomic databases

eggNOGiENOG4106GZG Bacteria
ENOG410Y1Y0 LUCA
KOiK19238
OMAiWWVKKVR

Family and domain databases

Gene3Di2.40.50.650, 1 hit
InterProiView protein in InterPro
IPR038679 PmrD_sf
IPR020146 Sig_transdc_PmrD
ProDomiView protein in ProDom or Entries sharing at least one domain
PD028730 Sig_transdc_PmrD, 1 hit

Sequencei

Sequence statusi: Complete.

P37590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWLVKKSCC NKQDNRHVLM LCDAGGAIKM IAEVKSDFAV KVGDLLSPLQ
60 70 80
NALYCINREK LHTVKVLSAS SYSPDEWERQ CKVAGKTQ
Length:88
Mass (Da):9,871
Last modified:November 1, 1997 - v2
Checksum:i0DE537EAEE5784EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88Q → QYVVLSWAGKSASTRS in L35031 (PubMed:8626063).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti11N → D in strain: ECOR 46, ECOR 48, ECOR 49 and O2:HN / ECOR 50 / P97 / UPEC. 1
Natural varianti14D → N in strain: ECOR 53, ECOR 59 and ECOR 60. 1
Natural varianti19L → I in strain: ECOR 23, ECOR 32, ECOR 38, ECOR 39, ECOR 40, ECOR 41, ECOR 51, ECOR 52, ECOR 54, ECOR 55, ECOR 56, ECOR 57, ECOR 61, ECOR 62, ECOR 63, ECOR 64, ECOR 65 and ECOR 66. 1
Natural varianti20M → K in strain: ECOR 46, ECOR 49 and O2:HN / ECOR 50 / P97 / UPEC. 1
Natural varianti27A → T in strain: ECOR 46, ECOR 48, ECOR 49 and O2:HN / ECOR 50 / P97 / UPEC. 1
Natural varianti71S → C in strain: ECOR 38, ECOR 39, ECOR 41, ECOR 51, ECOR 52, ECOR 53, ECOR 54, ECOR 55, ECOR 56, ECOR 61, ECOR 63, ECOR 64, ECOR 65 and ECOR 66. 1
Natural varianti81C → S in strain: ECOR 53, ECOR 59 and ECOR 60. 1
Natural varianti82K → T in strain: ECOR 26, ECOR 27, ECOR 29, ECOR 30, ECOR 33, ECOR 44, ECOR 45, ECOR 47, ECOR 58, ECOR 67, ECOR 68, ECOR 69 and ECOR 71. 1
Natural varianti83V → A in strain: ECOR 27, ECOR 33, ECOR 38, ECOR 39, ECOR 41, ECOR 44, ECOR 45, ECOR 47, ECOR 51, ECOR 52, ECOR 53, ECOR 54, ECOR 55, ECOR 56, ECOR 57, ECOR 59, ECOR 60, ECOR 61, ECOR 63, ECOR 64, ECOR 65, ECOR 66 and ECOR 69. 1
Natural varianti84A → E in strain: ECOR 28 and ECOR 30. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35031 Genomic DNA No translation available.
AY725349 Genomic DNA Translation: AAV92796.1
AY725350 Genomic DNA Translation: AAV92797.1
AY725351 Genomic DNA Translation: AAV92798.1
AY725352 Genomic DNA Translation: AAV92799.1
AY725353 Genomic DNA Translation: AAV92800.1
AY725354 Genomic DNA Translation: AAV92801.1
AY725355 Genomic DNA Translation: AAV92802.1
AY725356 Genomic DNA Translation: AAV92803.1
AY725357 Genomic DNA Translation: AAV92804.1
AY725358 Genomic DNA Translation: AAV92805.1
AY725359 Genomic DNA Translation: AAV92806.1
AY725360 Genomic DNA Translation: AAV92807.1
AY725361 Genomic DNA Translation: AAV92808.1
AY725362 Genomic DNA Translation: AAV92809.1
AY725363 Genomic DNA Translation: AAV92810.1
AY725364 Genomic DNA Translation: AAV92811.1
AY725365 Genomic DNA Translation: AAV92812.1
AY725366 Genomic DNA Translation: AAV92813.1
AY725367 Genomic DNA Translation: AAV92814.1
AY725368 Genomic DNA Translation: AAV92815.1
