Skip Header

Contribute Send feedback
Read comments (?) or add your own

P37540 (HOLB_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA polymerase III subunit delta'
EC=2.7.7.7
Gene names
Name:holB
Synonyms:yaaS
Ordered Locus Names:BSU00310
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Subunit structure

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.

Ontologies

Keywords
   Biological processDNA replication
   Molecular functionDNA-directed DNA polymerase
Nucleotidyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function3'-5' exonuclease activity

Inferred from electronic annotation. Source: InterPro

DNA-directed DNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329DNA polymerase III subunit delta'
PRO_0000105509

Sequences

Sequence LengthMass (Da)Tools
P37540 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 23F97A1E11FA22E5

FASTA32937,621
        10         20         30         40         50         60 
MAISWKEMNE LQPRVMKLLY NSIEKDRLSH AYLFEGKKGT GKLDAALLLA KSFFCLEGGA 

        70         80         90        100        110        120 
EPCESCRNCK RIESGNHPDL HLVQPDGLSI KKAQIQALQE EFSKTGLESH KKLYIISHAD 

       130        140        150        160        170        180 
QMTANAANSL LKFLEEPNKD TMAVLITEQP QRLLDTIISR CQTLPFQPLQ PKAIEDRLIE 

       190        200        210        220        230        240 
QDVSPHMARL LANMTNNVAE AVELSRNDEF AESRAKVIKL YEVLHQRKGH AFFFIQDQWM 

       250        260        270        280        290        300 
PFFKEKTHQE MGLDMLLLIY RDVLSIQIGN EDKLIYQDLF QSIKQHALQS TQQSVTNQIL 

       310        320 
AVLEAKKRLH SNVNVQGLME HLVLMLQEG

« Hide

References

« Hide 'large scale' references
[1]"Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin."
Ogasawara N., Nakai S., Yoshikawa H.
DNA Res. 1:1-14(1994) [PubMed: 7584024] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D26185 Genomic DNA. Translation: BAA05267.1.
AL009126 Genomic DNA. Translation: CAB11807.1.
PIRS66061.
RefSeqNP_387912.1. NC_000964.3.

3D structure databases

ProteinModelPortalP37540.
SMRP37540. Positions 2-326.
ModBaseSearch...

Protein-protein interaction databases

IntActP37540. 2 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000003203; EBBACP00000003203; EBBACG00000003196.
GeneID935949.
GenomeReviewsGene locus BSU00310 in contig AL009126_GR.
KEGGbsu:BSU00310.
NMPDRfig|224308.1.peg.31.
PATRIC18971533. VBIBacSub10457_0032.

Organism-specific databases

GenoListBSU00310. [Micado]

Phylogenomic databases

GeneTreeEBGT00050000000361.
HOGENOMHBG729459.
OMALMEQLVL.
PhylomeDBP37540.
ProtClustDBPRK08058.

Enzyme and pathway databases

BioCycBSUB:BSU00310-MONOMER.

Family and domain databases

InterProIPR004622. DNA_pol_HolB.
[Graphical view]
KOK02341.
TIGRFAMsTIGR00678. HolB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHOLB_BACSU
AccessionPrimary (citable) accession number: P37540
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents