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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi410Magnesium 1By similarity1
Metal bindingi417Magnesium 1By similarity1
Metal bindingi417Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU00820-MONOMER
SABIO-RKP37477

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase
Short name:
LysRS
Gene namesi
Name:lysS
Ordered Locus Names:BSU00820
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001526001 – 499Lysine--tRNA ligaseAdd BLAST499

Proteomic databases

PaxDbiP37477
PRIDEiP37477

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP37477, 1 interactor
MINTiP37477
STRINGi224308.Bsubs1_010100000415

Structurei

3D structure databases

ProteinModelPortaliP37477
SMRiP37477
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CRK Bacteria
COG1190 LUCA
HOGENOMiHOG000236578
InParanoidiP37477
KOiK04567
OMAiMMNIIPG
PhylomeDBiP37477

Family and domain databases

CDDicd00775 LysRS_core, 1 hit
HAMAPiMF_00252 Lys_tRNA_synth_class2, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR002313 Lys-tRNA-ligase_II
IPR034762 Lys-tRNA-ligase_II_bac/euk
IPR018149 Lys-tRNA-synth_II_C
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PIRSFiPIRSF039101 LysRS2, 1 hit
PRINTSiPR00982 TRNASYNTHLYS
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00499 lysS_bact, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

P37477-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQEEHNHEE LNDQLQVRRD KMNQLRDNGI DPFGARFERT HQSQEVISAY
60 70 80 90 100
QDLTKEELEE KAIEVTIAGR MMTKRGKGKA GFAHLQDLEG QIQIYVRKDS
110 120 130 140 150
VGDDQYEIFK SSDLGDLIGV TGKVFKTNVG ELSVKATSFE LLTKALRPLP
160 170 180 190 200
DKYHGLKDVE QRYRQRYLDL IVNPDSKHTF ITRSKIIQAM RRYLDDHGYL
210 220 230 240 250
EVETPTMHSI PGGASARPFI THHNALDIPL YMRIAIELHL KRLIVGGLEK
260 270 280 290 300
VYEIGRVFRN EGVSTRHNPE FTMIELYEAY ADYKDIMSLT ENLVAHIAQE
310 320 330 340 350
VLGTTTIQYG EEQIDLKPEW KRIHMVDAVK EATGVDFWEE VTVEQAREYA
360 370 380 390 400
KEHEVEIKDS MTVGHIINEF FEQKIEETLI QPTFIYGHPV EISPLAKKNP
410 420 430 440 450
EDPRFTDRFE LFIVGREHAN AFTELNDPID QRERFEAQLK EREAGNDEAH
460 470 480 490
LMDEDFVEAL EYGMPPTGGL GIGIDRLVML LTNAPSIRDV LLFPQMRQR
Length:499
Mass (Da):57,539
Last modified:October 1, 1994 - v1
Checksum:i9D082E784473EFE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26185 Genomic DNA Translation: BAA05316.1
AL009126 Genomic DNA Translation: CAB11858.1
PIRiS66111
RefSeqiNP_387963.1, NC_000964.3
WP_003242743.1, NZ_JNCM01000028.1

Genome annotation databases

EnsemblBacteriaiCAB11858; CAB11858; BSU00820
GeneIDi936911
KEGGibsu:BSU00820
PATRICifig|224308.179.peg.82

Similar proteinsi

Entry informationi

Entry nameiSYK_BACSU
AccessioniPrimary (citable) accession number: P37477
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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