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Protein

Signal transduction protein PmrD

Gene

pmrD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance in some natural isolates.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciEcoCyc:G7172-MONOMER.
ECOL316407:JW2254-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transduction protein PmrD
Alternative name(s):
BasR post-transcriptional activator
Polymyxin resistance protein PmrD
Gene namesi
Name:pmrD
Ordered Locus Names:b2259, JW2254
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12671. pmrD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8888Signal transduction protein PmrDPRO_0000058468Add
BLAST

Proteomic databases

PaxDbiP37590.
PRIDEiP37590.

Expressioni

Inductioni

By PhoP.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260491. 9 interactions.
IntActiP37590. 9 interactions.
STRINGi511145.b2259.

Structurei

Secondary structure

1
88
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 97Combined sources
Beta strandi12 – 2312Combined sources
Beta strandi29 – 357Combined sources
Beta strandi45 – 506Combined sources
Beta strandi53 – 564Combined sources
Beta strandi59 – 7113Combined sources
Helixi74 – 8411Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JSONMR-A1-88[»]
4HN7X-ray2.35A1-88[»]
ProteinModelPortaliP37590.
SMRiP37590. Positions 1-88.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37590.

Family & Domainsi

Sequence similaritiesi

Belongs to the PmrD family.Curated

Phylogenomic databases

eggNOGiENOG4106GZG. Bacteria.
ENOG410Y1Y0. LUCA.
KOiK19238.
OMAiQDNTMEW.

Family and domain databases

InterProiIPR020146. Sig_transdc_PmrD.
[Graphical view]
ProDomiPD028730. Sig_transdc_PmrD. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P37590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWLVKKSCC NKQDNRHVLM LCDAGGAIKM IAEVKSDFAV KVGDLLSPLQ
60 70 80
NALYCINREK LHTVKVLSAS SYSPDEWERQ CKVAGKTQ
Length:88
Mass (Da):9,871
Last modified:November 1, 1997 - v2
Checksum:i0DE537EAEE5784EF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881Q → QYVVLSWAGKSASTRS in L35031 (PubMed:8626063).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111N → D in strain: ECOR 46, ECOR 48, ECOR 49 and O2:HN / ECOR 50 / P97 / UPEC.
Natural varianti14 – 141D → N in strain: ECOR 53, ECOR 59 and ECOR 60.
Natural varianti19 – 191L → I in strain: ECOR 23, ECOR 32, ECOR 38, ECOR 39, ECOR 40, ECOR 41, ECOR 51, ECOR 52, ECOR 54, ECOR 55, ECOR 56, ECOR 57, ECOR 61, ECOR 62, ECOR 63, ECOR 64, ECOR 65 and ECOR 66.
Natural varianti20 – 201M → K in strain: ECOR 46, ECOR 49 and O2:HN / ECOR 50 / P97 / UPEC.
Natural varianti27 – 271A → T in strain: ECOR 46, ECOR 48, ECOR 49 and O2:HN / ECOR 50 / P97 / UPEC.
Natural varianti71 – 711S → C in strain: ECOR 38, ECOR 39, ECOR 41, ECOR 51, ECOR 52, ECOR 53, ECOR 54, ECOR 55, ECOR 56, ECOR 61, ECOR 63, ECOR 64, ECOR 65 and ECOR 66.
Natural varianti81 – 811C → S in strain: ECOR 53, ECOR 59 and ECOR 60.
Natural varianti82 – 821K → T in strain: ECOR 26, ECOR 27, ECOR 29, ECOR 30, ECOR 33, ECOR 44, ECOR 45, ECOR 47, ECOR 58, ECOR 67, ECOR 68, ECOR 69 and ECOR 71.
Natural varianti83 – 831V → A in strain: ECOR 27, ECOR 33, ECOR 38, ECOR 39, ECOR 41, ECOR 44, ECOR 45, ECOR 47, ECOR 51, ECOR 52, ECOR 53, ECOR 54, ECOR 55, ECOR 56, ECOR 57, ECOR 59, ECOR 60, ECOR 61, ECOR 63, ECOR 64, ECOR 65, ECOR 66 and ECOR 69.
Natural varianti84 – 841A → E in strain: ECOR 28 and ECOR 30.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35031 Genomic DNA. No translation available.
AY725349 Genomic DNA. Translation: AAV92796.1.
AY725350 Genomic DNA. Translation: AAV92797.1.
AY725351 Genomic DNA. Translation: AAV92798.1.
AY725352 Genomic DNA. Translation: AAV92799.1.
AY725353 Genomic DNA. Translation: AAV92800.1.
AY725354 Genomic DNA. Translation: AAV92801.1.
AY725355 Genomic DNA. Translation: AAV92802.1.
AY725356 Genomic DNA. Translation: AAV92803.1.
AY725357 Genomic DNA. Translation: AAV92804.1.
AY725358 Genomic DNA. Translation: AAV92805.1.
AY725359 Genomic DNA. Translation: AAV92806.1.
AY725360 Genomic DNA. Translation: AAV92807.1.
AY725361 Genomic DNA. Translation: AAV92808.1.
AY725362 Genomic DNA. Translation: AAV92809.1.
AY725363 Genomic DNA. Translation: AAV92810.1.
AY725364 Genomic DNA. Translation: AAV92811.1.
AY725365 Genomic DNA. Translation: AAV92812.1.
AY725366 Genomic DNA. Translation: AAV92813.1.
AY725367 Genomic DNA. Translation: AAV92814.1.
AY725368 Genomic DNA. Translation: AAV92815.1.
AY725369 Genomic DNA. Translation: AAV92816.1.
AY725370 Genomic DNA. Translation: AAV92817.1.
AY725371 Genomic DNA. Translation: AAV92818.1.
AY725372 Genomic DNA. Translation: AAV92819.1.
AY725373 Genomic DNA. Translation: AAV92820.1.
AY725374 Genomic DNA. Translation: AAV92821.1.
AY725375 Genomic DNA. Translation: AAV92822.1.
AY725376 Genomic DNA. Translation: AAV92823.1.
AY725377 Genomic DNA. Translation: AAV92824.1.
AY725378 Genomic DNA. Translation: AAV92825.1.
AY725379 Genomic DNA. Translation: AAV92826.1.
AY725380 Genomic DNA. Translation: AAV92827.1.
AY725381 Genomic DNA. Translation: AAV92828.1.
AY725382 Genomic DNA. Translation: AAV92829.1.
AY725383 Genomic DNA. Translation: AAV92830.1.
AY725384 Genomic DNA. Translation: AAV92831.1.
AY725385 Genomic DNA. Translation: AAV92832.1.
AY725386 Genomic DNA. Translation: AAV92833.1.
AY725387 Genomic DNA. Translation: AAV92834.1.
AY725388 Genomic DNA. Translation: AAV92835.1.
AY725389 Genomic DNA. Translation: AAV92836.1.
AY725390 Genomic DNA. Translation: AAV92837.1.
AY725391 Genomic DNA. Translation: AAV92838.1.
AY725392 Genomic DNA. Translation: AAV92839.1.
AY725393 Genomic DNA. Translation: AAV92840.1.
AY725394 Genomic DNA. Translation: AAV92841.1.
AY725395 Genomic DNA. Translation: AAV92842.1.
AY725396 Genomic DNA. Translation: AAV92843.1.
AY725397 Genomic DNA. Translation: AAV92844.1.
AY725398 Genomic DNA. Translation: AAV92845.1.
AY725399 Genomic DNA. Translation: AAV92846.1.
AY725400 Genomic DNA. Translation: AAV92847.1.
AY725401 Genomic DNA. Translation: AAV92848.1.
AY725402 Genomic DNA. Translation: AAV92849.1.
AY725403 Genomic DNA. Translation: AAV92850.1.
AY725404 Genomic DNA. Translation: AAV92851.1.
AY725405 Genomic DNA. Translation: AAV92852.1.
AY725406 Genomic DNA. Translation: AAV92853.1.
AY725407 Genomic DNA. Translation: AAV92854.1.
