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Protein

Pur operon repressor

Gene

purR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Controls the transcription of the pur operon for purine biosynthetic genes, binds to the control region of the operon. DNA binding is inhibited by 5-phosphoribosyl 1-pyrophosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBSUB:BSU00470-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pur operon repressor
Gene namesi
Name:purR
Synonyms:yabI
Ordered Locus Names:BSU00470
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Pur operon repressorPRO_0000139699Add
BLAST

Proteomic databases

PaxDbiP37551.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100000235.

Structurei

Secondary structure

1
285
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1713Combined sources
Helixi26 – 327Combined sources
Helixi37 – 5317Combined sources
Beta strandi56 – 627Combined sources
Beta strandi68 – 736Combined sources
Helixi77 – 9115Combined sources
Helixi94 – 963Combined sources
Turni99 – 1013Combined sources
Turni106 – 1105Combined sources
Helixi112 – 12514Combined sources
Turni126 – 1283Combined sources
Beta strandi132 – 1376Combined sources
Turni138 – 1414Combined sources
Helixi142 – 15211Combined sources
Beta strandi156 – 1605Combined sources
Beta strandi170 – 1767Combined sources
Beta strandi182 – 1898Combined sources
Helixi190 – 1923Combined sources
Beta strandi198 – 20912Combined sources
Helixi210 – 2189Combined sources
Helixi220 – 2223Combined sources
Beta strandi225 – 23713Combined sources
Beta strandi247 – 2537Combined sources
Beta strandi257 – 2604Combined sources
Beta strandi263 – 2664Combined sources
Helixi269 – 2724Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1O57X-ray2.20A/B/C/D1-285[»]
1P4AX-ray2.22A/B/C/D1-285[»]
ProteinModelPortaliP37551.
SMRiP37551. Positions 2-273.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37551.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DFT. Bacteria.
COG0503. LUCA.
HOGENOMiHOG000205992.
InParanoidiP37551.
KOiK09685.
OMAiIQTMSLS.
OrthoDBiEOG65BDP5.
PhylomeDBiP37551.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.2020. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR015265. PuR_N.
IPR010078. PurR_Bsub.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
PF09182. PuR_N. 1 hit.
[Graphical view]
ProDomiPD029816. PuR_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01743. purR_Bsub. 1 hit.

Sequencei

Sequence statusi: Complete.

P37551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFRRSGRLV DLTNYLLTHP HELIPLTFFS ERYESAKSSI SEDLTIIKQT
60 70 80 90 100
FEQQGIGTLL TVPGAAGGVK YIPKMKQAEA EEFVQTLGQS LANPERILPG
110 120 130 140 150
GYVYLTDILG KPSVLSKVGK LFASVFAERE IDVVMTVATK GIPLAYAAAS
160 170 180 190 200
YLNVPVVIVR KDNKVTEGST VSINYVSGSS NRIQTMSLAK RSMKTGSNVL
210 220 230 240 250
IIDDFMKAGG TINGMINLLD EFNANVAGIG VLVEAEGVDE RLVDEYMSLL
260 270 280
TLSTINMKEK SIEIQNGNFL RFFKDNLLKN GETES
Length:285
Mass (Da):31,229
Last modified:October 1, 1994 - v1
Checksum:i76B1DB289A3F34FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26185 Genomic DNA. Translation: BAA05282.1.
AL009126 Genomic DNA. Translation: CAB11823.1.
PIRiS66076.
RefSeqiNP_387928.1. NC_000964.3.
WP_003218342.1. NZ_JNCM01000028.1.

Genome annotation databases

EnsemblBacteriaiCAB11823; CAB11823; BSU00470.
GeneIDi23678241.
937000.
KEGGibsu:BSU00470.
PATRICi18971565. VBIBacSub10457_0048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26185 Genomic DNA. Translation: BAA05282.1.
AL009126 Genomic DNA. Translation: CAB11823.1.
PIRiS66076.
RefSeqiNP_387928.1. NC_000964.3.
WP_003218342.1. NZ_JNCM01000028.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1O57X-ray2.20A/B/C/D1-285[»]
1P4AX-ray2.22A/B/C/D1-285[»]
ProteinModelPortaliP37551.
SMRiP37551. Positions 2-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100000235.

Proteomic databases

PaxDbiP37551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB11823; CAB11823; BSU00470.
GeneIDi23678241.
937000.
KEGGibsu:BSU00470.
PATRICi18971565. VBIBacSub10457_0048.

Phylogenomic databases

eggNOGiENOG4105DFT. Bacteria.
COG0503. LUCA.
HOGENOMiHOG000205992.
InParanoidiP37551.
KOiK09685.
OMAiIQTMSLS.
OrthoDBiEOG65BDP5.
PhylomeDBiP37551.

Enzyme and pathway databases

BioCyciBSUB:BSU00470-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP37551.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.2020. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR015265. PuR_N.
IPR010078. PurR_Bsub.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
PF09182. PuR_N. 1 hit.
[Graphical view]
ProDomiPD029816. PuR_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01743. purR_Bsub. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin."
    Ogasawara N., Nakai S., Yoshikawa H.
    DNA Res. 1:1-14(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Identification of the Bacillus subtilis pur operon repressor."
    Weng M., Nagy P.L., Zalkin H.
    Proc. Natl. Acad. Sci. U.S.A. 92:7455-7459(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-25, CHARACTERIZATION.

Entry informationi

Entry nameiPURR_BACSU
AccessioniPrimary (citable) accession number: P37551
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: February 17, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.