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P37571 (CLPC_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Negative regulator of genetic competence ClpC/MecB
Gene names
Name:clpC
Synonyms:mecB
Ordered Locus Names:BSU00860
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length810 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK.

Sequence similarities

Belongs to the clpA/clpB family. ClpC subfamily.

Contains 1 UVR domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 810810Negative regulator of genetic competence ClpC/MecB
PRO_0000191228

Regions

Repeat19 – 50321
Repeat93 – 124322
Domain417 – 45236UVR
Nucleotide binding208 – 2158ATP Potential
Nucleotide binding545 – 5528ATP Potential
Region19 – 1241062 X 32 AA approximate repeats
Region163 – 410248I
Region471 – 662192II

Secondary structure

1 ..................... 810
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P37571 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 9592231886C2E870

FASTA81090,119
        10         20         30         40         50         60 
MMFGRFTERA QKVLALAQEE ALRLGHNNIG TEHILLGLVR EGEGIAAKAL QALGLGSEKI 

        70         80         90        100        110        120 
QKEVESLIGR GQEMSQTIHY TPRAKKVIEL SMDEARKLGH SYVGTEHILL GLIREGEGVA 

       130        140        150        160        170        180 
ARVLNNLGVS LNKARQQVLQ LLGSNETGSS AAGTNSNANT PTLDSLARDL TAIAKEDSLD 

       190        200        210        220        230        240 
PVIGRSKEIQ RVIEVLSRRT KNNPVLIGEP GVGKTAIAEG LAQQIINNEV PEILRDKRVM 

       250        260        270        280        290        300 
TLDMGTVVAG TKYRGEFEDR LKKVMDEIRQ AGNIILFIDE LHTLIGAGGA EGAIDASNIL 

       310        320        330        340        350        360 
KPSLARGELQ CIGATTLDEY RKYIEKDAAL ERRFQPIQVD QPSVDESIQI LQGLRDRYEA 

       370        380        390        400        410        420 
HHRVSITDDA IEAAVKLSDR YISDRFLPDK AIDLIDEAGS KVRLRSFTTP PNLKELEQKL 

       430        440        450        460        470        480 
DEVRKEKDAA VQSQEFEKAA SLRDTEQRLR EQVEDTKKSW KEKQGQENSE VTVDDIAMVV 

       490        500        510        520        530        540 
SSWTGVPVSK IAQTETDKLL NMENILHSRV IGQDEAVVAV AKAVRRARAG LKDPKRPIGS 

       550        560        570        580        590        600 
FIFLGPTGVG KTELARALAE SIFGDEESMI RIDMSEYMEK HSTSRLVGSP PGYVGYDEGG 

       610        620        630        640        650        660 
QLTEKVRRKP YSVVLLDEIE KAHPDVFNIL LQVLEDGRLT DSKGRTVDFR NTILIMTSNV 

       670        680        690        700        710        720 
GASELKRNKY VGFNVQDETQ NHKDMKDKVM GELKRAFRPE FINRIDEIIV FHSLEKKHLT 

       730        740        750        760        770        780 
EIVSLMSDQL TKRLKEQDLS IELTDAAKAK VAEEGVDLEY GARPLRRAIQ KHVEDRLSEE 

       790        800        810 
LLRGNIHKGQ HIVLDVEDGE FVVKTTAKTN

« Hide

References

« Hide 'large scale' references
[1]"MecB of Bacillus subtilis, a member of the ClpC ATPase family, is a pleiotropic regulator controlling competence gene expression and growth at high temperature."
Msadek T., Kunst F., Rapoport G.
Proc. Natl. Acad. Sci. U.S.A. 91:5788-5792(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.
[2]"Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin."
Ogasawara N., Nakai S., Yoshikawa H.
DNA Res. 1:1-14(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[4]"Stress induction of clpC in Bacillus subtilis and its involvement in stress tolerance."
Krueger E., Voelker U., Hecker M.
J. Bacteriol. 176:3360-3367(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 211-387.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U02604 Genomic DNA. Translation: AAA19233.1.
D26185 Genomic DNA. Translation: BAA05320.1.
AL009126 Genomic DNA. Translation: CAB11862.1.
X75930 Genomic DNA. Translation: CAA53534.1.
PIRI40508.
RefSeqNP_387967.1. NC_000964.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2K77NMR-A1-145[»]
2Y1QX-ray1.50A1-150[»]
2Y1RX-ray2.60A/B/C/D/E/F/G/H1-149[»]
3PXGX-ray3.65A/B/C/D/E/F1-485[»]
3PXIX-ray6.93A/B/C1-810[»]
ProteinModelPortalP37571.
SMRP37571. Positions 2-807.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-43708N.
MINTMINT-2838758.
STRING224308.BSU00860.

Proteomic databases

PaxDbP37571.
PRIDEP37571.

Protocols and materials databases

DNASU938481.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB11862; CAB11862; BSU00860.
GeneID938481.
KEGGbsu:BSU00860.
PATRIC18971677. VBIBacSub10457_0087.

Organism-specific databases

GenoListBSU00860. [Micado]

Phylogenomic databases

eggNOGCOG0542.
HOGENOMHOG000218210.
KOK03696.
OMAQTIHYTP.
ProtClustDBCLSK872619.

Enzyme and pathway databases

BioCycBSUB:BSU00860-MONOMER.

Family and domain databases

Gene3D1.10.1780.10. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR013093. ATPase_AAA-2.
IPR003959. ATPase_AAA_core.
IPR018368. Chaperonin_ClpA/B_CS.
IPR001270. Chaprnin_ClpA/B.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR023150. Dbl_Clp-N.
IPR001943. UVR_dom.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
PF02151. UVR. 1 hit.
[Graphical view]
PRINTSPR00300. CLPPROTEASEA.
SMARTSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
PROSITEPS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP37571.

Entry information

Entry nameCLPC_BACSU
AccessionPrimary (citable) accession number: P37571
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents