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Protein

Negative regulator of genetic competence ClpC/MecB

Gene

clpC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi208 – 2158ATPSequence analysis
Nucleotide bindingi545 – 5528ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Repressor

Keywords - Biological processi

Competence, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU00860-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Negative regulator of genetic competence ClpC/MecB
Gene namesi
Name:clpC
Synonyms:mecB
Ordered Locus Names:BSU00860
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 810810Negative regulator of genetic competence ClpC/MecBPRO_0000191228Add
BLAST

Proteomic databases

PaxDbiP37571.
PRIDEiP37571.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
mecAP379588EBI-7349302,EBI-5254676

Protein-protein interaction databases

DIPiDIP-43708N.
IntActiP37571. 5 interactions.
MINTiMINT-2838758.
STRINGi224308.Bsubs1_010100000445.

Structurei

Secondary structure

1
810
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 2316Combined sources
Beta strandi27 – 293Combined sources
Helixi31 – 4111Combined sources
Helixi45 – 528Combined sources
Helixi57 – 6812Combined sources
Helixi82 – 9716Combined sources
Beta strandi101 – 1033Combined sources
Helixi105 – 11511Combined sources
Helixi119 – 1268Combined sources
Helixi131 – 14313Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K77NMR-A1-145[»]
2Y1QX-ray1.50A1-150[»]
2Y1RX-ray2.60A/B/C/D/E/F/G/H1-149[»]
3J3Relectron microscopy9.40A/B/C/D/E/F1-810[»]
3J3Selectron microscopy11.00A/B/C/D/E/F1-810[»]
3J3Telectron microscopy9.00A/B/C/D/E/F1-810[»]
3J3Uelectron microscopy10.00A/B/C/D/E/F1-810[»]
3PXGX-ray3.65A/B/C/D/E/F1-485[»]
3PXIX-ray6.93A/B/C1-810[»]
ProteinModelPortaliP37571.
SMRiP37571. Positions 2-807.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37571.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati19 – 50321Add
BLAST
Repeati93 – 124322Add
BLAST
Domaini417 – 45236UVRPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 1241062 X 32 AA approximate repeatsAdd
BLAST
Regioni163 – 410248IAdd
BLAST
Regioni471 – 662192IIAdd
BLAST

Sequence similaritiesi

Belongs to the ClpA/ClpB family. ClpC subfamily.Curated
Contains 1 UVR domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0542. LUCA.
HOGENOMiHOG000218210.
InParanoidiP37571.
KOiK03696.
OMAiDMGIELS.
OrthoDBiEOG65F8SM.
PhylomeDBiP37571.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
PF02151. UVR. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF81923. SSF81923. 1 hit.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37571-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFGRFTERA QKVLALAQEE ALRLGHNNIG TEHILLGLVR EGEGIAAKAL
60 70 80 90 100
QALGLGSEKI QKEVESLIGR GQEMSQTIHY TPRAKKVIEL SMDEARKLGH
110 120 130 140 150
SYVGTEHILL GLIREGEGVA ARVLNNLGVS LNKARQQVLQ LLGSNETGSS
160 170 180 190 200
AAGTNSNANT PTLDSLARDL TAIAKEDSLD PVIGRSKEIQ RVIEVLSRRT
210 220 230 240 250
KNNPVLIGEP GVGKTAIAEG LAQQIINNEV PEILRDKRVM TLDMGTVVAG
260 270 280 290 300
TKYRGEFEDR LKKVMDEIRQ AGNIILFIDE LHTLIGAGGA EGAIDASNIL
310 320 330 340 350
KPSLARGELQ CIGATTLDEY RKYIEKDAAL ERRFQPIQVD QPSVDESIQI
360 370 380 390 400
LQGLRDRYEA HHRVSITDDA IEAAVKLSDR YISDRFLPDK AIDLIDEAGS
410 420 430 440 450
KVRLRSFTTP PNLKELEQKL DEVRKEKDAA VQSQEFEKAA SLRDTEQRLR
460 470 480 490 500
EQVEDTKKSW KEKQGQENSE VTVDDIAMVV SSWTGVPVSK IAQTETDKLL
510 520 530 540 550
NMENILHSRV IGQDEAVVAV AKAVRRARAG LKDPKRPIGS FIFLGPTGVG
560 570 580 590 600
KTELARALAE SIFGDEESMI RIDMSEYMEK HSTSRLVGSP PGYVGYDEGG
610 620 630 640 650
QLTEKVRRKP YSVVLLDEIE KAHPDVFNIL LQVLEDGRLT DSKGRTVDFR
660 670 680 690 700
NTILIMTSNV GASELKRNKY VGFNVQDETQ NHKDMKDKVM GELKRAFRPE
710 720 730 740 750
FINRIDEIIV FHSLEKKHLT EIVSLMSDQL TKRLKEQDLS IELTDAAKAK
760 770 780 790 800
VAEEGVDLEY GARPLRRAIQ KHVEDRLSEE LLRGNIHKGQ HIVLDVEDGE
810
FVVKTTAKTN
Length:810
Mass (Da):90,119
Last modified:October 1, 1994 - v1
Checksum:i9592231886C2E870
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02604 Genomic DNA. Translation: AAA19233.1.
D26185 Genomic DNA. Translation: BAA05320.1.
AL009126 Genomic DNA. Translation: CAB11862.1.
X75930 Genomic DNA. Translation: CAA53534.1.
PIRiI40508.
RefSeqiNP_387967.1. NC_000964.3.
WP_003235011.1. NZ_JNCM01000029.1.

Genome annotation databases

EnsemblBacteriaiCAB11862; CAB11862; BSU00860.
GeneIDi938481.
KEGGibsu:BSU00860.
PATRICi18971677. VBIBacSub10457_0087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02604 Genomic DNA. Translation: AAA19233.1.
D26185 Genomic DNA. Translation: BAA05320.1.
AL009126 Genomic DNA. Translation: CAB11862.1.
X75930 Genomic DNA. Translation: CAA53534.1.
PIRiI40508.
RefSeqiNP_387967.1. NC_000964.3.
WP_003235011.1. NZ_JNCM01000029.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K77NMR-A1-145[»]
2Y1QX-ray1.50A1-150[»]
2Y1RX-ray2.60A/B/C/D/E/F/G/H1-149[»]
3J3Relectron microscopy9.40A/B/C/D/E/F1-810[»]
3J3Selectron microscopy11.00A/B/C/D/E/F1-810[»]
3J3Telectron microscopy9.00A/B/C/D/E/F1-810[»]
3J3Uelectron microscopy10.00A/B/C/D/E/F1-810[»]
3PXGX-ray3.65A/B/C/D/E/F1-485[»]
3PXIX-ray6.93A/B/C1-810[»]
ProteinModelPortaliP37571.
SMRiP37571. Positions 2-807.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-43708N.
IntActiP37571. 5 interactions.
MINTiMINT-2838758.
STRINGi224308.Bsubs1_010100000445.

Proteomic databases

PaxDbiP37571.
PRIDEiP37571.

Protocols and materials databases

DNASUi938481.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB11862; CAB11862; BSU00860.
GeneIDi938481.
KEGGibsu:BSU00860.
PATRICi18971677. VBIBacSub10457_0087.

Phylogenomic databases

eggNOGiCOG0542. LUCA.
HOGENOMiHOG000218210.
InParanoidiP37571.
KOiK03696.
OMAiDMGIELS.
OrthoDBiEOG65F8SM.
PhylomeDBiP37571.

Enzyme and pathway databases

BioCyciBSUB:BSU00860-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP37571.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
PF02151. UVR. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF81923. SSF81923. 1 hit.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MecB of Bacillus subtilis, a member of the ClpC ATPase family, is a pleiotropic regulator controlling competence gene expression and growth at high temperature."
    Msadek T., Kunst F., Rapoport G.
    Proc. Natl. Acad. Sci. U.S.A. 91:5788-5792(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.
  2. "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin."
    Ogasawara N., Nakai S., Yoshikawa H.
    DNA Res. 1:1-14(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "Stress induction of clpC in Bacillus subtilis and its involvement in stress tolerance."
    Krueger E., Voelker U., Hecker M.
    J. Bacteriol. 176:3360-3367(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 211-387.

Entry informationi

Entry nameiCLPC_BACSU
AccessioniPrimary (citable) accession number: P37571
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: February 17, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.