P37550 (ISPE_BACSU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 86.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase Short name=CMK EC=2.7.1.148 Alternative name(s): 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase | ||||||
| Gene names |
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| Organism | Bacillus subtilis | ||||||
| Taxonomic identifier | 1423 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 289 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP MF_00061 |
| Catalytic activity | ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00061 |
| Pathway | Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP MF_00061 |
| Sequence similarities | Belongs to the GHMP kinase family. IspE subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Isoprene biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Inferred from electronic annotation. Source: EC ATP bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 289 | 289 | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP MF_00061 | PRO_0000189188 | |||||
Regions | |||||||||
| Nucleotide binding | 94 – 104 | 11 | ATP Potential | ||||||
Sites | |||||||||
| Active site | 10 | 1 | By similarity | ||||||
| Active site | 136 | 1 | By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin." Ogasawara N., Nakai S., Yoshikawa H. DNA Res. 1:1-14(1994) [PubMed: 7584024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.  Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D26185 Genomic DNA. Translation: BAA05281.1. AL009126 Genomic DNA. Translation: CAB11822.1. |
| PIR | S66075. |
| RefSeq | NP_387927.1. NC_000964.3. |
3D structure databases | |
| ProteinModelPortal | P37550. |
| SMR | P37550. Positions 4-278. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBACT00000002258; EBBACP00000002258; EBBACG00000002255. |
| GeneID | 936970. |
| GenomeReviews | Gene locus BSU00460 in contig AL009126_GR. |
| KEGG | bsu:BSU00460. |
| NMPDR | fig|224308.1.peg.46. |
| PATRIC | 18971563. VBIBacSub10457_0047. |
Organism-specific databases | |
| GenoList | BSU00460. [Micado] |
Phylogenomic databases | |
| GeneTree | EBGT00050000000875. |
| HOGENOM | HBG734593. |
| OMA | VSTAEVY. |
| PhylomeDB | P37550. |
| ProtClustDB | PRK00128. |
Enzyme and pathway databases | |
| BioCyc | BSUB:BSU00460-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00061. IspE. [Tree] |
| InterPro | IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR004424. IspE. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view] |
| Gene3D | G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. |
| KO | K00919. |
| PANTHER | PTHR20861:SF2. IspE. 1 hit. |
| Pfam | PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF010376. IspE. 1 hit. |
| SUPFAM | SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. |
| TIGRFAMs | TIGR00154. IspE. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ISPE_BACSU | ||||||||
| Accession | Primary (citable) accession number: P37550 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |