Reviewed, UniProtKB/Swiss-Prot P37476 (FTSH_BACSU)

Names and origin

Protein names

Recommended name:
    Cell division protease ftsH homolog
    EC=3.4.24.-

Gene names

Name:	ftsH
Ordered Locus Names:	BSU00690

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	637 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Seems to act as an ATP-dependent zinc metallopeptidase By similarity.
Cofactor	Binds 1 zinc ion per subunit Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	In the N-terminal section; belongs to the AAA ATPase family. In the C-terminal section; belongs to the peptidase M41 family.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 637	637	Cell division protease ftsH homolog		PRO_0000084627
Regions
	Topological domain	1 – 7	7	Cytoplasmic Potential
	Transmembrane	8 – 28	21	Potential
	Topological domain	29 – 109	81	Extracellular Potential
	Transmembrane	110 – 130	21	Potential
	Topological domain	131 – 637	507	Cytoplasmic Potential
	Nucleotide binding	201 – 208	8	ATP Potential
Sites
	Active site	424	1	By similarity
	Metal binding	423	1	Zinc; catalytic By similarity
	Metal binding	427	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P37476-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: C62B6C518B91C9D3	FASTA	637	70,937
	10 20 30 40 50 60 MNRVFRNTIF YLLILLVVIG VVSYFQTSNP KTENMSYSTF IKNLDDGKVD SVSVQPVRGV 70 80 90 100 110 120 YEVKGQLKNY DKDQYFLTHV PEGKGADQIF NALKKTDVKV EPAQETSGWV TFLTTIIPFV 130 140 150 160 170 180 IIFILFFFLL NQAQGGGSRV MNFGKSKAKL YTEEKKRVKF KDVAGADEEK QELVEVVEFL 190 200 210 220 230 240 KDPRKFAELG ARIPKGVLLV GPPGTGKTLL AKACAGEAGV PFFSISGSDF VEMFVGVGAS 250 260 270 280 290 300 RVRDLFENAK KNAPCLIFID EIDAVGRQRG AGLGGGHDER EQTLNQLLVE MDGFSANEGI 310 320 330 340 350 360 IIIAATNRAD ILDPALLRPG RFDRQITVDR PDVIGREAVL KVHARNKPLD ETVNLKSIAM 370 380 390 400 410 420 RTPGFSGADL ENLLNEAALV AARQNKKKID ARDIDEATDR VIAGPAKKSR VISKKERNIV 430 440 450 460 470 480 AYHEGGHTVI GLVLDEADMV HKVTIVPRGQ AGGYAVMLPR EDRYFQTKPE LLDKIVGLLG 490 500 510 520 530 540 GRVAEEIIFG EVSTGAHNDF QRATNIARRM VTEFGMSEKL GPLQFGQSQG GQVFLGRDFN 550 560 570 580 590 600 NEQNYSDQIA YEIDQEIQRI IKECYERAKQ ILTENRDKLE LIAQTLLKVE TLDAEQIKHL 610 620 630 IDHGTLPERN FSDDEKNDDV KVNILTKTEE KKDDTKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin." Ogasawara N., Nakai S., Yoshikawa H. DNA Res. 1:1-14(1994) [PubMed: 7584024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D26185 Genomic DNA. Translation: BAA05304.1. AL009126 Genomic DNA. Translation: CAB11845.1.
PIR	E69627.
RefSeq	NP_387950.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M41.009.
Genome annotation databases
GeneID	938094.
GenomeReviews	Gene locus BSU00690 in contig AL009126_GR.
KEGG	bsu:BSU00690.
NMPDR	fig|224308.1.peg.69.
Organism-specific databases
SubtiList	BG10132. ftsH. [Micado]
CMR	Search...
Phylogenomic databases
HOGENOM	P37476.
OMA	NLRENAD
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. IPR005936. Pept_M41_FtsH. IPR011546. Pept_M41_FtsH_extracell. IPR000642. Peptidase_M41. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF06480. FtsH_ext. 1 hit. PF01434. Peptidase_M41. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01241. FtsH_fam. 1 hit.
PROSITE	PS00674. AAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTSH_BACSU

Accession

Primary (citable) accession number: P37476

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	November 24, 2009
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)