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P37537 (KTHY_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate kinase
EC=2.7.4.9
Alternative name(s):
dTMP kinase
Gene names
Name:tmk
Synonyms:yaaP
Ordered Locus Names:BSU00280
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. Ref.4

Catalytic activity

ATP + dTMP = ADP + dTDP. HAMAP MF_00165

Sequence similarities

Belongs to the thymidylate kinase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processdTDP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidylate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Thymidylate kinase HAMAP MF_00165
PRO_0000155238

Regions

Nucleotide binding10 – 178ATP Potential

Experimental info

Sequence conflict1011S → P in BAA05264. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P37537 [UniParc].

Last modified June 16, 2009. Version 2.
Checksum: 9763C20FA7F1DE85

FASTA21223,866
        10         20         30         40         50         60 
MSGLFITFEG PEGAGKTTVL QEIKNILTAE GLQVMATREP GGIDIAEQIR EVILNENNIL 

        70         80         90        100        110        120 
MDPKTEALLY AAARRQHLVE KVKPALEQGF IVLCDRFIDS SLAYQGYARG LGIDEVLSIN 

       130        140        150        160        170        180 
EFAIGDMMPH VTVYFSIDPE EGLKRIYANG SREKNRLDLE KLDFHTKVQE GYQELMKRFP 

       190        200        210 
ERFHSVDAGQ SKDLVVQDVL KVIDEALKKI QL

« Hide

References

« Hide 'large scale' references
[1]"Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin."
Ogasawara N., Nakai S., Yoshikawa H.
DNA Res. 1:1-14(1994) [PubMed: 7584024] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
Microbiology 155:1758-1775(2009) [PubMed: 19383706] [Abstract]
Cited for: SEQUENCE REVISION TO 101.
[4]Gilles A.M., Barzu O.
Unpublished observations (JUN-1996)
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D26185 Genomic DNA. Translation: BAA05264.1.
AL009126 Genomic DNA. Translation: CAB11804.2.
PIRS66058.
RefSeqNP_387909.2. NC_000964.3.

3D structure databases

ProteinModelPortalP37537.
SMRP37537. Positions 4-208.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000000367; EBBACP00000000367; EBBACG00000000365.
GeneID937018.
GenomeReviewsGene locus BSU00280 in contig AL009126_GR.
KEGGbsu:BSU00280.
NMPDRfig|224308.1.peg.28.
PATRIC18971527. VBIBacSub10457_0029.

Organism-specific databases

GenoListBSU00280. [Micado]

Phylogenomic databases

GeneTreeEBGT00050000002345.
HOGENOMHBG626009.
PhylomeDBP37537.
ProtClustDBPRK00698.

Enzyme and pathway databases

BioCycBSUB:BSU00280-MONOMER.

Family and domain databases

HAMAPMF_00165. Thymidylate_kinase.
[Tree]
InterProIPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
KOK00943.
PANTHERPTHR10344. Thymidylate_kin. 1 hit.
PfamPF02223. Thymidylate_kin. 1 hit.
[Graphical view]
TIGRFAMsTIGR00041. DTMP_kinase. 1 hit.
PROSITEPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKTHY_BACSU
AccessionPrimary (citable) accession number: P37537
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: June 16, 2009
Last modified: January 25, 2012
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

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