Reviewed,
UniProtKB/Swiss-Prot P37537 (KTHY_BACSU)
Last modified
November 24, 2009.
Version 66.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Thymidylate kinase EC=2.7.4.9 Alternative name(s): dTMP kinase | ||||||
| Gene names |
| ||||||
| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1423 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 212 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. Ref.4 |
| Catalytic activity | ATP + dTMP = ADP + dTDP. HAMAP MF_00165 |
| Sequence similarities | Belongs to the thymidylate kinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP thymidylate kinase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin." Ogasawara N., Nakai S., Yoshikawa H. DNA Res. 1:1-14(1994) [PubMed: 7584024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [3] | "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later." Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A. Microbiology 155:1758-1775(2009) [PubMed: 19383706] [Abstract] Cited for: SEQUENCE REVISION TO 101. |
| [4] | Gilles A.M., Barzu O. Unpublished observations (JUN-1996) Cited for: FUNCTION. |
Cross-references
Sequence databases | |
|---|---|
| D26185 Genomic DNA. Translation: BAA05264.1. AL009126 Genomic DNA. Translation: CAB11804.2. | |
| PIR | S66058. |
| RefSeq | NP_387909.2. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 937018. |
| GenomeReviews | Gene locus BSU00280 in contig AL009126_GR. |
| KEGG | bsu:BSU00280. |
| NMPDR | fig|224308.1.peg.28. |
Organism-specific databases | |
| SubtiList | BG10092. tmk. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P37537. |
Enzyme and pathway databases | |
| BRENDA | 2.7.4.9. 150. |
Family and domain databases | |
| HAMAP | MF_00165. [Tree] |
| InterPro | IPR018094. Thymidylate_kin. IPR000062. Thymidylate_kin-like. IPR018095. Thymidylate_kin_CS. [Graphical view] |
| PANTHER | PTHR10344. Thymidylate_kin. 1 hit. |
| Pfam | PF02223. Thymidylate_kin. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00041. DTMP_kinase. 1 hit. |
| PROSITE | PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KTHY_BACSU | ||||||||
| Accession | Primary (citable) accession number: P37537 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| SIMILARITY comments Index of protein domains and families |

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