AY725408 Genomic DNA. Translation: AAV92855.1.
AY725409 Genomic DNA. Translation: AAV92856.1.
AY725410 Genomic DNA. Translation: AAV92857.1.
AY725411 Genomic DNA. Translation: AAV92858.1.
AY725412 Genomic DNA. Translation: AAV92859.1.
AY725413 Genomic DNA. Translation: AAV92860.1.
AY725414 Genomic DNA. Translation: AAV92861.1.
AY725415 Genomic DNA. Translation: AAV92862.1.
AY725416 Genomic DNA. Translation: AAV92863.1.
AY725417 Genomic DNA. Translation: AAV92864.1.
AY725418 Genomic DNA. Translation: AAV92865.1.
AY725419 Genomic DNA. Translation: AAV92866.1.
U00096 Genomic DNA. Translation: AAC75319.2.
AP009048 Genomic DNA. Translation: BAA16079.2.
PIRiA64997.
RefSeqiNP_416762.2. NC_000913.3.
WP_001295285.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75319; AAC75319; b2259.
BAA16079; BAA16079; BAA16079.
GeneIDi945130.
KEGGiecj:JW2254.
eco:b2259.
PATRICi32119885. VBIEscCol129921_2352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35031 Genomic DNA. No translation available.
AY725349 Genomic DNA. Translation: AAV92796.1.
AY725350 Genomic DNA. Translation: AAV92797.1.
AY725351 Genomic DNA. Translation: AAV92798.1.
AY725352 Genomic DNA. Translation: AAV92799.1.
AY725353 Genomic DNA. Translation: AAV92800.1.
AY725354 Genomic DNA. Translation: AAV92801.1.
AY725355 Genomic DNA. Translation: AAV92802.1.
AY725356 Genomic DNA. Translation: AAV92803.1.
AY725357 Genomic DNA. Translation: AAV92804.1.
AY725358 Genomic DNA. Translation: AAV92805.1.
AY725359 Genomic DNA. Translation: AAV92806.1.
AY725360 Genomic DNA. Translation: AAV92807.1.
AY725361 Genomic DNA. Translation: AAV92808.1.
AY725362 Genomic DNA. Translation: AAV92809.1.
AY725363 Genomic DNA. Translation: AAV92810.1.
AY725364 Genomic DNA. Translation: AAV92811.1.
AY725365 Genomic DNA. Translation: AAV92812.1.
AY725366 Genomic DNA. Translation: AAV92813.1.
AY725367 Genomic DNA. Translation: AAV92814.1.
AY725368 Genomic DNA. Translation: AAV92815.1.
AY725369 Genomic DNA. Translation: AAV92816.1.
AY725370 Genomic DNA. Translation: AAV92817.1.
AY725371 Genomic DNA. Translation: AAV92818.1.
AY725372 Genomic DNA. Translation: AAV92819.1.
AY725373 Genomic DNA. Translation: AAV92820.1.
AY725374 Genomic DNA. Translation: AAV92821.1.
AY725375 Genomic DNA. Translation: AAV92822.1.
AY725376 Genomic DNA. Translation: AAV92823.1.
AY725377 Genomic DNA. Translation: AAV92824.1.
AY725378 Genomic DNA. Translation: AAV92825.1.
AY725379 Genomic DNA. Translation: AAV92826.1.
AY725380 Genomic DNA. Translation: AAV92827.1.
AY725381 Genomic DNA. Translation: AAV92828.1.
AY725382 Genomic DNA. Translation: AAV92829.1.
AY725383 Genomic DNA. Translation: AAV92830.1.
AY725384 Genomic DNA. Translation: AAV92831.1.
AY725385 Genomic DNA. Translation: AAV92832.1.
AY725386 Genomic DNA. Translation: AAV92833.1.
AY725387 Genomic DNA. Translation: AAV92834.1.
AY725388 Genomic DNA. Translation: AAV92835.1.
AY725389 Genomic DNA. Translation: AAV92836.1.
AY725390 Genomic DNA. Translation: AAV92837.1.
AY725391 Genomic DNA. Translation: AAV92838.1.
AY725392 Genomic DNA. Translation: AAV92839.1.
AY725393 Genomic DNA. Translation: AAV92840.1.
AY725394 Genomic DNA. Translation: AAV92841.1.
AY725395 Genomic DNA. Translation: AAV92842.1.
AY725396 Genomic DNA. Translation: AAV92843.1.
AY725397 Genomic DNA. Translation: AAV92844.1.
AY725398 Genomic DNA. Translation: AAV92845.1.
AY725399 Genomic DNA. Translation: AAV92846.1.
AY725400 Genomic DNA. Translation: AAV92847.1.
AY725401 Genomic DNA. Translation: AAV92848.1.
AY725402 Genomic DNA. Translation: AAV92849.1.
AY725403 Genomic DNA. Translation: AAV92850.1.
AY725404 Genomic DNA. Translation: AAV92851.1.
AY725405 Genomic DNA. Translation: AAV92852.1.
AY725406 Genomic DNA. Translation: AAV92853.1.
AY725407 Genomic DNA. Translation: AAV92854.1.
AY725408 Genomic DNA. Translation: AAV92855.1.
AY725409 Genomic DNA. Translation: AAV92856.1.
AY725410 Genomic DNA. Translation: AAV92857.1.
AY725411 Genomic DNA. Translation: AAV92858.1.
AY725412 Genomic DNA. Translation: AAV92859.1.
AY725413 Genomic DNA. Translation: AAV92860.1.
AY725414 Genomic DNA. Translation: AAV92861.1.
AY725415 Genomic DNA. Translation: AAV92862.1.
AY725416 Genomic DNA. Translation: AAV92863.1.
AY725417 Genomic DNA. Translation: AAV92864.1.
AY725418 Genomic DNA. Translation: AAV92865.1.
AY725419 Genomic DNA. Translation: AAV92866.1.
U00096 Genomic DNA. Translation: AAC75319.2.
AP009048 Genomic DNA. Translation: BAA16079.2.
PIRiA64997.
RefSeqiNP_416762.2. NC_000913.3.
WP_001295285.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JSONMR-A1-88[»]
4HN7X-ray2.35A1-88[»]
ProteinModelPortaliP37590.
SMRiP37590. Positions 1-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260491. 9 interactions.
IntActiP37590. 9 interactions.
STRINGi511145.b2259.

Proteomic databases

PaxDbiP37590.
PRIDEiP37590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75319; AAC75319; b2259.
BAA16079; BAA16079; BAA16079.
GeneIDi945130.
KEGGiecj:JW2254.
eco:b2259.
PATRICi32119885. VBIEscCol129921_2352.

Organism-specific databases

EchoBASEiEB2537.
EcoGeneiEG12671. pmrD.

Phylogenomic databases

eggNOGiENOG4106GZG. Bacteria.
ENOG410Y1Y0. LUCA.
KOiK19238.
OMAiQDNTMEW.

Enzyme and pathway databases

BioCyciEcoCyc:G7172-MONOMER.
ECOL316407:JW2254-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP37590.
PROiP37590.

Family and domain databases

InterProiIPR020146. Sig_transdc_PmrD.
[Graphical view]
ProDomiPD028730. Sig_transdc_PmrD. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiPMRD_ECOLI
AccessioniPrimary (citable) accession number: P37590
Secondary accession number(s): P76475
, P77155, Q5MN33, Q5MN36, Q5MN40, Q5MN44, Q5MN45, Q5MN54, Q5MN59, Q5MN60, Q5MN62, Q5MN63, Q5MN64, Q5MN90, Q8KJP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

The PmrD protein from K12 strain (sequence shown) does not interact with phosphorylated BasR protein, and thus does not seem to be involved in polymyxin resistance.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.