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Protein

60 kDa chaperonin 1

Gene

groL1

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperonin 1UniRule annotation
Alternative name(s):
GroEL protein 1UniRule annotation
Protein Cpn60 1UniRule annotation
Gene namesi
Name:groL1UniRule annotation
Synonyms:groE1, groEL-1UniRule annotation, groEL1UniRule annotation
Ordered Locus Names:ML0381
ORF Names:B1620_C3_228, B229_C3_248
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0381.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000634361 – 53760 kDa chaperonin 1Add BLAST537

Proteomic databases

PRIDEiP37578.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0381.

Structurei

3D structure databases

ProteinModelPortaliP37578.
SMRiP37578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiYWIASNA.
OrthoDBiPOG091H00E7.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

P37578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLIEYDET ARHAMEVGMN KLADTVRVTL GPRGRHVVLA KAFGGPTITN
60 70 80 90 100
DGVTVAREID LEDPFENLGA QLVKSVATKT NDVAGDGTTT ATVLAQALVK
110 120 130 140 150
GGLRMVAAGA NPVALGAGIS KAADAVSEAL LAVATPVAGK DAITQVATVS
160 170 180 190 200
SRDEQIGALV GEGMNKVGTD GVVSVEESST LDTELEFTEG VGFDKGFLSA
210 220 230 240 250
YFVTDFDSQQ AVLDDPLVLL HQEKISSLPE LLPMLEKVTE SGKPLLIVAE
260 270 280 290 300
DLEGEALATL VVNSIRKTLK AVAVKSPFFG DRRKAFLEDL AIVTGGQVVN
310 320 330 340 350
PETGLVLREV GTDVLGSARR VVVSKDDTII VDGGGSNDAV AKRVNQLRAE
360 370 380 390 400
IEVSDSEWDR EKLQERVAKL AGGVAVIKVG AVTETALKKR KESVEDAVAA
410 420 430 440 450
AKASIEEGII AGGGSALVQC GAALKQLRTS LTGDEALGID VFFEALKAPL
460 470 480 490 500
YWIATNAGLD GAVVVDKVSG LPAGHGLNAS TLGYGDLVAD GVVDPVKVTR
510 520 530
SAVLNAASVA RMMLTTETAV VDKPAKTEEH DHHGHAH
Length:537
Mass (Da):55,816
Last modified:October 1, 1994 - v1
Checksum:iF2355B1BCFAED50F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11665 Genomic DNA. Translation: CAB62574.1.
U00015 Genomic DNA. Translation: AAC43228.1.
U00020 Genomic DNA. Translation: AAA17312.1.
AL583918 Genomic DNA. Translation: CAC29889.1.
PIRiS25181.
RefSeqiNP_301373.1. NC_002677.1.
WP_010907697.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29889; CAC29889; CAC29889.
GeneIDi909064.
KEGGimle:ML0381.
PATRICifig|272631.5.peg.643.

Similar proteinsi

Entry informationi

Entry nameiCH601_MYCLE
AccessioniPrimary (citable) accession number: P37578
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 27, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families