AY725369 Genomic DNA Translation: AAV92816.1
AY725370 Genomic DNA Translation: AAV92817.1
AY725371 Genomic DNA Translation: AAV92818.1
AY725372 Genomic DNA Translation: AAV92819.1
AY725373 Genomic DNA Translation: AAV92820.1
AY725374 Genomic DNA Translation: AAV92821.1
AY725375 Genomic DNA Translation: AAV92822.1
AY725376 Genomic DNA Translation: AAV92823.1
AY725377 Genomic DNA Translation: AAV92824.1
AY725378 Genomic DNA Translation: AAV92825.1
AY725379 Genomic DNA Translation: AAV92826.1
AY725380 Genomic DNA Translation: AAV92827.1
AY725381 Genomic DNA Translation: AAV92828.1
AY725382 Genomic DNA Translation: AAV92829.1
AY725383 Genomic DNA Translation: AAV92830.1
AY725384 Genomic DNA Translation: AAV92831.1
AY725385 Genomic DNA Translation: AAV92832.1
AY725386 Genomic DNA Translation: AAV92833.1
AY725387 Genomic DNA Translation: AAV92834.1
AY725388 Genomic DNA Translation: AAV92835.1
AY725389 Genomic DNA Translation: AAV92836.1
AY725390 Genomic DNA Translation: AAV92837.1
AY725391 Genomic DNA Translation: AAV92838.1
AY725392 Genomic DNA Translation: AAV92839.1
AY725393 Genomic DNA Translation: AAV92840.1
AY725394 Genomic DNA Translation: AAV92841.1
AY725395 Genomic DNA Translation: AAV92842.1
AY725396 Genomic DNA Translation: AAV92843.1
AY725397 Genomic DNA Translation: AAV92844.1
AY725398 Genomic DNA Translation: AAV92845.1
AY725399 Genomic DNA Translation: AAV92846.1
AY725400 Genomic DNA Translation: AAV92847.1
AY725401 Genomic DNA Translation: AAV92848.1
AY725402 Genomic DNA Translation: AAV92849.1
AY725403 Genomic DNA Translation: AAV92850.1
AY725404 Genomic DNA Translation: AAV92851.1
AY725405 Genomic DNA Translation: AAV92852.1
AY725406 Genomic DNA Translation: AAV92853.1
AY725407 Genomic DNA Translation: AAV92854.1
AY725408 Genomic DNA Translation: AAV92855.1
AY725409 Genomic DNA Translation: AAV92856.1
AY725410 Genomic DNA Translation: AAV92857.1
AY725411 Genomic DNA Translation: AAV92858.1
AY725412 Genomic DNA Translation: AAV92859.1
AY725413 Genomic DNA Translation: AAV92860.1
AY725414 Genomic DNA Translation: AAV92861.1
AY725415 Genomic DNA Translation: AAV92862.1
AY725416 Genomic DNA Translation: AAV92863.1
AY725417 Genomic DNA Translation: AAV92864.1
AY725418 Genomic DNA Translation: AAV92865.1
AY725419 Genomic DNA Translation: AAV92866.1
U00096 Genomic DNA Translation: AAC75319.2
AP009048 Genomic DNA Translation: BAA16079.2
PIRiA64997
RefSeqiNP_416762.2, NC_000913.3
WP_001295285.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75319; AAC75319; b2259
BAA16079; BAA16079; BAA16079
GeneIDi945130
KEGGiecj:JW2254
eco:b2259
PATRICifig|511145.12.peg.2352

Entry informationi

Entry nameiPMRD_ECOLI
AccessioniPrimary (citable) accession number: P37590
Secondary accession number(s): P76475
, P77155, Q5MN33, Q5MN36, Q5MN40, Q5MN44, Q5MN45, Q5MN54, Q5MN59, Q5MN60, Q5MN62, Q5MN63, Q5MN64, Q5MN90, Q8KJP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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